Supplier: STEMCELL Technologies

Interleukin 2 (IL-2) is a monomeric cytokine that was originally identified as a T cell growth factor (Gaffen and Liu). It binds to heterotrimeric receptors consisting of CD25, CD122, and CD132. Upon binding, it activates JAK3-, STAT5-, and AKT-dependent signaling pathways, which results in cellular proliferation and survival (Ma et al.). The majority of IL-2 is secreted by activated CD4+ and CD8+ T cells, although B cells and dendritic cells were found to produce IL-2 in small amounts. IL-2 downregulates immune responses to prevent autoimmunity during thymic development, influences the development of CD4+CD25+ regulatory T cells, and affects development of follicular helper T cells. IL-2 also controls inflammation by inhibiting Th17 differentiation (Banchereau et al.). High IL-2 levels in serum are associated with progression of scleroderma, rheumatoid arthritis, and gastric and non-small cell lung cancer, though no known disease can be directly attributed to the lack or excess of IL-2 (Gaffen and Liu).

Supplier: VACUUBRAND

Pirani-Controller CVC 3000 Set with KF DN 16, for example for RE/RZ 2.5 and RE/RZ 6 with VSP 3000, Vacuum-Valve VV-B 15C, T-Connection, SW DN 15 and more connection parts 1 * 1 SET

Supplier: STEMCELL Technologies

Interleukin 1 beta (IL-1β) is synthesised as an inactive precursor protein or pro-IL-1β. This precursor is cleaved intracellularly by Caspase 1 (IL-1β convertase) to form the active form of the protein that is later secreted (Allan et al.). IL-1β binds to IL-1 receptor and activates intracellular signaling via the MAPK or NF-kB pathway. IL-1β is released by monocytes, tissue macrophages, and dendritic cells in response to infection or injury and induces expression of acute-phase proteins. It also promotes the infiltration of inflammatory and immunocompetent cells from the circulation into the extravascular space and affected tissues, by stimulating the expression of adhesion molecules on endothelial cells. IL-1β also affects other immune cells; for example, it co-stimulates T cell functions together with antigen or mitogen. It also stimulates Th17 differentiation and B cell proliferation in an IL-6-dependent manner. This product is animal component-free.

Supplier: STEMCELL Technologies

Basic fibroblast growth factor (bFGF) is a prototypic member of the fibroblast growth factor family. Cytokines in the FGF family possess broad mitogenic and cell survival activities (Folkman and Klagsbrun; Kimelman and Kirschner) and are involved in a variety of biological processes including cell proliferation, differentiation, survival, and apoptosis (Folkman and Klagsbrun; Klagsbrun; Rifkin and Moscatelli). bFGF has the β-trefoil structure (Ponting and Russell), binds to the four FGF receptor (FGFR) family members, and activates JAK/STAT, PI3K, ERK1/2, and other receptor tyrosine kinase (RTK) signaling pathways. It supports the maintenance of undifferentiated human embryonic stem cells (Xu et al.; Kang et al.), stimulates human embryonic stem cells to form neural rosettes (Zhang et al.), and improves proliferation of human mesenchymal stem cells and enhances chondrogenic differentiation (Solchaga et al.).

Supplier: BIGNEAT

HPL Flat Base, 800mm wide 1 * 1 items

Supplier: STEMCELL Technologies

Platelet-derived growth factor (PDGF) is a dimeric glycoprotein consisting of two disulfide bridge-stabilized polypeptide chains, A and B, which are assembled as heterodimers (PDGF-AB) or homodimers (PDGF-AA and PDGF-BB) (Fretto et al.; Westermark and Heldin). PDGF signals through the receptor tyrosine kinases PDGFRalpha and PDGFRbeta. It has been shown that PDGF-induced migration involves signaling pathways involving MEK/ERK, EGFR, Src, and PI3K/AKT (Kim et al.). PDGF is a potent mitogen for cells of mesenchymal origin- like fibroblasts, glial cells, and vascular smooth muscle cells. PDGF has been implicated in pathogenesis of atherosclerosis, glomerulonephritis, cancer, and in the contraction of vascular smooth muscle cells of rat aortic tissues (Fretto et al.; Sachinidis et al.). It has been shown that PDGF-AB together with 5-Azacytidine (Catalog #72012), induces the conversion of mature bone and fat cells into tissue-regenerative multipotent stem cells (Chandrakanthan et al.).

