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133859 results for "ProSci Inc."

133859 Results for: "ProSci Inc."

IQ/OQ document with works test data for chamber, incl. Temperature distribution survey for one free-selectable temperature and humid ity value. 27 measuring points to DIN 12 880: 2007-05, PQ check list as support for validation by customer (models HP 1 * 1 items

Supplier: MEMMERT

IQ/OQ document with works test data for chamber, incl. Temperature distribution survey for one free-selectable temperature and humid ity value. 27 measuring points to DIN 12 880: 2007-05, PQ check list as support for validation by customer (models HP 1 * 1 items

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IQ/OQ document with works test data for chamber, incl. Temperature distribution survey for one free-selectable temperature and humid ity value. 27 measuring points to DIN 12 880: 2007-05, PQ check list as support for validation by customer (models HP 1 * 1 items

Supplier: MEMMERT

IQ/OQ document with works test data for chamber, incl. Temperature distribution survey for one free-selectable temperature and humid ity value. 27 measuring points to DIN 12 880: 2007-05, PQ check list as support for validation by customer (models HP 1 * 1 items

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IQ/OQ document with works test data for chamber, incl. Temperature distribution survey for one free-selectable temperature and humid ity value. 27 measuring points to DIN 12 880: 2007-05, PQ check list as support for validation by customer (models HP 1 * 1 items

Supplier: MEMMERT

IQ/OQ document with works test data for chamber, incl. Temperature distribution survey for one free-selectable temperature and humid ity value. 27 measuring points to DIN 12 880: 2007-05, PQ check list as support for validation by customer (models HP 1 * 1 items

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Liquid electrolyte comb. electrode with Pt 1000 and integrated plastic adapter for hose connection incl. Pg13.5 thread, platinum ju nction, electrolyte L 200, sphere membrane, A-glass, VP screw plug head, length 225 mm, 12 mm Ø, -30...+100°C, 0...14 1 * 1 items

Supplier: SI Analytics

Liquid electrolyte comb. electrode with Pt 1000 and integrated plastic adapter for hose connection incl. Pg13.5 thread, platinum ju nction, electrolyte L 200, sphere membrane, A-glass, VP screw plug head, length 225 mm, 12 mm Ø, -30...+100°C, 0...14 1 * 1 items

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IQ/OQ document with works test data for chamber, incl. Temperature distribution survey for one free-selectable temperature and humid ity value. 27 measuring points to DIN 12 880: 2007-05, PQ check list as support for validation by customer (models HP 1 * 1 items

Supplier: MEMMERT

IQ/OQ document with works test data for chamber, incl. Temperature distribution survey for one free-selectable temperature and humid ity value. 27 measuring points to DIN 12 880: 2007-05, PQ check list as support for validation by customer (models HP 1 * 1 items

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Liquid electrolyte comb. electrode with Pt 1000 and integrated plastic adapter for hose connection incl. Pg13.5 thread, platinum ju nction, electrolyte L 200, sphere membrane, A-glass, VP screw plug head, length 380 mm, 12 mm Ø, -30...+100°C, 0...14 1 * 1 items

Supplier: SI Analytics

Liquid electrolyte comb. electrode with Pt 1000 and integrated plastic adapter for hose connection incl. Pg13.5 thread, platinum ju nction, electrolyte L 200, sphere membrane, A-glass, VP screw plug head, length 380 mm, 12 mm Ø, -30...+100°C, 0...14 1 * 1 items

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Recombinat Protein,Human IgG1 Fc Protein, His Tag,Human IgG Fc, His Tag (IG1-H5225) is expressed from human 293 cells (HEK293). It c ontains AA Glu 99 - Lys 330 (Accession P01857).This protein carries a polyhistidine tag at the C-terminus. The protei 1 * 200 µG

