113380 Results for: "PerkinElmer&pageNo=10&view=easy"
SINGLE-PHASE ELECTRIC CONNECTION 1 * 1 items
Supplier: SMEG
SINGLE-PHASE ELECTRIC CONNECTION 1 * 1 items
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Human Recombinant RANKL
Supplier: STEMCELL Technologies
Receptor activator of nuclear factor kappa-B ligand (RANKL) is a member of the tumor necrosis factor (TNF) superfamily (Anderson et al.). Cytokines in the TNF superfamily are involved in a variety of long-term cellular activities such as differentiation, proliferation, and cell death (MacEwan). RANKL is a type II homotrimeric transmembrane protein expressed in both a membrane-bound and secreted form (Ikeda et al.). RANKL binds to the receptor activator of nuclear factor kappa-B (RANK). Upon binding to its receptor, RANKL activates the AKT signaling pathway (Moon et al.). Osteoprotegerin (OPG) may also bind RANKL, and this binding competes with RANKL-RANK binding (Lacey et al.). RANKL is involved in osteoclastogenesis (Lacey et al.; Yasuda et al.) and T cell activation (Wong et al.).
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Human Recombinant Betacellulin
Supplier: STEMCELL Technologies
Betacellulin is a member of the epidermal growth factor (EGF) family, and signals through EGF receptor and ERBB4. It activates ERK and AKT pathways, which induces neural stem cell proliferation and prevents spontaneous differentiation in culture. Betacellulin stimulates the expansion of neural stem cells, transit-amplifying cells, and neuroblasts derived from subventricular zone and dentate gyrus (Gómez-Gaviro et al.). It is a potent mitogen for retinal pigment epithelial cells and vascular smooth muscle cells. Betacellulin down-regulates E-cadherin expression in ovarian cancer cell lines via MEK/ERK1/2 and PI3K/AKT signaling pathways, thus increasing cell migration (Zhao et al.). It is a modulator of interferon (IFN) response and enhances anti-viral effects of IFN (Al-Yahya et al.). Betacellulin is expressed in pancreatic α cells, β cells, and duct cells. It induces the proliferation of pancreatic cancer cell lines, inhibits apoptosis, promotes the neogenesis of β cells, and converts non-β cells into insulin-producing cells (Kawaguchi et al.; Miyagawa al.; Saito et al.).
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Human Recombinant IL-9
Supplier: STEMCELL Technologies
Interleukin 9 (IL-9) has pleiotropic functions in the immune system and signals through its specific IL-9 receptor (IL-9R) (Renauld et al.). IL-9/IL-9R signaling pathway mainly targets the downstream activation of JAK/STAT (janus kinase/signal transducer and activator of transcription) and subsequent phosphorylation cascades initiated by multiple kinases including IRS–PI3K–PKB (insulin receptor substrate, phosphatidyl-inositol 3-kinases, protein kinase-B) and ERK (Knoops and Renauld; Fontaine et al.). IL-9 has been shown to have a role in Th1/Th17-mediated inflammation and in regulatory T cell responses (Singh et al.; Goswami and Kaplan). IL-9/IL-9R signaling pathway represents a novel endogenous anti-apoptotic mechanism for cortical neurons (Fontaine et al.). IL-9 secreting T cells, termed Th9 cells, contribute to both effective immunity and immunopathological disease, and have been shown to have a role in the treatment of allergic and autoimmune disease (Kaplan et al.).
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Human recombinant BAFF (active) (soluble) (from E. coli)
Supplier: ProSci Inc.
BAFF is mainly produced by innate immune cells such as neutrophils, monocytes, macrophages, dendritic cells, follicular dendritic cells. T cells, activated B cells, some malignant B cells and also non-lymphoid cells like astrocytes, synoviocytes and epithelial cells can also produce BAFF. BAFF binds three distinct receptors (BAFF-R, TACI and BCMA) expressed predominantly on B cells, although activated T cells also express BAFF-R. BAFF is a master regulator of peripheral B cell survival, and together with IL-6, promotes Ig class-switching and plasma cell differentiation. Besides its major role in B cell biology, BAFF co-stimulates activated T cells. Deregulated expression of BAFF leads to autoimmune disorders in mice. In humans, elevated levels of soluble BAFF have been detected in the serum of patients with various autoimmune diseases such as Sjoegren syndrome, Rheumatoid arthritis (RA), Multiple sclerosis (MS) and Systemic Lupus Erythematosus (SLE). BAFF has also increased levels in some lymphoid cancers. Processed human BAFF can either remain as a trimer, which is usual for TNF family ligands or assemble into 60-mer composed of 20 trimers. Mouse BAFF 60-mer has been identified in the serum of BAFF transgenic mice. Oligomerisation of BAFF 3-mer into 60-mer in human BAFF is prevented by mutation of His218, a residue critical for 3-mer-to-3-mer interactions, but not for receptor binding. Despite the predominant functional role of processed BAFF in vivo, membrane-bound BAFF might also play a role. Indeed, soluble BAFF (3-mer) can trigger BAFF-R but not TACI or BCMA, whereas oligomeric forms of BAFF (BAFF 60-mer), which mimic membrane-bound BAFF, activate all BAFF receptors.
