106141 Results for: "Methyl-2-thiophenecarboxylate&pageNo=25"

Supplier: ProSci Inc.

Human CD137 (4-1BB) is a costimulatory molecule of the tumour necrosis factor (TNF) receptor superfamily. The glycoprotein 4-1BB is expressed mainly on activated CD4+ and CD8+ T cells and binds to a high-affinity ligand (4-1BBL) expressed on several antigen-presenting cells such as macrophages and activated B cells. Upon ligand binding, 4-1BB is associated with the tumour receptor-associated factors (TRAF), the adaptor protein and mediates downstream signalling events including the activation of NF-kappaB and cytokine production. 4-1BB signalling either by binding to 4-1BBL or by antibody ligation delivers signals for T cell activation and growth as well as monocyte proliferation and B cell survival, and plays a important role in the amplification of T cell-mediated immune responses. In contrast, it can also enhance activation-induced T cell apoptosis when triggered by engagement of the TCR/CD3 complex. In addition, the 4-1BB/4-1BBL costimulatory pathway has been shown to augment secondary CTL responses to several viruses and increase antitumour immunity. 4-1BB is therefore a promising candidate for immunotherapy of human cancer.

Supplier: Thermo Fisher Scientific

Use Thermo Scientific™ SureSTART™ 9 mm screw caps with screw vials that have a 9 mm opening, including SureSTART 2 ml glass screw vials, 2 ml gold-grade glass screw vials, total recovery glass screw microvials for <2 ml samples, 1,7 ml high recovery glass screw vials, and glass screw microvials for <2 ml samples (Level 3). Select Level 3 products for ultimate performance and sensitivity from methods, while maintaining the highest levels of sample security and integrity.

Supplier: Merck

BAY-6035

Supplier: Aesculap

NADELETUI, 50X 25X 5 MM, GELOCHT 1 * 1 ST

Supplier: Merck

Micro particles based on polystyrene, 250 mym 1 * 5 mL

Supplier: G-Biosciences

Irreversible inhibitor of serine proteases, including trypsin & chymotrypsin null

Supplier: LEICA MICROSYSTEMS

Educational stereo microscope for beginners in college and university Leica EZ4.

Supplier: ProSci Inc.

Neutrophil gelatinase-associated lipocalin(LCN2) is a secreted protein and belongs to the calycin superfamily. This protein is released from injured tubular cells after various damaging stimuli, is already known by nephrologists as one of the most promising biomarkers of incoming Acute Kidney Injury (AKI). Recent evidence also suggests its role as a biomarker in a variety of other renal and non-renal conditions. Moreover, recent studies seem to suggest a potential involvement of this factor also in the genesis and progression of chronic kidney diseases. NGAL is the first known mammalian protein which specifically binds organic molecules called siderophores, which are high-affinity iron chelators. NGAL, first known as an antibacterial factor of natural immunity, and an acute phase protein, is currently one of the most interesting and enigmatic proteins involved in the process of tumor development. acting as an intracellular iron carrier and protecting MMP9 from proteolytic degradation, NGAL has a clear pro-tumoral effect, as has already been observed in different tumors (e.g. breast, stomach, oesophagus, brain) in humans. In thyroid carcinomas, NGAL is strongly induced by NF-kB, an important factor involved both in tumor growth and in the link between chronic inflammation and neoplastic development. Thus, Lipocalin-2 (LCN2/NGAL) has been implicated in a variety of processes including cell differentiation, proliferation, survival and morphogenesis.

Supplier: Heidolph Instruments GmbH & Co.KG

Laboratory screw connection GL25 - diam10sw 1 * 1 items

Supplier: Merck

PIPES monosodium salt, Sigma-Aldrich®

Supplier: Molekula

Chromotropic acid disodium salt dihydrate

Supplier: ProSci Inc.

RAC-alpha serine/threonine-protein kinase (AKT1) is also known PKB, Protein kinase B alpha, PKB alpha, Proto-oncogene c-Akt and RAC-PK-alpha, which belongs to the protein kinase superfamily, AGC Ser/Thr protein kinase family and RAC subfamily and is expressed in prostate cancer and levels increase from the normal to the malignant state (at protein level). AKT1 is one of 3 closely related serine/threonine-protein kinases (AKT1, AKT2 and AKT3) called the AKT kinase, and which regulate many processes including metabolism, proliferation, cell survival, growth and angiogenesis. AKT is responsible of the regulation of glucose uptake by mediating insulin-induced translocation of the SLC2A4/GLUT4 glucose transporter to the cell surface. AKT regulates also the storage of glucose in the form of glycogen by phosphorylating GSK3A at 'Ser-21' and GSK3B at 'Ser-9', resulting in inhibition of its kinase activity. Phosphorylation of GSK3 isoforms by AKT is also thought to be one mechanism by which cell proliferation is driven. AKT regulates also cell survival via the phosphorylation of MAP3K5 (apoptosis signal-related kinase).