Supplier: ACRO Biosystems

Recombinat Protein,Human IgG1 Fc Protein, His Tag,Human IgG Fc, His Tag (IG1-H5225) is expressed from human 293 cells (HEK293). It c ontains AA Glu 99 - Lys 330 (Accession P01857).This protein carries a polyhistidine tag at the C-terminus. The protei 1 * 200 µG

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Recombinat Protein,Mouse CD3 epsilon Protein, Fc Tag,Mouse CD3E, Fc Tag (CDE-M5256) is expressed from human 293 cells (HEK293). It c ontains AA Asp 23 - Asp 108 (Accession P22646).This protein carries a human IgG1 Fc tag at the C-terminus. The protei 1 * 100 µG

Supplier: ACRO Biosystems

Recombinat Protein,Mouse CD3 epsilon Protein, Fc Tag,Mouse CD3E, Fc Tag (CDE-M5256) is expressed from human 293 cells (HEK293). It c ontains AA Asp 23 - Asp 108 (Accession P22646).This protein carries a human IgG1 Fc tag at the C-terminus. The protei 1 * 100 µG

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Liquid electrolyte comb. electrode with Pt 1000 and integrated plastic adapter for hose connection incl. Pg13.5 thread, platinum ju nction, electrolyte L 300, sphere membrane, S-glass, VP screw plug head, length 120 mm, 12 mm Ø, +10...+135°C, 0...14 1 * 1 items

Supplier: SI Analytics

Liquid electrolyte comb. electrode with Pt 1000 and integrated plastic adapter for hose connection incl. Pg13.5 thread, platinum ju nction, electrolyte L 300, sphere membrane, S-glass, VP screw plug head, length 120 mm, 12 mm Ø, +10...+135°C, 0...14 1 * 1 items

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IQ/OQ document with works test data for chamber, incl. Temperature distribution survey for one free-selectable temperature and humid ity value. 27 measuring points to DIN 12 880: 2007-05, PQ check list as support for validation by customer (models HP 1 * 1 items

Supplier: MEMMERT

IQ/OQ document with works test data for chamber, incl. Temperature distribution survey for one free-selectable temperature and humid ity value. 27 measuring points to DIN 12 880: 2007-05, PQ check list as support for validation by customer (models HP 1 * 1 items

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IGMF 008 GSP - M18x1 5m Kabel 7mm Schaltabstand nb, 120°Dauertemperatur, IP68 (+IP69K), 24 V-DC, incl. 5m Kabel und 2x Flachmutter Nennschaltabstand (mm) 7 nb Betriebsspannung (V) 10…55 DC Umgebungstemperatur (°C) -25…+120 Druckfestigkeit (bar) 10 Sc 1 * 1 ST

Supplier: EGE ELKTRONIK SPEZIAL SENSOREN

IGMF 008 GSP - M18x1 5m Kabel 7mm Schaltabstand nb, 120°Dauertemperatur, IP68 (+IP69K), 24 V-DC, incl. 5m Kabel und 2x Flachmutter Nennschaltabstand (mm) 7 nb Betriebsspannung (V) 10…55 DC Umgebungstemperatur (°C) -25…+120 Druckfestigkeit (bar) 10 Sc 1 * 1 ST

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High temperature bath circulator wch-8, capacity: 8 liter, with digital fuzzy control & digital lcd- back light system, temp. range: ambient +5°c - 250°c, bath dimension: 180 x 320 x 155 mm, pump: 15 l/min., timer: 99 hr. / 59 min., incl. stainless a 1 * 1 items

Supplier: witeg Labortechnik

High temperature bath circulator wch-8, capacity: 8 liter, with digital fuzzy control & digital lcd- back light system, temp. range: ambient +5°c - 250°c, bath dimension: 180 x 320 x 155 mm, pump: 15 l/min., timer: 99 hr. / 59 min., incl. stainless a 1 * 1 items

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Recombinat Protein,Mouse IL-23 R Protein, Fc Tag,Mouse IL-23R, Fc Tag (ILR-M5251) is expressed from human 293 cells (HEK293). It con tains AA Gly 24 - Asp 372 (Accession NP653131).This protein carries a human IgG1 Fc tag at the C-terminus. The protei 1 * 1 mg