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Test Sieve 400/65 mm, mesh = 0.16 mm ISO 3310-1 1 * 1 items
Supplier: FRITSCH
Test Sieve 400/65 mm, mesh = 0.16 mm ISO 3310-1 1 * 1 items
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COLUMN ORB SAX 80Å 10µM 4.6M 1 * 1 items
Supplier: WATERS
COLUMN ORB SAX 80Å 10µM 4.6M 1 * 1 items
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Total Rat Embryo RNA 1 * 200 µG
Supplier: Ambion
Total Rat Embryo RNA 1 * 200 µG
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VWR® pHenomenal® MU 6100 L Multi-Parameter Meter (pH/Conductivity/DO), Bench
Supplier: VWR Collection
User friendly instrument, with articulated electrode stand and IP 43-rated housing, provides high resolution and accuracy for precise multi-parameter measurements. This meter can either measure pH/mV and conductivity or pH/mV and oxygen simultaneously. Complete with USB output for connection to a computer. GLP compliant.
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Pirani-Controller CVC 3000 Set with KF DN 16, for example for RE/RZ 2.5 and RE/RZ 6 with VSP 3000, Vacuum-Valve VV-B 15C, T-Connection, SW DN 15 and more connection parts 1 * 1 SET
Supplier: VACUUBRAND
Pirani-Controller CVC 3000 Set with KF DN 16, for example for RE/RZ 2.5 and RE/RZ 6 with VSP 3000, Vacuum-Valve VV-B 15C, T-Connection, SW DN 15 and more connection parts 1 * 1 SET
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CYCLOHEXIMIDE SOLUTION 10X10ML 1 * 100 mL
Supplier: Merck
CYCLOHEXIMIDE SOLUTION 10X10ML 1 * 100 mL
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TIP EJECTOR-PART 1 1 * 1 items
Supplier: Thermo Fisher Scientific
TIP EJECTOR-PART 1 1 * 1 items
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EZ PACKING SLEEVE 10MM 1 * 1 items
Supplier: OMNIFIT
EZ PACKING SLEEVE 10MM 1 * 1 items
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EZTEST STEAM G.STEAROTHERMOPHILUS 10.6 1 * 100 items
Supplier: MESA LABORATORIES
EZTEST STEAM G.STEAROTHERMOPHILUS 10.6 1 * 100 items
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Test kit Alkalische phosphatase dgkc 10x20+2x30ml 1 * 1 KIT
Supplier: DIAGNOSTIC SYSTEMS DIASYS
Test kit Alkalische phosphatase dgkc 10x20+2x30ml 1 * 1 KIT
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O-RING 2,6 X 1,3 EPDM 1 * 1 items
Supplier: Thermo Fisher Scientific
O-RING 2,6 X 1,3 EPDM 1 * 1 items
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Human Recombinant IL-1 beta, ACF
Supplier: STEMCELL Technologies
Interleukin 1 beta (IL-1β) is synthesised as an inactive precursor protein or pro-IL-1β. This precursor is cleaved intracellularly by Caspase 1 (IL-1β convertase) to form the active form of the protein that is later secreted (Allan et al.). IL-1β binds to IL-1 receptor and activates intracellular signaling via the MAPK or NF-kB pathway. IL-1β is released by monocytes, tissue macrophages, and dendritic cells in response to infection or injury and induces expression of acute-phase proteins. It also promotes the infiltration of inflammatory and immunocompetent cells from the circulation into the extravascular space and affected tissues, by stimulating the expression of adhesion molecules on endothelial cells. IL-1β also affects other immune cells; for example, it co-stimulates T cell functions together with antigen or mitogen. It also stimulates Th17 differentiation and B cell proliferation in an IL-6-dependent manner. This product is animal component-free.
