112023 Results for: "THI+Total+Healthcare+Innovation+GmbH&pageNo=10&view=list"

Supplier: Abnova

Recombinant protein, polq( np_006587, 2572 a.a. - 2680 a.a.) partial recombinant protein with gst tag. 1 * 2 µG

Supplier: Abnova

Recombinant protein, sgpp2( np_689599.2, 1 a.a. - 399 a.a.) full-length recombinant protein with gst tag. 1 * 2 µG

Supplier: Abnova

Recombinant protein, leo1( np_620147.1, 1 a.a. - 666 a.a.) full-length recombinant protein with gst tag. 1 * 2 µG

Supplier: Abnova

Recombinant protein, gzmk( np_002095.1, 1 a.a. - 264 a.a.) full-length recombinant protein with gst tag. 1 * 2 µG

Supplier: STEMCELL Technologies

Interleukin 1 beta (IL-1β) is synthesised as an inactive precursor protein or pro-IL-1β. This precursor is cleaved intracellularly by caspase 1 (IL-1β convertase) to form the active form of the protein that is later secreted (Allan et al.). IL-1β binds to IL-1 receptor and activates intracellular signaling via the MAPK or NF-kB pathway. IL-1β is released by monocytes, tissue macrophages, and dendritic cells in response to infection or injury and induces expression of acute-phase proteins. It also promotes the infiltration of inflammatory and immunocompetent cells from the circulation into the extravascular space and affected tissues, by stimulating the expression of adhesion molecules on endothelial cells. IL-1β also affects other immune cells; for example, it co-stimulates T cell functions together with antigen or mitogen. It also stimulates Th17 differentiation and B cell proliferation in an IL-6-dependent manner. Mice deficient in IL-1β do not show phenotypical differences from wild-type mice; however, they have a reduced response to inflammation, suggesting that IL-1β plays a key role in inflammatory diseases (Dinarello).

Supplier: STEMCELL Technologies

Interleukin 15 (IL-15) is a four-alpha helix bundle cytokine with many similar properties to IL-2. The IL-15 receptor is a heterotrimeric receptor composed of IL-15Ra (the high-affinity receptor for IL-15), as well as IL-2/15Rb (CD122) and common gamma chain (CD132). IL-15 binds to IL-15Rα receptor and can then be presented in trans to IL-2/15Rb and common gamma chain on other cells. Trans-presentation is thought to be the major mechanism by which IL-15-mediated responses occur in mice, although may not be necessary in humans (Castillo et al.). The cytoplasmic domains of IL-2/15Rb and common gamma chain mediate signaling to activate JAK/STAT and PI3K pathways. IL-15 supports the survival and proliferation of naïve CD4+ and CD8+ T cells, and promotes homeostasis of memory T cells. IL-15 also promotes the survival and differentiation of NK cells and regulates their cytolytic activity (Ma et al.). This product is animal component-free.

Supplier: VARIAN

TUBING SS REG 10MX1/16INCHX0.25 EA=10MR 1 * 1 items

Supplier: Abnova

Recombinant protein, cpa3( np_001861.1, 1 a.a. - 417 a.a.) full-length recombinant protein with gst tag. 1 * 2 µG

Supplier: Abnova

Recombinant protein, fgf2( np_001997, 189 a.a. - 288 a.a.) partial recombinant protein with gst tag. 1 * 2 µG

Supplier: TRESTON

Hook R1, L50 /15kg (5pcs),L50 /15kg (5pcs) 1 * 1 items

Supplier: Lovibond Tintometer

Lamp 12V 10W, spare for Lovibond Model F (Tintometer 12 41 02) 1 * 2 items

Supplier: MACHEREY-NAGEL

COLUMN 100 10µM NH2 250X4MM NUCLEOSIL 1 * 1 KIT

Supplier: Corning

TIP MLA-STYLE 10ML 1 * 100 items

Supplier: Merck

KREBS-RINGER BICARBONATE BUFFER, WITH 1800 MG/L GLUCOSE, WITHOUT CALCIUM CHLORIDE AND SODIUM BICARBONATE. CELL CULTURE 1 * 1 Each

Supplier: Thermo Fisher Scientific

TANK CYLIND.COVER LIGHTWEIGHT LLDPE 38 L 1 * 1 items

Supplier: Abnova

Recombinant protein, kir2dl3( np_056952.2, 1 a.a. - 341 a.a.) full-length recombinant protein with gst tag. 1 * 2 µG

Supplier: Abnova

Recombinant protein, nmnat1( np_073624.2, 1 a.a. - 279 a.a.) full-length recombinant protein with gst tag. 1 * 2 µG

Supplier: Abnova

Recombinant protein, dpp10( aah30832.1, 1 a.a. - 796 a.a.) full-length recombinant protein with gst tag. 1 * 2 µG

Supplier: Abnova

Recombinant protein, traf7( aah24267.1, 1 a.a. - 594 a.a.) full-length recombinant protein with gst tag. 1 * 2 µG

