112279 Results for: "Scrubber+Systems&pageNo=10&view=list"

Supplier: OMNIFIT

EZ PACKING SLEEVE 10MM 1 * 1 items

Supplier: Thermo Fisher Scientific

TIP EJECTOR-PART 1 1 * 1 items

Supplier: Merck

CYCLOHEXIMIDE SOLUTION 10X10ML 1 * 100 mL

Supplier: Ambion

dNTPs for cDNA Probe Synthesis 1 * 300 µl

Supplier: Socorex Isba

BARREL ASSEMBLY 10µL 1 * 1 items

Supplier: GERHARDT

ISOVERSINIC TUBING 12/17 ISO 1 * 1 m

Supplier: HIRSCHMANN

Flask volumetric, capacity 20ml, glass stopper, class A, NS 12/21, amber graduation, conformity certified. 1 * 2 items

Supplier: DIAGNOSTIC SYSTEMS DIASYS

Test kit Alkalische phosphatase dgkc 10x20+2x30ml 1 * 1 KIT

Supplier: Thermo Fisher Scientific

O-RING 2,6 X 1,3 EPDM 1 * 1 items

Supplier: MACHEREY-NAGEL

NucleoBond Xtra EF Buffer Set I buffer set for the isolation of endotoxin-free low-copy plasmids, BACs, PACs, and P1 constructs, onl y applicable with NucleoBond Xtra EF kits, sufficient for 12 Xtra Maxi preps or 18 Xtra Midi preps - Buffer RES-EF, B 1 * 1 SET

Supplier: MACHEREY-NAGEL

NucleoBond Xtra Buffer Set I buffer set for the isolation of low-copy plasmids, BACs, PACs, and P1 constructs, only applicable with NucleoBond Xtra kits, sufficient for 12 Xtra Maxi preps or 18 Xtra Midi preps - Buffer RES, Buffer LYS, Buffer NEU, RN 1 * 1 SET

Supplier: CONTACTO

matt gebürstet, einseitig graduiert mit 1-l Skalierung, gebördelter Rand, Bodenreifen mit Ablauflöchern für Spülwasser, extra schwere Qualität 1 * 1 ST

Supplier: Merck

CITRATE-PHOSPHATE-DEXTROSE SOLUTIONASEPT ICALLY FIL 1 * 1 Each

Supplier: STEMCELL Technologies

Interleukin 2 (IL-2) is a monomeric cytokine that was originally identified as a T cell growth factor (Gaffen and Liu). It binds to heterotrimeric receptors consisting of CD25, CD122, and CD132. Upon binding, it activates JAK3-, STAT5-, and AKT-dependent signaling pathways, which results in cellular proliferation and survival (Ma et al.). The majority of IL-2 is secreted by activated CD4+ and CD8+ T cells, although B cells and dendritic cells were found to produce IL-2 in small amounts. IL-2 downregulates immune responses to prevent autoimmunity during thymic development, influences the development of CD4+CD25+ regulatory T cells, and affects development of follicular helper T cells. IL-2 also controls inflammation by inhibiting Th17 differentiation (Banchereau et al.). High IL-2 levels in serum are associated with progression of scleroderma, rheumatoid arthritis, and gastric and non-small cell lung cancer, though no known disease can be directly attributed to the lack or excess of IL-2 (Gaffen and Liu).

Supplier: STEMCELL Technologies

Interleukin 6 (IL-6) is a pleiotropic growth factor with a wide range of biological activities in immune regulation, hematopoiesis, and oncogenesis. IL-6 is produced by a variety of cell types including T cells, B cells, monocytes and macrophages, fibroblasts, hepatocytes, vascular endothelial cells, and various tumor cell lines. On its own or in combination with other factors such as IL-2 and interferon-γ, IL-6 stimulates the proliferation of B cells, T cells, and hybridoma cells (Nordan et al.; Van Snick et al.; Gauldie et al.; Mihara et al.; Tanaka et al). In combination with cytokines such as IL-3, GM-CSF, and SCF, IL-6 has been shown to promote hematopoietic progenitor cell proliferation and differentiation in vitro. IL-6 signals through a cell surface type I cytokine receptor complex consisting of the ligand-binding IL-6α (CD126) and the signal-transducing gp130 subunits. The binding of IL-6 to its receptor system includes activation of the JAK/STAT signaling pathway (Mihara et al.; Peters et al; Tanaka et al.).

Supplier: ELGA LabWater

Consumables Pack for Micra 10µm Depth Filter, 5µm Carbon Filter, Purification Cartridge 1 * 1 items

Supplier: Abnova

Recombinant protein, epcam (np_002345.1) recombinant protein without tag. 1 * 2 µG

Supplier: Abnova

Recombinant protein, il2rb (np_000869.1) recombinant protein without tag. 1 * 2 µG

Supplier: ProSci Inc.

