112293 Results for: "Sampler+Racks&pageNo=10&view=list"

Supplier: MP Biomedicals

PLURONIC F-68® POLYOL 1 * 100 mL

Supplier: MORGAN ADVANCED MATERIALS HALD

PLATE FIRM 200X10X200MM 1 * 1 items

Supplier: MACHEREY-NAGEL

NucleoBond Xtra EF Buffer Set I buffer set for the isolation of endotoxin-free low-copy plasmids, BACs, PACs, and P1 constructs, onl y applicable with NucleoBond Xtra EF kits, sufficient for 12 Xtra Maxi preps or 18 Xtra Midi preps - Buffer RES-EF, B 1 * 1 SET

Supplier: SCHUELKE MAYR

MIKROZID AF WIPES JUMBO BOX (220PCS) 1 * 1 kg

Supplier: MACHEREY-NAGEL

NucleoBond Xtra Buffer Set I buffer set for the isolation of low-copy plasmids, BACs, PACs, and P1 constructs, only applicable with NucleoBond Xtra kits, sufficient for 12 Xtra Maxi preps or 18 Xtra Midi preps - Buffer RES, Buffer LYS, Buffer NEU, RN 1 * 1 SET

Supplier: STEMCELL Technologies

Interleukin 21 (IL-21) is a pleiotropic cytokine that is composed of four α-helical bundles and primarily produced by natural killer T (NKT) cells, T follicular helper (Tfh) cells, and Th17 cells (Spolski and Leonard 2008). IL-21 signals via heterodimers of the IL-21 receptor (IL-21R) and the IL2RG-encoded common cytokine receptor γ-chain (Parrish-Novak et al.; Ozaki K et al. 2000), and utilizes the JAK/STAT, MAPK, and PI3K pathways (Spolski and Leonard 2014). IL-21 has been shown to have a critical role in regulating immunoglobulin production and differentiation of the pro-inflammatory Th17 population of cells (Ozaki et al. 2002; Nurieva et al.). Additionally, IL-21 specifically sustains CD8+ T cell effector activity and provides a mechanism of CD4+ T cell help during chronic viral infection (Elsaesser et al.). IL-21 signaling was also found critical for the development of type 1 diabetes in NOD mice (Sutherland et al.) and control of T cell autoimmunity by regulatory B cells (Yoshizaki et al.). This product is animal component-free.

Supplier: STEMCELL Technologies

Interleukin 21 (IL-21) is a pleiotropic cytokine that is composed of four α-helical bundles and primarily produced by natural killer T (NKT) cells, T follicular helper (Tfh) cells, and Th17 cells (Spolski and Leonard 2008). IL-21 signals via heterodimers of the IL-21 receptor (IL-21R) and the IL2RG encoded common cytokine receptor γ-chain (Parrish-Novak et al.; Ozaki K et al. 2000), and utilizes the JAK/STAT, MAPK, and PI3K pathways (Spolski and Leonard 2014). IL-21 has been shown to have a critical role in regulating immunoglobulin production and differentiation of the pro-inflammatory Th17 population of cells (Ozaki et al. 2002; Nurieva et al.). Additionally, IL-21 specifically sustains CD8+ T cell effector activity and provides a mechanism of CD4+ T cell help during chronic viral infection (Elsaesser et al.). IL-21 signaling was also found critical for the development of type 1 diabetes in NOD mice (Sutherland et al.) and control of T cell autoimmunity by regulatory B cells (Yoshizaki et al.).

Supplier: MORGAN ADVANCED MATERIALS HALD

ALSINT TILES SQUARE 150X100X10MM 1 * 1 items

Supplier: Roth Carl

MULTI-GUARD-FILTER-TIPS 0,5-10µl 1 * 960 items

Supplier: Abnova

Recombinant protein, mas1 (np_002368.1) recombinant protein without tag. 1 * 2 µG

Supplier: Restek

Blood Alcohol Mix 0.16 g/dL Forensic Ethanol, Di Water, 1mL, 10pk 1 * 1 Each

Supplier: Abnova

Recombinant protein, opn1sw (aai56720.1) recombinant protein without tag. 1 * 2 µG

Supplier: Abnova

Recombinant protein, gpr12 (np_005279.1) recombinant protein without tag. 1 * 2 µG

Supplier: TRESTON

Middle dividers and plates 1, drawer 70/100 1 * 1 items

Supplier: VACUUBRAND

Pirani-Controller CVC 3000 Set with KF DN 16, for example for RE/RZ 2.5 and RE/RZ 6 with VSP 3000, Vacuum-Valve VV-B 15C, T-Connection, SW DN 15 and more connection parts 1 * 1 SET

Supplier: Thermo Fisher Scientific

Pierce™ Boronic acid resin enables ribonucleotide and oligonucleotide RNA isolation.

