133859 Results for: "ProSci Inc."

Supplier: Bioss

STK3: Stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation. Key component of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. STK3/MST2 and STK4/MST1 are required to repress proliferation of mature hepatocytes, to prevent activation of facultative adult liver stem cells (oval cells), and to inhibit tumor formation. Phosphorylates NKX2-1 (By similarity). Phosphorylates NEK2 and plays a role in centrosome disjunction by regulating the localization of NEK2 to centrosome, and its ability to phosphorylate CROCC and CEP250. In conjunction with SAV1, activates the transcriptional activity of ESR1 through the modulation of its phosphorylation. Positively regulates RAF1 activation via suppression of the inhibitory phosphorylation of RAF1 on 'Ser-259'. Phosphorylates MOBKL1A and RASSF2. Phosphorylates MOBKL1B on 'Thr-74'. Acts cooperatively with MOBKL1B to activate STK38.
STK4: Stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation. Key component of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. STK3/MST2 and STK4/MST1 are required to repress proliferation of mature hepatocytes, to prevent activation of facultative adult liver stem cells (oval cells), and to inhibit tumor formation (By similarity). Phosphorylates 'Ser-14' of histone H2B (H2BS14ph) during apoptosis. Phosphorylates FOXO3 upon oxidative stress, which results in its nuclear translocation and cell death initiation. Phosphorylates MOBKL1A, MOBKL1B and RASSF2. Phosphorylates TNNI3 (cardiac Tn-I) and alters its binding affinity to TNNC1 (cardiac Tn-C) and TNNT2 (cardiac Tn-T). Phosphorylates FOXO1 on 'Ser-212' and regulates its activation and stimulates transcription of PMAIP1 in a FOXO1-dependent manner. Phosphorylates SIRT1 and inhibits SIRT1-mediated p53/TP53 deacetylation, thereby promoting p53/TP53 dependent transcription and apoptosis upon DNA damage. Acts as an inhibitor of PKB/AKT1. Phosphorylates AR on 'Ser-650' and suppresses its activity by intersecting with PKB/AKT1 signaling and antagonizing formation of AR-chromatin complexes.

Supplier: Amarell

Precision thermometer made of Quartz-Glass, with ground joint 14,5/23, -10+360:1°C, upper part 350xc.9mm, built-in length 75mm, encl osed scale, cap. colourless, gallium filled, pin-top finish, suitable for government verification 1 * 1 items

Supplier: EGE ELKTRONIK SPEZIAL SENSOREN

SN 450-A4-GA STROMUNGSWACHTER G 1/2INCH Strömungswächter kompakt SN 450 GA Ausführung: G1/2, L=31mm Erfassungsbereich cm/s: 5….150 Ausgang: 4…20mA analog, linear für Wasser Sensorlänge mm: 31 Betriebsspannung V: 24 DC +-10% Last RL: 200..500 Umgebung 1 * 1 ST

Supplier: LABCONCO

4 Purifier Logic+ Class II Type A2 Biosafety Cabinet with 8inch sash opening with a right-side mounted factory-installed service fixture, UV lamp with timer, right-side wall Vacu-Pass Portal and factory installed Ventus canopy kit, 230V, 50/60Hz, Bri 1 * 1 items

Supplier: Thermo Scientific

Total Care Warranty service plan for Bench-Top Incubators & Ovens. Plan provides upgrade to factory warranty coverage includes 2 da y response time*, priority technical support, & one annual preventive maintenance. 1 * 1 items

Supplier: Thermo Scientific

Tech Direct plan service plan for Refrigerated Incubators, Furnaces, Floor-model Incubators & Ovens, where . Plan provides post-warr anty support includes 2 day response time*, full parts and labor coverage*, one annual preventive maintenance. 1 * 1 items

Supplier: Thermo Fisher Scientific

Fresh air particle filter for connection to the fresh air vent for all AP and APS incubators 1 * 1 items

Supplier: Thermo Scientific

Total Care plan service plan for Bench-Top Incubators & Ovens, where . Plan provides post-warranty support includes 3 day response time*, one annual preventive maintenance, and 15% repair discount for parts and labor. 1 * 1 items

