133860 Results for: "ProSci Inc."

Supplier: Bioss

IFN-induced dsRNA-dependent serine/threonine-protein kinase which plays a key role in the innate immune response to viral infection and is also involved in the regulation of signal transduction, apoptosis, cell proliferation and differentiation. Exerts its antiviral activity on a wide range of DNA and RNA viruses including hepatitis C virus (HCV), hepatitis B virus (HBV), measles virus (MV) and herpes simplex virus 1 (HHV-1). Inhibits viral replication via phosphorylation of the alpha subunit of eukaryotic initiation factor 2 (EIF2S1), this phosphorylation impairs the recycling of EIF2S1 between successive rounds of initiation leading to inhibition of translation which eventually results in shutdown of cellular and viral protein synthesis. Also phosphorylates other substrates including p53/TP53, PPP2R5A, DHX9, ILF3, IRS1 and the HHV-1 viral protein US11. In addition to serine/threonine-protein kinase activity, also has tyrosine-protein kinase activity and phosphorylates CDK1 at 'Tyr-4' upon DNA damage, facilitating its ubiquitination and proteosomal degradation. Either as an adapter protein and/or via its kinase activity, can regulate various signaling pathways (p38 MAP kinase, NF-kappa-B and insulin signaling pathways) and transcription factors (JUN, STAT1, STAT3, IRF1, ATF3) involved in the expression of genes encoding proinflammatory cytokines and IFNs. Activates the NF-kappa-B pathway via interaction with IKBKB and TRAF family of proteins and activates the p38 MAP kinase pathway via interaction with MAP2K6. Can act as both a positive and negative regulator of the insulin signaling pathway (ISP). Negatively regulates ISP by inducing the inhibitory phosphorylation of insulin receptor substrate 1 (IRS1) at 'Ser-312' and positively regulates ISP via phosphorylation of PPP2R5A which activates FOXO1, which in turn up-regulates the expression of insulin receptor substrate 2 (IRS2).

Supplier: Bioss

IFN-induced dsRNA-dependent serine/threonine-protein kinase which plays a key role in the innate immune response to viral infection and is also involved in the regulation of signal transduction, apoptosis, cell proliferation and differentiation. Exerts its antiviral activity on a wide range of DNA and RNA viruses including hepatitis C virus (HCV), hepatitis B virus (HBV), measles virus (MV) and herpes simplex virus 1 (HHV-1). Inhibits viral replication via phosphorylation of the alpha subunit of eukaryotic initiation factor 2 (EIF2S1), this phosphorylation impairs the recycling of EIF2S1 between successive rounds of initiation leading to inhibition of translation which eventually results in shutdown of cellular and viral protein synthesis. Also phosphorylates other substrates including p53/TP53, PPP2R5A, DHX9, ILF3, IRS1 and the HHV-1 viral protein US11. In addition to serine/threonine-protein kinase activity, also has tyrosine-protein kinase activity and phosphorylates CDK1 at 'Tyr-4' upon DNA damage, facilitating its ubiquitination and proteosomal degradation. Either as an adapter protein and/or via its kinase activity, can regulate various signaling pathways (p38 MAP kinase, NF-kappa-B and insulin signaling pathways) and transcription factors (JUN, STAT1, STAT3, IRF1, ATF3) involved in the expression of genes encoding proinflammatory cytokines and IFNs. Activates the NF-kappa-B pathway via interaction with IKBKB and TRAF family of proteins and activates the p38 MAP kinase pathway via interaction with MAP2K6. Can act as both a positive and negative regulator of the insulin signaling pathway (ISP). Negatively regulates ISP by inducing the inhibitory phosphorylation of insulin receptor substrate 1 (IRS1) at 'Ser-312' and positively regulates ISP via phosphorylation of PPP2R5A which activates FOXO1, which in turn up-regulates the expression of insulin receptor substrate 2 (IRS2).