Supplier: ACRO Biosystems

Recombinat Protein,Mouse IL-23 R Protein, Fc Tag,Mouse IL-23R, Fc Tag (ILR-M5251) is expressed from human 293 cells (HEK293). It con tains AA Gly 24 - Asp 372 (Accession NP653131).This protein carries a human IgG1 Fc tag at the C-terminus. The protei 1 * 1 mg

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Recombinat Protein,Mouse CD3 epsilon Protein, Fc Tag,Mouse CD3E, Fc Tag (CDE-M5256) is expressed from human 293 cells (HEK293). It c ontains AA Asp 23 - Asp 108 (Accession P22646).This protein carries a human IgG1 Fc tag at the C-terminus. The protei 1 * 1 mg

Supplier: ACRO Biosystems

Recombinat Protein,Mouse CD3 epsilon Protein, Fc Tag,Mouse CD3E, Fc Tag (CDE-M5256) is expressed from human 293 cells (HEK293). It c ontains AA Asp 23 - Asp 108 (Accession P22646).This protein carries a human IgG1 Fc tag at the C-terminus. The protei 1 * 1 mg

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PE-Labeled Human BCMA TNFRSF17 Protein, His Tag Cat. No. BCA-HP2H2 is produced via conjugation of PE to Human BCMA TNFRSF17 Protei n, His Tag under optimal conditions. Human BCMA TNFRSF17 Protein, His Tag is expressed from human 293 cells HEK293. It 1 * 25 Tests

Supplier: ACRO Biosystems

PE-Labeled Human BCMA TNFRSF17 Protein, His Tag Cat. No. BCA-HP2H2 is produced via conjugation of PE to Human BCMA TNFRSF17 Protei n, His Tag under optimal conditions. Human BCMA TNFRSF17 Protein, His Tag is expressed from human 293 cells HEK293. It 1 * 25 Tests

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CHROMABOND QuEChERS Mix I, citrate extraction mix KIT, consisting of:, - 4000 mg MgSO4, - 1000 mg NaCl, - 500 mg Na2H citrate x 1.5 H2O, - 1000 mg Na3 citrate x 2 H2O, individually weighed and filled into aluminium packets, incl. 50 empty 50 mL centr 1 * 6,5 g

Supplier: MACHEREY-NAGEL

CHROMABOND QuEChERS Mix I, citrate extraction mix KIT, consisting of:, - 4000 mg MgSO4, - 1000 mg NaCl, - 500 mg Na2H citrate x 1.5 H2O, - 1000 mg Na3 citrate x 2 H2O, individually weighed and filled into aluminium packets, incl. 50 empty 50 mL centr 1 * 6,5 g

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Mikrogefäße 0,3ml, konisch mit Standring, Höhe 31,8mm, Kleinvolumige Mikroprobengefäße aus Polypropylen, geeignet für die HPLC und GC Probengeber. Verwendbar für die meisten Standard-Autosampler wie Spark Holland, Promis, Marathon, Midas und Triathl 1 * 100 ST

Supplier: NEOLAB

Mikrogefäße 0,3ml, konisch mit Standring, Höhe 31,8mm, Kleinvolumige Mikroprobengefäße aus Polypropylen, geeignet für die HPLC und GC Probengeber. Verwendbar für die meisten Standard-Autosampler wie Spark Holland, Promis, Marathon, Midas und Triathl 1 * 100 ST

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PE-Labeled Human BCMA TNFRSF17 Protein, His Tag Cat. No. BCA-HP2H2 is produced via conjugation of PE to Human BCMA TNFRSF17 Protei n, His Tag under optimal conditions. Human BCMA TNFRSF17 Protein, His Tag is expressed from human 293 cells HEK293. It 1 * 200 Tests