Supplier: Portwest

This superb 5-in-1 jacket system is adaptable for any work situation. Outer jacket features 2 large roomy pockets, stud adjustable cuffs and concealed attached roll-away hood. Inner jacket has fluorescent fleece sleeves, comfortable knitted cuffs and 2 side pockets. Both the inner and outer jacket have full EN ISO 20471 Class 3 certification for maximum high visibility protection and safety.

Supplier: STEMCELL Technologies

The platelet-derived growth factor (PDGF) family has five heparin-binding members that assemble into four homodimers (PDGF-AA, PDGF-BB, PDGF-CC, and PDGF-DD) and one heterodimer (PDGF-AB; Fretto et al.; Li and Eriksson). PDGF signals through the receptor tyrosine kinases PDGFRα and PDGFRβ. It has been shown that PDGF-induced migration involves signaling pathways involving MEK/ERK, EGFR, Src, and PI3K/AKT (Kim et al.). PDGF is a potent mitogen for cells of mesenchymal origin, such as fibroblasts, glial cells, and vascular smooth muscle cells. PDGF has been implicated in pathogenesis of atherosclerosis, glomerulonephritis, cancer, and in the contraction of vascular smooth muscle cells of rat aortic tissues (Fretto et al.; Sachinidis et al.). PDGF-BB is secreted by osteoblasts to induce mesenchymal stem cell migration and angiogenesis. It has also been shown that PDGF-BB is secreted by preosteoclasts during bone modeling and remodeling to induce angiogenesis and thus proper osteogenesis (Xie et al.).

Supplier: Merck

(TRIMETHYLSILYLMETHYL)LITHIUM 1.0M SOL 1 * 100 mL

Supplier: MORGAN ADVANCED MATERIALS HALD

Alsint tiles square,150x150x10mm 1 * 1 items

Supplier: MORGAN ADVANCED MATERIALS HALD

Alsint tiles square 200x200x10mm 1 * 1 items

Supplier: Agilent

Syringe 10Ul Rn 23Ga. 1 * 1 items

Supplier: Roth Carl

VIAL WITHOUT SNAPCAP 10ML 1 * 100 items

Supplier: LABCONCO

FLUORESCENT LAMP REPLACEMENT 1 * 1 items

Supplier: STEMCELL Technologies

Interleukin 1 beta (IL-1β) is synthesised as an inactive precursor protein or pro-IL-1β. This precursor is cleaved intracellularly by caspase 1 (IL-1β convertase) to form the active form of the protein that is later secreted (Allan et al.). IL-1β binds to IL-1 receptor and activates intracellular signaling via the MAPK or NF-kB pathway. IL-1β is released by monocytes, tissue macrophages, and dendritic cells in response to infection or injury and induces expression of acute-phase proteins. It also promotes the infiltration of inflammatory and immunocompetent cells from the circulation into the extravascular space and affected tissues, by stimulating the expression of adhesion molecules on endothelial cells. IL-1β also affects other immune cells; for example, it co-stimulates T cell functions together with antigen or mitogen. It also stimulates Th17 differentiation and B cell proliferation in an IL-6-dependent manner. Mice deficient in IL-1β do not show phenotypical differences from wild-type mice; however, they have a reduced response to inflammation, suggesting that IL-1β plays a key role in inflammatory diseases (Dinarello).

Supplier: STEMCELL Technologies

Interleukin 15 (IL-15) is a four-alpha helix bundle cytokine with many similar properties to IL-2. The IL-15 receptor is a heterotrimeric receptor composed of IL-15Ra (the high-affinity receptor for IL-15), as well as IL-2/15Rb (CD122) and common gamma chain (CD132). IL-15 binds to IL-15Rα receptor and can then be presented in trans to IL-2/15Rb and common gamma chain on other cells. Trans-presentation is thought to be the major mechanism by which IL-15-mediated responses occur in mice, although may not be necessary in humans (Castillo et al.). The cytoplasmic domains of IL-2/15Rb and common gamma chain mediate signaling to activate JAK/STAT and PI3K pathways. IL-15 supports the survival and proliferation of naïve CD4+ and CD8+ T cells, and promotes homeostasis of memory T cells. IL-15 also promotes the survival and differentiation of NK cells and regulates their cytolytic activity (Ma et al.). This product is animal component-free.

Supplier: Abnova

Recombinant protein, epcam (np_002345.1) recombinant protein without tag. 1 * 2 µG

Supplier: ELGA LabWater

Consumables Pack for Micra 10µm Depth Filter, 5µm Carbon Filter, Purification Cartridge 1 * 1 items

Supplier: Abnova

Recombinant protein, il2rb (np_000869.1) recombinant protein without tag. 1 * 2 µG

Supplier: Amarell

Viscometer-Therm., ähnlich Vogel-Ossag, ähnlich DIN 12785, 0+35:0,1°C, enclosed scale, capillary tube specially coated inside, with non-wetting blue special liquid, 470mm long, lower part solid stem 200x5mm, 208mm immersion, Richter-top finish, null