Supplier: Bioss

Involved in translation as a component of the 40S small ribosomal subunit (PubMed:8706699). Has endonuclease activity and plays a role in repair of damaged DNA (PubMed:7775413). Cleaves phosphodiester bonds of DNAs containing altered bases with broad specificity and cleaves supercoiled DNA more efficiently than relaxed DNA (PubMed:15707971). Displays high binding affinity for 7,8-dihydro-8-oxoguanine (8-oxoG), a common DNA lesion caused by reactive oxygen species (ROS) (PubMed:14706345). Has also been shown to bind with similar affinity to intact and damaged DNA (PubMed:18610840). Stimulates the N-glycosylase activity of the base excision protein OGG1 (PubMed:15518571). Enhances the uracil excision activity of UNG1 (PubMed:18973764). Also stimulates the cleavage of the phosphodiester backbone by APEX1 (PubMed:18973764). When located in the mitochondrion, reduces cellular ROS levels and mitochondrial DNA damage (PubMed:23911537). Has also been shown to negatively regulate DNA repair in cells exposed to hydrogen peroxide (PubMed:17049931). Plays a role in regulating transcription as part of the NF-kappa-B p65-p50 complex where it binds to the RELA/p65 subunit, enhances binding of the complex to DNA and promotes transcription of target genes (PubMed:18045535). Represses its own translation by binding to its cognate mRNA (PubMed:20217897). Binds to and protects TP53/p53 from MDM2-mediated ubiquitination (PubMed:19656744). Involved in spindle formation and chromosome movement during mitosis by regulating microtubule polymerization (PubMed:23131551). Involved in induction of apoptosis through its role in activation of CASP8 (PubMed:14988002). Induces neuronal apoptosis by interacting with the E2F1 transcription factor and acting synergistically with it to up-regulate pro-apoptotic proteins BCL2L11/BIM and HRK/Dp5 (PubMed:20605787). Interacts with TRADD following exposure to UV radiation and induces apoptosis by caspase-dependent JNK activation (PubMed:22510408).

Supplier: Bioss

IFN-induced dsRNA-dependent serine/threonine-protein kinase which plays a key role in the innate immune response to viral infection and is also involved in the regulation of signal transduction, apoptosis, cell proliferation and differentiation. Exerts its antiviral activity on a wide range of DNA and RNA viruses including hepatitis C virus (HCV), hepatitis B virus (HBV), measles virus (MV) and herpes simplex virus 1 (HHV-1). Inhibits viral replication via phosphorylation of the alpha subunit of eukaryotic initiation factor 2 (EIF2S1), this phosphorylation impairs the recycling of EIF2S1 between successive rounds of initiation leading to inhibition of translation which eventually results in shutdown of cellular and viral protein synthesis. Also phosphorylates other substrates including p53/TP53, PPP2R5A, DHX9, ILF3, IRS1 and the HHV-1 viral protein US11. In addition to serine/threonine-protein kinase activity, also has tyrosine-protein kinase activity and phosphorylates CDK1 at 'Tyr-4' upon DNA damage, facilitating its ubiquitination and proteosomal degradation. Either as an adapter protein and/or via its kinase activity, can regulate various signaling pathways (p38 MAP kinase, NF-kappa-B and insulin signaling pathways) and transcription factors (JUN, STAT1, STAT3, IRF1, ATF3) involved in the expression of genes encoding proinflammatory cytokines and IFNs. Activates the NF-kappa-B pathway via interaction with IKBKB and TRAF family of proteins and activates the p38 MAP kinase pathway via interaction with MAP2K6. Can act as both a positive and negative regulator of the insulin signaling pathway (ISP). Negatively regulates ISP by inducing the inhibitory phosphorylation of insulin receptor substrate 1 (IRS1) at 'Ser-312' and positively regulates ISP via phosphorylation of PPP2R5A which activates FOXO1, which in turn up-regulates the expression of insulin receptor substrate 2 (IRS2).

Supplier: Bioss

Involved in translation as a component of the 40S small ribosomal subunit (PubMed:8706699). Has endonuclease activity and plays a role in repair of damaged DNA (PubMed:7775413). Cleaves phosphodiester bonds of DNAs containing altered bases with broad specificity and cleaves supercoiled DNA more efficiently than relaxed DNA (PubMed:15707971). Displays high binding affinity for 7,8-dihydro-8-oxoguanine (8-oxoG), a common DNA lesion caused by reactive oxygen species (ROS) (PubMed:14706345). Has also been shown to bind with similar affinity to intact and damaged DNA (PubMed:18610840). Stimulates the N-glycosylase activity of the base excision protein OGG1 (PubMed:15518571). Enhances the uracil excision activity of UNG1 (PubMed:18973764). Also stimulates the cleavage of the phosphodiester backbone by APEX1 (PubMed:18973764). When located in the mitochondrion, reduces cellular ROS levels and mitochondrial DNA damage (PubMed:23911537). Has also been shown to negatively regulate DNA repair in cells exposed to hydrogen peroxide (PubMed:17049931). Plays a role in regulating transcription as part of the NF-kappa-B p65-p50 complex where it binds to the RELA/p65 subunit, enhances binding of the complex to DNA and promotes transcription of target genes (PubMed:18045535). Represses its own translation by binding to its cognate mRNA (PubMed:20217897). Binds to and protects TP53/p53 from MDM2-mediated ubiquitination (PubMed:19656744). Involved in spindle formation and chromosome movement during mitosis by regulating microtubule polymerization (PubMed:23131551). Involved in induction of apoptosis through its role in activation of CASP8 (PubMed:14988002). Induces neuronal apoptosis by interacting with the E2F1 transcription factor and acting synergistically with it to up-regulate pro-apoptotic proteins BCL2L11/BIM and HRK/Dp5 (PubMed:20605787). Interacts with TRADD following exposure to UV radiation and induces apoptosis by caspase-dependent JNK activation (PubMed:22510408).