Supplier: ACRO Biosystems

PE-Labeled Human BCMA TNFRSF17 Protein, His Tag Cat. No. BCA-HP2H2 is produced via conjugation of PE to Human BCMA TNFRSF17 Protei n, His Tag under optimal conditions. Human BCMA TNFRSF17 Protein, His Tag is expressed from human 293 cells HEK293. It 1 * 200 Tests

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Recombinat Protein,Mouse IL-23 R Protein, Fc Tag,Mouse IL-23R, Fc Tag (ILR-M5251) is expressed from human 293 cells (HEK293). It con tains AA Gly 24 - Asp 372 (Accession NP653131).This protein carries a human IgG1 Fc tag at the C-terminus. The protei 1 * 100 µG

Supplier: ACRO Biosystems

Recombinat Protein,Mouse IL-23 R Protein, Fc Tag,Mouse IL-23R, Fc Tag (ILR-M5251) is expressed from human 293 cells (HEK293). It con tains AA Gly 24 - Asp 372 (Accession NP653131).This protein carries a human IgG1 Fc tag at the C-terminus. The protei 1 * 100 µG

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Shaker KM CO2 - FL 2.245,00 40,00 1.347,00 incl. basic platform and rubber mat Ideal for use in CO2 incubators Shaking motion: orbital Shakting platform: 200 x 295 mm Max. Loading: 2 kg Shakting speed: 5 - 220 rpm (in steps of 5) Stroke: 20 mm CO2 co 1 * 1 items

Supplier: Edmund Bühler GmbH

Shaker KM CO2 - FL 2.245,00 40,00 1.347,00 incl. basic platform and rubber mat Ideal for use in CO2 incubators Shaking motion: orbital Shakting platform: 200 x 295 mm Max. Loading: 2 kg Shakting speed: 5 - 220 rpm (in steps of 5) Stroke: 20 mm CO2 co 1 * 1 items

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WEISS Norm: EN 388 Träger: 60% Baumwolle/40% Polyester, weiß Beschichtung: Vinyl-Noppen, schwarz - Profi-Qualität - Grobstrick, nahtlos/ 7G - schwarze Grip-Noppen auf der Innenhandfläche und dem Handrücken - sehr gute Passform und sicherer Griff - at 1 * 240 PAAR

Supplier: FELDTMANN HELMUT

WEISS Norm: EN 388 Träger: 60% Baumwolle/40% Polyester, weiß Beschichtung: Vinyl-Noppen, schwarz - Profi-Qualität - Grobstrick, nahtlos/ 7G - schwarze Grip-Noppen auf der Innenhandfläche und dem Handrücken - sehr gute Passform und sicherer Griff - at 1 * 240 PAAR

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WEISS Norm: EN 388 Träger: 60% Baumwolle/40% Polyester, weiß Beschichtung: Vinyl-Noppen, schwarz - Profi-Qualität - Grobstrick, nahtlos/ 7G - schwarze Grip-Noppen auf der Innenhandfläche und dem Handrücken - sehr gute Passform und sicherer Griff - at 1 * 240 PAAR

Supplier: FELDTMANN HELMUT

WEISS Norm: EN 388 Träger: 60% Baumwolle/40% Polyester, weiß Beschichtung: Vinyl-Noppen, schwarz - Profi-Qualität - Grobstrick, nahtlos/ 7G - schwarze Grip-Noppen auf der Innenhandfläche und dem Handrücken - sehr gute Passform und sicherer Griff - at 1 * 240 PAAR

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WEISS Norm: EN 388 Träger: 60% Baumwolle/40% Polyester, weiß Beschichtung: Vinyl-Noppen, schwarz - Profi-Qualität - Grobstrick, nahtlos/ 7G - schwarze Grip-Noppen auf der Innenhandfläche und dem Handrücken - sehr gute Passform und sicherer Griff - at 1 * 240 PAAR