BAFF is mainly produced by innate immune cells such as neutrophils, monocytes, macrophages, dendritic cells, follicular dendritic cells. T cells, activated B cells, some malignant B cells and also non-lymphoid cells like astrocytes, synoviocytes and epithelial cells can also produce BAFF. BAFF binds three distinct receptors (BAFF-R, TACI and BCMA) expressed predominantly on B cells, although activated T cells also express BAFF-R. BAFF is a master regulator of peripheral B cell survival, and together with IL-6, promotes Ig class-switching and plasma cell differentiation. Besides its major role in B cell biology, BAFF co-stimulates activated T cells. Deregulated expression of BAFF leads to autoimmune disorders in mice. In humans, elevated levels of soluble BAFF have been detected in the serum of patients with various autoimmune diseases such as Sjoegren syndrome, Rheumatoid arthritis (RA), Multiple sclerosis (MS) and Systemic Lupus Erythematosus (SLE). BAFF has also increased levels in some lymphoid cancers. Processed human BAFF can either remain as a trimer, which is usual for TNF family ligands or assemble into 60-mer composed of 20 trimers. Mouse BAFF 60-mer has been identified in the serum of BAFF transgenic mice. Oligomerisation of BAFF 3-mer into 60-mer in human BAFF is prevented by mutation of His218, a residue critical for 3-mer-to-3-mer interactions, but not for receptor binding. Despite the predominant functional role of processed BAFF in vivo, membrane-bound BAFF might also play a role. Indeed, soluble BAFF (3-mer) can trigger BAFF-R but not TACI or BCMA, whereas oligomeric forms of BAFF (BAFF 60-mer), which mimic membrane-bound BAFF, activate all BAFF receptors.

Supplier: STEMCELL Technologies

Receptor activator of nuclear factor kappa-B ligand (RANKL) is a member of the tumor necrosis factor (TNF) superfamily (Anderson et al.). Cytokines in the TNF superfamily are involved in a variety of long-term cellular activities such as differentiation, proliferation, and cell death (MacEwan). RANKL is a type II homotrimeric transmembrane protein expressed in both a membrane-bound and secreted form (Ikeda et al.). RANKL binds to the receptor activator of nuclear factor kappa-B (RANK). Upon binding to its receptor, RANKL activates the AKT signaling pathway (Moon et al.). Osteoprotegerin (OPG) may also bind RANKL, and this binding competes with RANKL-RANK binding (Lacey et al.). RANKL is involved in osteoclastogenesis (Lacey et al.; Yasuda et al.) and T cell activation (Wong et al.).

Supplier: STEMCELL Technologies

Betacellulin is a member of the epidermal growth factor (EGF) family, and signals through EGF receptor and ERBB4. It activates ERK and AKT pathways, which induces neural stem cell proliferation and prevents spontaneous differentiation in culture. Betacellulin stimulates the expansion of neural stem cells, transit-amplifying cells, and neuroblasts derived from subventricular zone and dentate gyrus (Gómez-Gaviro et al.). It is a potent mitogen for retinal pigment epithelial cells and vascular smooth muscle cells. Betacellulin down-regulates E-cadherin expression in ovarian cancer cell lines via MEK/ERK1/2 and PI3K/AKT signaling pathways, thus increasing cell migration (Zhao et al.). It is a modulator of interferon (IFN) response and enhances anti-viral effects of IFN (Al-Yahya et al.). Betacellulin is expressed in pancreatic α cells, β cells, and duct cells. It induces the proliferation of pancreatic cancer cell lines, inhibits apoptosis, promotes the neogenesis of β cells, and converts non-β cells into insulin-producing cells (Kawaguchi et al.; Miyagawa al.; Saito et al.).

Supplier: STEMCELL Technologies

Interleukin 9 (IL-9) has pleiotropic functions in the immune system and signals through its specific IL-9 receptor (IL-9R) (Renauld et al.). IL-9/IL-9R signaling pathway mainly targets the downstream activation of JAK/STAT (janus kinase/signal transducer and activator of transcription) and subsequent phosphorylation cascades initiated by multiple kinases including IRS–PI3K–PKB (insulin receptor substrate, phosphatidyl-inositol 3-kinases, protein kinase-B) and ERK (Knoops and Renauld; Fontaine et al.). IL-9 has been shown to have a role in Th1/Th17-mediated inflammation and in regulatory T cell responses (Singh et al.; Goswami and Kaplan). IL-9/IL-9R signaling pathway represents a novel endogenous anti-apoptotic mechanism for cortical neurons (Fontaine et al.). IL-9 secreting T cells, termed Th9 cells, contribute to both effective immunity and immunopathological disease, and have been shown to have a role in the treatment of allergic and autoimmune disease (Kaplan et al.).

Supplier: Abnova

Recombinant protein, htr1a (np_000515.2) recombinant protein without tag. 1 * 2 µG

Supplier: Abnova

Recombinant protein, il2ra (aai56628.1) recombinant protein without tag. 1 * 2 µG

Supplier: Hielscher Ultrasonics

Sonotrode aus Titan, Ø7mm, Länge ca. 80mm, für Probenmengen von 10ml bis 2 1 * 1 ST

Supplier: GERING

HYDROMETER BAUME 1-3 0,1 15C 1 * 1 items

Supplier: Abnova

Recombinant protein, ccr10 (aah98132.1) recombinant protein without tag. 1 * 2 µG

Supplier: Ahlstrom-Munksjö

IN.PAPER PH 1-14 ROLLE 1 * 1 items

Supplier: MORGAN ADVANCED MATERIALS HALD

PLATE FIRM 200X10X200MM 1 * 1 items

Supplier: Socorex Isba

SOC NOZZLE EXTENSION 10ÁL 1 * 1 items