Supplier: Bioss

IFN-induced dsRNA-dependent serine/threonine-protein kinase which plays a key role in the innate immune response to viral infection and is also involved in the regulation of signal transduction, apoptosis, cell proliferation and differentiation. Exerts its antiviral activity on a wide range of DNA and RNA viruses including hepatitis C virus (HCV), hepatitis B virus (HBV), measles virus (MV) and herpes simplex virus 1 (HHV-1). Inhibits viral replication via phosphorylation of the alpha subunit of eukaryotic initiation factor 2 (EIF2S1), this phosphorylation impairs the recycling of EIF2S1 between successive rounds of initiation leading to inhibition of translation which eventually results in shutdown of cellular and viral protein synthesis. Also phosphorylates other substrates including p53/TP53, PPP2R5A, DHX9, ILF3, IRS1 and the HHV-1 viral protein US11. In addition to serine/threonine-protein kinase activity, also has tyrosine-protein kinase activity and phosphorylates CDK1 at 'Tyr-4' upon DNA damage, facilitating its ubiquitination and proteosomal degradation. Either as an adapter protein and/or via its kinase activity, can regulate various signaling pathways (p38 MAP kinase, NF-kappa-B and insulin signaling pathways) and transcription factors (JUN, STAT1, STAT3, IRF1, ATF3) involved in the expression of genes encoding proinflammatory cytokines and IFNs. Activates the NF-kappa-B pathway via interaction with IKBKB and TRAF family of proteins and activates the p38 MAP kinase pathway via interaction with MAP2K6. Can act as both a positive and negative regulator of the insulin signaling pathway (ISP). Negatively regulates ISP by inducing the inhibitory phosphorylation of insulin receptor substrate 1 (IRS1) at 'Ser-312' and positively regulates ISP via phosphorylation of PPP2R5A which activates FOXO1, which in turn up-regulates the expression of insulin receptor substrate 2 (IRS2).

Supplier: Bioss

Membrane Receptors Transforming growth factor beta is a multifunctional cytokine known to modulate several tissue development and repair processes, including cell differentiation, cell cycle progression, cellular migration, adhesion, and extracellular matrix production. There are 3 forms encoded by separate genes TGFB1, TGFB2, and TGFB3. The diverse effects of TGF beta are mediated by the TGF beta receptors and cell surface binding proteins. In addition to type I TGF beta receptor (TGFBR1) and type II (TFGBR2), type III (TGF beta III receptor) has been identified. It is a glycoprotein that binds TGF beta and exists in both a membrane bound and a soluble form. It may serve as a receptor accessory molecule in both the TGF beta and fibroblast growth factor systems. TGF beta III receptor lacks a recognizable signaling domain and has no clearly defined role in TGF beta signaling. Endothelial cells undergoing epithelial mesenchymal transformation express TGF beta III receptor, and TGF beta III receptor specific antisera inhibits mesenchyme formation and migration. Misexpression of TGF beta III receptor in nontransforming ventricular endothelial cells conferrs transformation in response to TGFB2. These results support a model where TGF beta III receptor localizes transformation in the heart and plays an essential, nonredundant role in TGF beta signaling. TGF beta III receptor, or beta glycan, can function as an inhibin coreceptor with ActRII. TGF beta III receptor binds inhibin with high affinity and enhances binding in cells coexpressing ActRII and TGF beta III receptor. Inhibin forms crosslinked complexes with both recombinant and endogenously expressed TGF beta III receptor and ActRII. TGF beta III receptor confers inhibin sensitivity to cell lines that otherwise respond poorly to this hormone.