Supplier: TECHNI GLOVE

Nitrile GL30cmTechniGlove TN1201W tacky Size S 1 * 1.000 items

Supplier: ZWIEBEL

BRASS MASS 10G WITH CERTIFICATE 1 * 1 items

Supplier: EPPENDORF

PISTON 0,5-10UL 1 * 1 items

Supplier: ISOPAD

HEIZBAND SILIKON SIS10 1.5M 150W 1 * 1 ST

Supplier: DELTALAB

VACUUM PIPETTE GREEN 1 * 1 items

Supplier: SAMCO

General Purpose Transfer Pipettes, Large Bulb. Length 15,1 cm. Stem Diameter 6,1 mm. Overall Capacity 8,6 mL. Bulb Draw 4,7 mL. 21 drops per mL. 1 * 4.000 items

Supplier: Roth Carl

VIAL WITHOUT SNAPCAP 10ML 1 * 100 items

Supplier: LABCONCO

FLUORESCENT LAMP REPLACEMENT 1 * 1 items

Supplier: Agilent

Syringe 10Ul Rn 23Ga. 1 * 1 items

Supplier: SCHUELKE MAYR

MIKROZID AF WIPES JUMBO BOX (220PCS) 1 * 1 kg

Supplier: Roth Carl

MULTI-GUARD-FILTER-TIPS 0,5-10µl 1 * 960 items

Supplier: Abnova

Recombinant protein, mas1 (np_002368.1) recombinant protein without tag. 1 * 2 µG

Supplier: Corning

10µl Pre-Sterilized Hamilton CO-RE Style Liquid Level Sensing Filter Tip. 96 Tips per Rack, 5 Racks/pack, 12 packs/case 1 * 5.760 items

Supplier: LINKER INDUSTRIE TECHN

Reagenzglasgestell, Fachanzahl 4 x 12, Gestellhöhe 100 mm aus Edelstahl, rostfrei, elektrochemisch poliert mit 2 Facheinteilungen, Boden aus Schweißgitter w 8 mm Fachgröße 18 x 18 mm (bis Ø 16 mm) 1 * 1 ST

Supplier: Merck

EARLE#S BALANCED SALTS, 10×, WITHOUT SODIUM BICARBONATE, STERILE-FILTERED. CELL CULTURE TESTED 1 * 100 mL

Supplier: witeg Labortechnik

FLASK, ROUND BOTTOM, MEDIUM NECK, ACC TO DIN 12348, 10ML, ST 19/26, 41X75 MM 1 * 1 items

Supplier: VWR Collection

This user friendly portable instrument with robust IP 67 rated housing provides high resolution and accuracy for precise measurements of pH, mV, conductivity and oxygen in field applications (can only be used to measure any two of these at the same time). Complete with waterproof USB output for connection to a computer. GLP compliant.

Supplier: Restek

[EN]RXI-LAO COLUMN 40 MX0.18MM IDX1.0µM 1 * 1 ST

Supplier: Thermo Fisher Scientific

TIP EJECTOR-PART 1 1 * 1 items

Supplier: OMNIFIT

EZ PACKING SLEEVE 10MM 1 * 1 items

Supplier: Merck

CYCLOHEXIMIDE SOLUTION 10X10ML 1 * 100 mL

Supplier: HIRSCHMANN

Flask volumetric, capacity 20ml, glass stopper, class A, NS 12/21, amber graduation, conformity certified. 1 * 2 items

Supplier: Ahlstrom-Munksjö

Ahlstrom AutoCollect™ specimen collection cards for high-throughput environments work efficiently in both DBS punch and direct elution. They are designed for microvolume sampling, transport and storage of dried blood spot (DBS) at ambient temperature.

Supplier: CONTACTO

matt gebürstet, einseitig graduiert mit 1-l Skalierung, gebördelter Rand, Bodenreifen mit Ablauflöchern für Spülwasser, extra schwere Qualität 1 * 1 ST