Supplier: FELDTMANN HELMUT

WEISS Norm: EN 388 Träger: 60% Baumwolle/40% Polyester, weiß Beschichtung: Vinyl-Noppen, schwarz - Profi-Qualität - Grobstrick, nahtlos/ 7G - schwarze Grip-Noppen auf der Innenhandfläche und dem Handrücken - sehr gute Passform und sicherer Griff - at 1 * 240 PAAR

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Rocker 300 oil-free vacuum pump,lubricant and oil free piston, maintenance-free,ProteTM filter, thermal protection device, CE certified ,AC 230 V, max. vacuum -680 mmHg, flow rate 20 l/min, motor ratio 1450 rpm, 1/8 HP, port thread 5/16 inch (8 mm), 1 * 1 items

Supplier: witeg Labortechnik

Rocker 300 oil-free vacuum pump,lubricant and oil free piston, maintenance-free,ProteTM filter, thermal protection device, CE certified ,AC 230 V, max. vacuum -680 mmHg, flow rate 20 l/min, motor ratio 1450 rpm, 1/8 HP, port thread 5/16 inch (8 mm), 1 * 1 items

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KIT, ANCA SCREEN ELISA KIT, ANCABSCREEN ELISA KIT IS A QUALITATIVE ASSAY INTENDED TO SCREEN FOR THE PRESENCE OF IGG CLASS AUTOANTIBO DIES AGAINST PR3 AND MPO IN HUMAN SERUM OR PLASMA. 1 * 1 KIT

Supplier: Abnova

KIT, ANCA SCREEN ELISA KIT, ANCABSCREEN ELISA KIT IS A QUALITATIVE ASSAY INTENDED TO SCREEN FOR THE PRESENCE OF IGG CLASS AUTOANTIBO DIES AGAINST PR3 AND MPO IN HUMAN SERUM OR PLASMA. 1 * 1 KIT

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Sandwich Elisa kit for Quantitative Detection for Human Clusterin, Clusterin apolipoprotein J is a 75-80 kDa disulfide-linked hetero dimeric protein associated with the clearance of cellular debris and apoptosis. In humans, clusterin is enco 1 * 96 Tests

Supplier: Biorbyt

Sandwich Elisa kit for Quantitative Detection for Human Clusterin, Clusterin apolipoprotein J is a 75-80 kDa disulfide-linked hetero dimeric protein associated with the clearance of cellular debris and apoptosis. In humans, clusterin is enco 1 * 96 Tests

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Sandwich Elisa kit for Quantitative Detection for Mouse Clusterin, Clusterin apolipoprotein J is a 75-80 kDa disulfide-linked hetero dimeric protein associated with the clearance of cellular debris and apoptosis. In humans, clusterin is enco 1 * 96 Tests

Supplier: Biorbyt

Sandwich Elisa kit for Quantitative Detection for Mouse Clusterin, Clusterin apolipoprotein J is a 75-80 kDa disulfide-linked hetero dimeric protein associated with the clearance of cellular debris and apoptosis. In humans, clusterin is enco 1 * 96 Tests

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Anti-STK3+STK4 Rabbit Polyclonal Antibody (Alexa Fluor® 680)