Supplier: Aesculap

VARIO-OBERDECKEL F.3/4-CONT., ALU ROT 1 * 1 ST

Supplier: Priorclave

Automatic Cycle Repeat - Includes Automatic Waterfill on electrically heated models 1 * 1 items

Supplier: VARIAN

Low flow concentric glass nebulizer (micromist). 1/pk. provides aspirated free flow of .2 ml/min. includes sample and gas inlet fitt ings 1 * 1 items

Supplier: DWK Life Sciences

Clip for shelf WHEA753685 ( 1 clip ) 1 * 1 items

Supplier: AIR 7 SEAS TRANSPORT LOGISTICS, INC

SILICON GASKET 13.5MM 1 * 1 items

Supplier: ROCHE

SURE/CUT BUFFER L, 1 PAK, HERSTELLER: ROCHE DIAGNOSTICS, HERSTELLER-ARTIKELNUMMER: 11417975001 1 * 5 mL

Supplier: Thermo Scientific

Total Care plan service plan for Refrigerated Incubators, Furnaces, Floor-model Incubators & Ovens, where . Plan provides post-warra nty support includes 3 day response time*, one annual preventive maintenance, and 15% repair discount for parts and 1 * 1 items

Supplier: BDP International Inc.

PCB HEATING CONTROL 1 * 1 items

Supplier: Merck

ZINC IRON OXIDE, NANOPOWDER, <100 NM (B& 1 * 10 g

Supplier: AIR 7 SEAS TRANSPORT LOGISTICS, INC

PUMP 033KW 220-240V 1 * 1 items

Supplier: AIR 7 SEAS TRANSPORT LOGISTICS, INC

CHECK VALVE BSP 3/8in 1 * 1 items

Supplier: ROCHE

SURE/CUT BUFFER SET FOR RESTRICTION ENZYMES, 1 PAK, HERSTELLER: ROCHE DIAGNOSTICS, HERSTELLER-ARTIKELNUMMER: 11082035001 1 * 1 Each

Supplier: AIR 7 SEAS TRANSPORT LOGISTICS, INC

LID ASB 300 1 * 1 items

Supplier: Thermo Scientific

Tech Direct plan service plan for Bench-Top Incubators & Ovens, where . Plan provides post-warranty support includes 2 day response time*, full parts and labor coverage*, one annual preventive maintenance. 1 * 1 items

Supplier: ROCHE

SURE/CUT BUFFER B, 1 PAK, HERSTELLER: ROCHE DIAGNOSTICS, HERSTELLER-ARTIKELNUMMER: 11417967001 1 * 5 mL

Supplier: Thermo Scientific

Total Care Warranty service plan for Refrigerated Incubators, Furnaces, Floor-model Incubators & Ovens. Plan provides upgrade to fac tory warranty coverage includes 2 day response time*, priority technical support, & one annual preventive maintenanc 1 * 1 items

Supplier: ROCHE

SURE/CUT BUFFER M, 1 PAK, HERSTELLER: ROCHE DIAGNOSTICS, HERSTELLER-ARTIKELNUMMER: 11417983001 1 * 5 mL

Supplier: Amarell

General purpose thermometer, enclosed scale, cap. lens front, red special liquid, -10+60:1C, total immersion, 200x7-8mm long, with ring at top 1 * 1 items

Supplier: Priorclave

5 Year Extended Warranty Package, Includes installation and servicing - (UK mainland locations only) 1 * 1 items

Supplier: AIR 7 SEAS TRANSPORT LOGISTICS, INC

DOOR SOLENOID 1 * 1 items

Supplier: ROCHE

SURE/CUT BUFFER H, 1 PAK, HERSTELLER: ROCHE DIAGNOSTICS, HERSTELLER-ARTIKELNUMMER: 11417991001 1 * 5 mL

Supplier: Merck

BIS(TERT-BUTYLIMINO)BIS(DIMETHYLAMINO)T& 1 * 10 g