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Human Recombinant bFGF
Supplier: STEMCELL Technologies
Basic fibroblast growth factor (bFGF) is a prototypic member of the fibroblast growth factor family. Cytokines in the FGF family possess broad mitogenic and cell survival activities (Folkman and Klagsbrun; Kimelman and Kirschner) and are involved in a variety of biological processes including cell proliferation, differentiation, survival, and apoptosis (Folkman and Klagsbrun; Klagsbrun; Rifkin and Moscatelli). bFGF has the β-trefoil structure (Ponting and Russell), binds to the four FGF receptor (FGFR) family members, and activates JAK/STAT, PI3K, ERK1/2, and other receptor tyrosine kinase (RTK) signaling pathways. It supports the maintenance of undifferentiated human embryonic stem cells (Xu et al.; Kang et al.), stimulates human embryonic stem cells to form neural rosettes (Zhang et al.), and improves proliferation of human mesenchymal stem cells and enhances chondrogenic differentiation (Solchaga et al.).
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HPL Flat Base, 800mm wide 1 * 1 items
Supplier: BIGNEAT
HPL Flat Base, 800mm wide 1 * 1 items
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Human Recombinant PDGF-AB
Supplier: STEMCELL Technologies
Platelet-derived growth factor (PDGF) is a dimeric glycoprotein consisting of two disulfide bridge-stabilized polypeptide chains, A and B, which are assembled as heterodimers (PDGF-AB) or homodimers (PDGF-AA and PDGF-BB) (Fretto et al.; Westermark and Heldin). PDGF signals through the receptor tyrosine kinases PDGFRalpha and PDGFRbeta. It has been shown that PDGF-induced migration involves signaling pathways involving MEK/ERK, EGFR, Src, and PI3K/AKT (Kim et al.). PDGF is a potent mitogen for cells of mesenchymal origin- like fibroblasts, glial cells, and vascular smooth muscle cells. PDGF has been implicated in pathogenesis of atherosclerosis, glomerulonephritis, cancer, and in the contraction of vascular smooth muscle cells of rat aortic tissues (Fretto et al.; Sachinidis et al.). It has been shown that PDGF-AB together with 5-Azacytidine (Catalog #72012), induces the conversion of mature bone and fat cells into tissue-regenerative multipotent stem cells (Chandrakanthan et al.).
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VIAL WITHOUT SNAPCAP 10ML 1 * 100 items
Supplier: Roth Carl
VIAL WITHOUT SNAPCAP 10ML 1 * 100 items
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Syringe 10Ul Rn 23Ga. 1 * 1 items
Supplier: Agilent
Syringe 10Ul Rn 23Ga. 1 * 1 items
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FLUORESCENT LAMP REPLACEMENT 1 * 1 items
Supplier: LABCONCO
FLUORESCENT LAMP REPLACEMENT 1 * 1 items
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Nitrile GL30cmTechniGlove TN1201W tacky Size S 1 * 1.000 items
Supplier: TECHNI GLOVE
Nitrile GL30cmTechniGlove TN1201W tacky Size S 1 * 1.000 items
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BRASS MASS 10G WITH CERTIFICATE 1 * 1 items
Supplier: ZWIEBEL
BRASS MASS 10G WITH CERTIFICATE 1 * 1 items
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PISTON 0,5-10UL 1 * 1 items
Supplier: EPPENDORF
PISTON 0,5-10UL 1 * 1 items
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HEIZBAND SILIKON SIS10 1.5M 150W 1 * 1 ST
Supplier: ISOPAD
HEIZBAND SILIKON SIS10 1.5M 150W 1 * 1 ST
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VACUUM PIPETTE GREEN 1 * 1 items
Supplier: DELTALAB
VACUUM PIPETTE GREEN 1 * 1 items
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AutoCollect™ Specimen Collection Cards
Supplier: Ahlstrom-Munksjö
Ahlstrom AutoCollect™ specimen collection cards for high-throughput environments work efficiently in both DBS punch and direct elution. They are designed for microvolume sampling, transport and storage of dried blood spot (DBS) at ambient temperature.
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Precision therm., straight stem, -5+100:0,2C, capillary tube specially coated inside, with non-wetting blue special liquid, upper part 350x11mm, lower part 100x7-8mm, null
Supplier: Amarell
Precision therm., straight stem, -5+100:0,2C, capillary tube specially coated inside, with non-wetting blue special liquid, upper part 350x11mm, lower part 100x7-8mm, null