Supplier: Bioss

STK3: Stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation. Key component of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. STK3/MST2 and STK4/MST1 are required to repress proliferation of mature hepatocytes, to prevent activation of facultative adult liver stem cells (oval cells), and to inhibit tumor formation. Phosphorylates NKX2-1 (By similarity). Phosphorylates NEK2 and plays a role in centrosome disjunction by regulating the localization of NEK2 to centrosome, and its ability to phosphorylate CROCC and CEP250. In conjunction with SAV1, activates the transcriptional activity of ESR1 through the modulation of its phosphorylation. Positively regulates RAF1 activation via suppression of the inhibitory phosphorylation of RAF1 on 'Ser-259'. Phosphorylates MOBKL1A and RASSF2. Phosphorylates MOBKL1B on 'Thr-74'. Acts cooperatively with MOBKL1B to activate STK38.
STK4: Stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation. Key component of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. STK3/MST2 and STK4/MST1 are required to repress proliferation of mature hepatocytes, to prevent activation of facultative adult liver stem cells (oval cells), and to inhibit tumor formation (By similarity). Phosphorylates 'Ser-14' of histone H2B (H2BS14ph) during apoptosis. Phosphorylates FOXO3 upon oxidative stress, which results in its nuclear translocation and cell death initiation. Phosphorylates MOBKL1A, MOBKL1B and RASSF2. Phosphorylates TNNI3 (cardiac Tn-I) and alters its binding affinity to TNNC1 (cardiac Tn-C) and TNNT2 (cardiac Tn-T). Phosphorylates FOXO1 on 'Ser-212' and regulates its activation and stimulates transcription of PMAIP1 in a FOXO1-dependent manner. Phosphorylates SIRT1 and inhibits SIRT1-mediated p53/TP53 deacetylation, thereby promoting p53/TP53 dependent transcription and apoptosis upon DNA damage. Acts as an inhibitor of PKB/AKT1. Phosphorylates AR on 'Ser-650' and suppresses its activity by intersecting with PKB/AKT1 signaling and antagonizing formation of AR-chromatin complexes.

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4ft Logic Class II, Type A2 Biosafety Cabinet with 8inch sash, right-side service fixture, UV, right and left side Vacu-Pass Portals and base stand, 230V, 50/60Hz, Great Britain 1 * 1 items

Supplier: LABCONCO

4ft Logic Class II, Type A2 Biosafety Cabinet with 8inch sash, right-side service fixture, UV, right and left side Vacu-Pass Portals and base stand, 230V, 50/60Hz, Great Britain 1 * 1 items

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Anti-STK3+STK4 Rabbit Polyclonal Antibody (Alexa Fluor® 750)

Supplier: Bioss

STK3: Stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation. Key component of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. STK3/MST2 and STK4/MST1 are required to repress proliferation of mature hepatocytes, to prevent activation of facultative adult liver stem cells (oval cells), and to inhibit tumor formation. Phosphorylates NKX2-1 (By similarity). Phosphorylates NEK2 and plays a role in centrosome disjunction by regulating the localization of NEK2 to centrosome, and its ability to phosphorylate CROCC and CEP250. In conjunction with SAV1, activates the transcriptional activity of ESR1 through the modulation of its phosphorylation. Positively regulates RAF1 activation via suppression of the inhibitory phosphorylation of RAF1 on 'Ser-259'. Phosphorylates MOBKL1A and RASSF2. Phosphorylates MOBKL1B on 'Thr-74'. Acts cooperatively with MOBKL1B to activate STK38.
STK4: Stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation. Key component of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. STK3/MST2 and STK4/MST1 are required to repress proliferation of mature hepatocytes, to prevent activation of facultative adult liver stem cells (oval cells), and to inhibit tumor formation (By similarity). Phosphorylates 'Ser-14' of histone H2B (H2BS14ph) during apoptosis. Phosphorylates FOXO3 upon oxidative stress, which results in its nuclear translocation and cell death initiation. Phosphorylates MOBKL1A, MOBKL1B and RASSF2. Phosphorylates TNNI3 (cardiac Tn-I) and alters its binding affinity to TNNC1 (cardiac Tn-C) and TNNT2 (cardiac Tn-T). Phosphorylates FOXO1 on 'Ser-212' and regulates its activation and stimulates transcription of PMAIP1 in a FOXO1-dependent manner. Phosphorylates SIRT1 and inhibits SIRT1-mediated p53/TP53 deacetylation, thereby promoting p53/TP53 dependent transcription and apoptosis upon DNA damage. Acts as an inhibitor of PKB/AKT1. Phosphorylates AR on 'Ser-650' and suppresses its activity by intersecting with PKB/AKT1 signaling and antagonizing formation of AR-chromatin complexes.

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