Supplier: HAMMERBACHER

Standcontainer SC50 KR, 80er Tiefe, Korpus: Nussbaum / Front: Nussbaum, 42, 8 x 72 - 76 x 80 cm, 1/3/3/3/3 HE, Zentralverriegelung, Auszugsperre, Kreuzgriff KR, Metall, ORGA-Schublade, 25kg belastbar, Teilauszug 80%, Selbsteinzug, incl. 4 Schübe, ver 1 * 1 ST

Supplier: HAMMERBACHER

Rollcontainer AC30 SG, 60er Tiefe, Korpus: Nussbaum / Front: Nussbaum, 42, 8 x 58 x 59 cm, 1/3/3/3 HE, Zentralverriegelung, Auszugsp erre, Streifengriff SG, Kunststoff, ORGA-Schublade, 25kg belastbar, Teilauszug 80%, Selbsteinzug, incl. 3 Schübe, ver 1 * 1 ST

Supplier: HAMMERBACHER

Rollcontainer TC30 KR, 80er Tiefe, Korpus: Nussbaum / Front: Nussbaum, 42, 8 x 51, 2 x 80 cm, 1/2/3/3 HE, Zentralverriegelung, Auszu gsperre, Kreuzgriff KR, Metall, ORGA-Schublade, 25kg belastbar, Teilauszug 75%, Selbsteinzug, incl. 3 Schübe, verleim 1 * 1 ST

Supplier: Biorbyt

GMF-Gamma (GMF-Gamma) Human Recombinant produced in E.coli is signle, non-glycosylated, polypeptide chain containing 142 amino acids and having total molecular mass of 16.8 kDa. GMF-Gamma, GMF-Gamma, Human Recombinant is purified by proprie 1 * 20 µG

Supplier: MEMMERT

Active microprocessor control for humidifying and dehumidifying (40 – 97 % rh), incl. digital indication and auto-diagnostic system ensures even more rapid reaching of set humidity and very short recovery times while avoiding condensate formation. hu 1 * 1 items

Supplier: HAMMERBACHER

Rollcontainer AC30 BM, 60er Tiefe, Korpus: Nussbaum / Front: Nussbaum, 42, 8 x 58 x 59 cm, 1/3/3/3 HE, Zentralverriegelung, Auszugsp erre, Bogengriff BM, Metall, ORGA-Schublade, 25kg belastbar, Teilauszug 80%, Selbsteinzug, incl. 3 Schübe, verleimt, 1 * 1 ST

Supplier: HAMMERBACHER

Rollcontainer AC30 CE, 60er Tiefe, Korpus: Nussbaum / Front: Nussbaum, 42, 8 x 58 x 59 cm, 1/3/3/3 HE, Zentralverriegelung, Auszugsp erre, Chromgriff CE, Metall, ORGA-Schublade, 25kg belastbar, Teilauszug 80%, Selbsteinzug, incl. 3 Schübe, verleimt, 1 * 1 ST

Supplier: HAMMERBACHER

Standcontainer SC50 NU, 80er Tiefe, Korpus: Nussbaum / Front: Nussbaum, 42, 8 x 72 - 76 x 80 cm, 1/3/3/3/3 HE, Zentralverriegelung, Auszugsperre, Nutgriff NU, Metall, ORGA-Schublade, 25kg belastbar, Teilauszug 80%, Selbsteinzug, incl. 4 Schübe, verle 1 * 1 ST

Supplier: HAMMERBACHER

Konferenztisch KT28C, 280 x 130 cm, Platte: weiß, 25mm dick, 2 mm Duo-Kante, tonnenförmig, Sechs-Fuß-Gestell verchromt, Rundrohr 6 c m, Arbeitshöhe 72-74 cm, incl. 1 Kabelauslass 6 cm, mittig, Anlieferzustand: zerlegt, einfache Montage 1 * 1 ST

Supplier: MEMMERT

Active microprocessor control for humidifying and dehumidifying (40 – 97 % rh), incl. digital indication and auto-diagnostic system ensures even more rapid reaching of set humidity and very short recovery times while avoiding condensate formation. hu 1 * 1 items

Supplier: HAMMERBACHER

Standcontainer SC50 CE, 80er Tiefe, Korpus: Nussbaum / Front: Nussbaum, 42, 8 x 72 - 76 x 80 cm, 1/3/3/3/3 HE, Zentralverriegelung, Auszugsperre, Chromgriff CE, Metall, ORGA-Schublade, 25kg belastbar, Teilauszug 80%, Selbsteinzug, incl. 4 Schübe, ver 1 * 1 ST

Supplier: HAMMERBACHER

Standcontainer SC50 WE, 80er Tiefe, Korpus: Nussbaum / Front: Nussbaum, 42, 8 x 72 - 76 x 80 cm, 1/3/3/3/3 HE, Zentralverriegelung, Auszugsperre, Wellengriff WE, Metall, ORGA-Schublade, 25kg belastbar, Teilauszug 80%, Selbsteinzug, incl. 4 Schübe, ve 1 * 1 ST