Supplier: Abnova

Recombinant protein, lefty2( np_003231.2, 1 a.a. - 366 a.a.) full-length recombinant protein with gst tag. 1 * 2 µG

Supplier: Abnova

Recombinant protein, wnt3( np_110380.1, 1 a.a. - 355 a.a.) full-length recombinant protein with gst tag. 1 * 2 µG

Supplier: Abnova

Recombinant protein, cd3e( aah49847.1, 23 a.a. - 208 a.a.) full-length recombinant protein with gst tag. 1 * 2 µG

Supplier: Abnova

Recombinant protein, slc14a1( aah50539.1, 1 a.a. - 389 a.a.) full-length recombinant protein with gst tag. 1 * 2 µG

Supplier: Abnova

Recombinant protein, golga2( -, 1 a.a. - 346 a.a.) full-length recombinant protein with gst tag. 1 * 2 µG

Supplier: Abnova

Recombinant protein, rhobtb1( np_055651.1, 1 a.a. - 696 a.a.) full-length recombinant protein with gst tag. 1 * 2 µG

Supplier: OHAUS

Intuitive balances designed for routine weighing. Striking the ideal balance between inventive features and functional, uncomplicated weighing capabilities, the OHAUS Adventurer incorporates all of the applications necessary for routine weighing and measurement activities. With a colour touchscreen, three level user management to fulfill GLP/GMP compliance capabilities, two USB ports, and much more, Adventurer is the most complete balance in its class.

Supplier: Brand

PP. These 0,2 and 0,5 ml PCR tubes with attached caps are compatible with leading thermal cyclers with heated lids.

Supplier: STEMCELL Technologies

Leukemia inhibitory factor (LIF) is an interleukin 6 class cytokine that regulates a broad variety of developmental functions. After LIF binds to LIF receptor (LIFR), LIFR associates with gp130 and activates JAK/STAT and MAPK signaling (Auernhammer and Melmed; Suman et al.). LIFR activation of STAT3 is essential for maintaining the mouse embryonic stem cell phenotype (Niwa et al.). Produced by the endometrium, LIF plays an important autocrine and paracrine role in implantation by regulating proliferation, invasion, and differentiation of trophoblasts following blastocyst attachment (Auernhammer and Melmed; Suman et al.). Human LIF can be used for the maintenance of mouse embryonic stem cells, however mouse LIF cannot bind to the human receptor, thus rendering mouse LIF inactive (Dahéron et al.). LIF is produced by CD4+ and activated regulatory T cells, and promotes Foxp3 expression, while repressing Th17 lineage-specific genes (Metcalfe). LIF is also secreted by mesenchymal stromal cells, where it supports hematopoiesis and immune modulation (Nasef et al.).

Supplier: STEMCELL Technologies

Interleukin 21 (IL-21) is a pleiotropic cytokine that is composed of four α-helical bundles and primarily produced by natural killer T (NKT) cells, T follicular helper (Tfh) cells, and Th17 cells (Spolski and Leonard 2008). IL-21 signals via heterodimers of the IL-21 receptor (IL-21R) and the IL2RG-encoded common cytokine receptor γ-chain (Parrish-Novak et al.; Ozaki K et al. 2000), and utilizes the JAK/STAT, MAPK, and PI3K pathways (Spolski and Leonard 2014). IL-21 has been shown to have a critical role in regulating immunoglobulin production and differentiation of the pro-inflammatory Th17 population of cells (Ozaki et al. 2002; Nurieva et al.). Additionally, IL-21 specifically sustains CD8+ T cell effector activity and provides a mechanism of CD4+ T cell help during chronic viral infection (Elsaesser et al.). IL-21 signaling was also found critical for the development of type 1 diabetes in NOD mice (Sutherland et al.) and control of T cell autoimmunity by regulatory B cells (Yoshizaki et al.). This product is animal component-free.

Supplier: STEMCELL Technologies

Interleukin 21 (IL-21) is a pleiotropic cytokine that is composed of four α-helical bundles and primarily produced by natural killer T (NKT) cells, T follicular helper (Tfh) cells, and Th17 cells (Spolski and Leonard 2008). IL-21 signals via heterodimers of the IL-21 receptor (IL-21R) and the IL2RG encoded common cytokine receptor γ-chain (Parrish-Novak et al.; Ozaki K et al. 2000), and utilizes the JAK/STAT, MAPK, and PI3K pathways (Spolski and Leonard 2014). IL-21 has been shown to have a critical role in regulating immunoglobulin production and differentiation of the pro-inflammatory Th17 population of cells (Ozaki et al. 2002; Nurieva et al.). Additionally, IL-21 specifically sustains CD8+ T cell effector activity and provides a mechanism of CD4+ T cell help during chronic viral infection (Elsaesser et al.). IL-21 signaling was also found critical for the development of type 1 diabetes in NOD mice (Sutherland et al.) and control of T cell autoimmunity by regulatory B cells (Yoshizaki et al.).