Supplier: Spectrum Chemical

Thiamine Hydrochloride, FCC is the hydrochloride salt of vitamin B1 and used to treat or prevent vitamin B1 deficiency. The FCC grade meets the requirements of the Food Chemical Codex indicates and is suitable for all food, beverage and nutritional supplement applications. Spectrum Chemical offers over 300 Food grade chemical ingredients packaged in laboratory size bottles to production drum quantities and are manufactured, packaged and stored under current Good Manufacturing Practices (cGMP) per 21CFR part 211 in FDA registered and inspected facilities.

Supplier: PanReac AppliChem

RNase-ExitusPlus™ is a non-alkaline, non-corrosive and non-carcinogenic cleansing solution that is highly active against RNase contamination. RNase-ExitusPlus™ has been demonstrated to inactivate more than 20 μg of RNase A dried onto the bottom of a microcentrifuge tube. RNase-ExitusPlus™ is stable for approximately 18 months and heat resistant. It should be stored at room temperature; at colder temperatures a precipitate may form which is easily brought into solution at 37 °C. RNase-ExitusPlus™ is supplied in spray bottles and a one litre refill pack is also available.

Supplier: Biotium

Dihydrorhodamine 123 is the reduced form of rhodamine 123, which is a commonly used fluorescent mitochondrial dye. It is non-fluorescent, but it readily enters most of the cells and is oxidized by oxidative species or by cellular redox systems to the fluorescent rhodamine 123 that accumulates in mitochondrial membranes. It is useful for detecting reactive oxygen species including superoxide (in the presence of peroxidase or cytochrome c) and peroxynitrite. Dihydrorhodamine 123 dihydrochloride is functionally equivalent to dihydrorhodamine 123 but with increased stability toward air oxidation and light during storage. Dihydroethidium (also called hydroethidium) is the chemically reduced form of the commonly used DNA dye ethidium bromide. The probe is useful to detect oxidative activities in viable cells, including respiratory burst in phagocytes. Dihydroethidium itself has blue fluorescence (355/420 nm) in cells, while the oxidized form ethidium has red fluorescence (518/605 nm) upon DNA intercalation. H2DCFDA (2′,7′-Dichlorodihydrofluorescein diacetate) is a useful fluorogenic reagent to detect reactive oxygen intermediates in cells. On oxidation, H2DCFDA becomes the highly green fluorescent 2′,7′-dichlorofluorescein, 504/529 nm (end product).

Supplier: MICRONOVA

A range of lightweight, snap-on flat head mop covers with urethane foam interiors, designed for effective cleaning and sanitising in the cleanroom. A variety of fabric options provide excellent absorbency, effective cleaning, and disinfectant dispersal for specialised cleaning.

Supplier: Aesculap

RASPATORIUM, LAMBOTTE, 25,0MM BR., 215MM 1 * 1 ST

Supplier: DEXTRA LABORATORIES

L-FUCOSE

Supplier: RIXIUS

SQUARE BOTTLE HDPE NATURAL GW 40, 250 1 * 2.160 items

Supplier: MACHEREY-NAGEL

Sample beaker 25ml VISOCOLOR. 1 * 1 items

Supplier: MP Biomedicals

Medium Fractionation Range (MW)Globular proteins: 1000-5000 Dextrans:100-5000Dry Bead Diameter: 50-150 µmBed Volume: 4-6 ml/g 1 * 10 g

Supplier: ZARGES LEICHTBAU

ENDKAPPE BLACK TO HOLM 58X25MM 1 * 1 items

Supplier: EPPENDORF

NOSE CONE INC. SEAL 0.1-2.5UL 1 * 1 items

Supplier: GLASWARENFABRIK KARL HECHT

without graduation 1 * 1 items

Supplier: WATERS

XBRIDGE BEH C18 XP COLUMN, 130Å, 2.5µM, 1 * 3 items

Supplier: Abnova

Mgcl 25mm can be used for optimization of magnesium ion concentration in pcr reaction. 1 * 1 KIT

Supplier: NEW ENGLAND BIOLABS

T7 RNA Polymeras

Supplier: REAGECON

Reagecon 251.3 mS/cm Conductivity Standard at 25C 1 * 500 mL

Supplier: Thermo Fisher Scientific

SURESTART 384 well plate, square, v base, 252ul, pp, 1 * 5 items

Supplier: Pharmablock (USA)