Supplier: ACRO Biosystems

Recombinat Protein,Human FGF-9 Protein, Fc Tag,Recombinant human FGF9 Fc chimera (rhFGF9-Fc) Leu4-Ser208 (Accession AAI03979) was pr oduced in human HEK293 cells at ACRObiosystems.This protein carries a human IgG1 Fc tag at the N-terminus. The protei 1 * 1 mg

Supplier: HAMMERBACHER

Standcontainer SC50 KR, 80er Tiefe, Korpus: Zwetschge / Front: weiß, 42, 8 x 72 - 76 x 80 cm, 1/3/3/3/3 HE, Zentralverriegelung, Aus zugsperre, Kreuzgriff KR, Metall, ORGA-Schublade, 25kg belastbar, Teilauszug 80%, Selbsteinzug, incl. 4 Schübe, verle 1 * 1 ST

Supplier: HAMMERBACHER

Standcontainer SC50 CE, 80er Tiefe, Korpus: Zwetschge / Front: weiß, 42, 8 x 72 - 76 x 80 cm, 1/3/3/3/3 HE, Zentralverriegelung, Aus zugsperre, Chromgriff CE, Metall, ORGA-Schublade, 25kg belastbar, Teilauszug 80%, Selbsteinzug, incl. 4 Schübe, verle 1 * 1 ST

Supplier: HAMMERBACHER

Konferenztisch KT28C, 280 x 130 cm, Platte: Zwetschge, 25mm dick, 2 mm Duo-Kante, tonnenförmig, Sechs-Fuß-Gestell verchromt, Rundroh r 6 cm, Arbeitshöhe 72-74 cm, incl. 1 Kabelauslass 6 cm, mittig, Anlieferzustand: zerlegt, einfache Montage 1 * 1 ST

Supplier: HAMMERBACHER

Konferenztisch KT28C, 280 x 130 cm, Platte: Buche, 25mm dick, 2 mm ABS-Kante, tonnenförmig, Sechs-Fuß-Gestell verchromt, Rundrohr 6 cm, Arbeitshöhe 72-74 cm, incl. 1 Kabelauslass 6 cm, mittig, Anlieferzustand: zerlegt, einfache Montage 1 * 1 ST

Supplier: PerkinElmer

Elite-bac advantage columns are exceptionally robust, ensuring longer column lifetime and highly reproducible data for analysis of b lood alcohol content (bac). inner diameter (mm i.d): 0.18 length (m): 10 film thickness (?m): 1.00. key benefits incl 1 * 1 items

Supplier: VARIAN

Hi-sens hf+tds sample intro kit rad icp. high sensitivity, inert sample intro kit for hf/high tds with 7 series radial icp. incl ine rt sturman masters s/chamber, oneneb + fep transfer tube 1 * 1 items

Supplier: HAMMERBACHER

Standcontainer SC50 NU, 80er Tiefe, Korpus: Zwetschge / Front: weiß, 42, 8 x 72 - 76 x 80 cm, 1/3/3/3/3 HE, Zentralverriegelung, Aus zugsperre, Nutgriff NU, Metall, ORGA-Schublade, 25kg belastbar, Teilauszug 80%, Selbsteinzug, incl. 4 Schübe, verleim 1 * 1 ST

Supplier: PerkinElmer

Elite-bac advantage columns are exceptionally robust, ensuring longer column lifetime and highly reproducible data for analysis of b lood alcohol content (bac). inner diameter (mm i.d): 0.53 length (m): 30 film thickness (?m): 1.00. key benefits incl 1 * 1 items

Supplier: HAMMERBACHER

Konferenztisch KT28C, 280 x 130 cm, Platte: Ahorn, 25mm dick, 2 mm ABS-Kante, tonnenförmig, Sechs-Fuß-Gestell verchromt, Rundrohr 6 cm, Arbeitshöhe 72-74 cm, incl. 1 Kabelauslass 6 cm, mittig, Anlieferzustand: zerlegt, einfache Montage 1 * 1 ST

Supplier: OLYMPUS OPTICAL

DP23M-CU-1-2 monochrome camera 6.4 Mpx, 1/1.8 inch, backside illuminated monochrome CMOS Camera for C-mount adaption, no cooling, USB 3.1 interface. Including: camera head, USB 3.1 cable and safety instructions. Supported by cellSens and DP2-TWAIN 1 * 1 items