"Stemcell Technologies"

Supplier: Stemcell Technologies

Human (Actin) peptide pool is a lyophilised mixture of 92 peptides from human actin, alpha skeletal muscle, and consists of 15-mer peptides with 11-amino-acid overlaps that cover amino acids 1 to 377 on actin. It is frequently used as a negative control. Actin, alpha skeletal muscle, is part of the highly conserved actin protein family and is the predominant isoform found in adult skeletal muscle (Laing et al.). Peptide pools are useful for a broad range of applications, including vaccine development, immunological research, and diagnostic assay development.

Supplier: Stemcell Technologies

Thrombopoietin (TPO) is a key regulator of megakaryocytopoiesis and thrombopoiesis in vitro and in vivo. TPO stimulates the proliferation and maturation of megakaryocytes and has an important role in regulating the level of circulating platelets in vivo. TPO also promotes the survival, self-renewal, and expansion of hematopoietic stem cells and primitive multilineage progenitor cells. It is commonly used with other cytokines such as stem cell factor (SCF) and Flt3/Flk-2 Ligand to promote expansion of primitive hematopoietic cells in culture (Hitchcock andamp; Kaushansky). The TPO receptor, c-Mpl, is expressed at all stages of megakaryopoiesis, from hematopoietic stem and progenitor cells to mature platelets.

Supplier: Stemcell Technologies

Substrate for ELISA antibody pair kits.

Supplier: Stemcell Technologies

Human amyloid-β (1 to 42) peptide is a neurotoxic peptide fragment that can oligomerize to form amyloid plaques, thus contributing to the onset of Alzheimer's disease (Paradis et al.; Teplow; Wolfe). These neurotoxic peptide fragments also modulate the expression of Bcl-2 and Bax in human neurons (Paradis et al.).

Supplier: Stemcell Technologies

Immunomagnetic negative selection kit

Supplier: Stemcell Technologies

Rat monoclonal antibody against mouse CD3, PerCP-Cy5.5-conjugated.

Supplier: Stemcell Technologies

Myostatin is a member of transforming growth factor beta (TGF-β) superfamily that signals by binding to activin type II receptor, resulting in the recruitment of either ALK3 or ALK4 coreceptor, and activation of SMAD2/3 (Kondás et al.). It is released by myocytes and inhibits muscle growth and ability to regenerate (Lee and Lee). Myostatin appears to affect the lipid catabolic metabolism of adipocytes and inhibits preadipocyte differentiation, as demonstrated in the 3T3-L1 cell line (Li et al.).

Supplier: Stemcell Technologies

Stimulating T cells with CMV (HLA Class I Control) Peptide pool releases downstream cytokines and upregulates activation markers, enabling antigen-specific T cells to be detected or isolated for analysis. CMV Peptide pool is a lyophilised mixture of 14 peptides from the human cytomegalovirus (CMV) and consists of defined HLA class I-restricted T cell epitopes. Viral peptide pools are useful for a broad range of applications, including vaccine development, immunological research, and diagnostic assay development. For consistency and reproducibility across your applications, CMV Peptide pools from STEMCELL are formulated as lyophilised trifluoroacetate salts, with a purity ≥95%.

Supplier: Stemcell Technologies

The platelet-derived growth factor (PDGF) family has five heparin-binding members that assemble into four homodimers (PDGF-AA, PDGF-BB, PDGF-CC, and PDGF-DD) and one heterodimer (PDGF-AB; Fretto et al.; Li and Eriksson). PDGF signals through the receptor tyrosine kinases PDGFRα and PDGFRβ. It has been shown that PDGF-induced migration involves signaling pathways involving MEK/ERK, EGFR, Src, and PI3K/AKT (Kim et al.). PDGF is a potent mitogen for cells of mesenchymal origin, such as fibroblasts, glial cells, and vascular smooth muscle cells. PDGF has been implicated in pathogenesis of atherosclerosis, glomerulonephritis, cancer, and in the contraction of vascular smooth muscle cells of rat aortic tissues (Fretto et al.; Sachinidis et al.). PDGF-BB is secreted by osteoblasts to induce mesenchymal stem cell migration and angiogenesis. It has also been shown that PDGF-BB is secreted by preosteoclasts during bone modeling and remodeling to induce angiogenesis and thus proper osteogenesis (Xie et al.).

Supplier: Stemcell Technologies

For expansion and differentiation of human CD34+ hematopoietic progenitor cells to NK cells.

Supplier: Stemcell Technologies

Immunomagnetic isolation of untouched mouse naive CD4+ T cells

Supplier: Stemcell Technologies

Immunomagnetic positive selection of mouse CD45+ TILs from single-cell suspensions of solid tumors.

Supplier: Stemcell Technologies

Rat monoclonal IgG2a antibody against human, mouse, rhesus CD49f, Pacific Blue™-conjugated.

Supplier: Stemcell Technologies

Mouse monoclonal IgG2b antibody against human OCT4 (OCT3), unconjugated.

Supplier: Stemcell Technologies

Immunomagnetic positive selection of particle-free mouse cells labelled with PE-conjugated antibodies.

Supplier: Stemcell Technologies

Rat (WI) monoclonal IgG2b antibody against mouse TER119.