69205 Results for: "FRISTADS+KANSAS&pageNo=50&view=easy"

Supplier: STEMCELL Technologies

Interferon gamma-inducible protein (IP) 10 or CXCL10 is a member of the CXC chemokine family. It binds CXCR3 activating ERK1/2, p38/MAPK, JNK, and PI3-kinase/AKT signaling pathways, inducing intracellular calcium influx, DNA synthesis, cell proliferation, and chemotaxis. IP-10 regulates innate and adaptive immune responses by affecting the function of activated T cells, natural killer cells, inflammatory dendritic cells, macrophages, and B cells. IP-10 is produced by leukocytes, activated neutrophils, eosinophils, monocytes, epithelial cells, endothelial cells, fibroblasts, and keratinocytes in response to IFN-gamma. IP-10 has been implicated in a wide range of diseases, including infectious diseases and chronic inflammatory and autoimmune diseases, as well as in tumor formation (Liu et al.).

Supplier: STEMCELL Technologies

Epidermal growth factor receptor (EGFR) is a type I transmembrane protein and receptor tyrosine kinase. EGFR has been shown to bind to some members of the EGF family ligands including EGF, amphiregulin, TGF-α, betacellulin, epiregulin, heparin-binding EGF, and neuregulin-2α. EGFR ligand binding induces homodimerization, as well as heterodimerization of EGFR with ErbB2 or with ligand-activated ErbB3 or ErbB4 (Schlessinger). Dimerization results in kinase activation, phosphorylation, and cell signaling, mediated primarily through MEK/ERF and AKT pathways (Navlonic et al.). EGFR signaling has been shown to regulate cell proliferation, differentiation, motility, and apoptosis. Elevated levels of EGFR have been correlated with carcinogenesis (Maihle et al.). Protein contains a His-residue tag at the carboxyl end of the polypeptide chain.

Supplier: HIRSCHMANN

Spare piston for akku-drive 50ml 1 * 1 items

Supplier: STEMCELL Technologies

Fibroblast growth factor 7 (FGF-7) is a member of the FGF family, and acts exclusively through a subset of FGF receptor isoforms expressed predominantly by epithelial cells (Finch and Rubin). FGF-7 seems to act specifically on epithelial cells and stimulates proliferation, migration, and differentiation of these cells, and also participates in epithelial protection and repair both in vitro and in vivo (Finch and Rubin; Werner). In contrast, FGF-7 is produced solely by cells of mesenchymal origin, and functions as a paracrine mediator of mesenchymal-epithelial communication (Rubin et al.). FGF-7 has also been shown to supplement several wound-healing properties of bioengineered skin (Erdag et al.) and to induce autophagy in human keratinocytes (Belleudi et al.). Additionally, FGF-7 has a role in pluripotent stem cell differentiation to endodermal pancreatic-like insulin-producing cells and thymic epithelial cells (Inami et al.; Niu et al.).

Supplier: STEMCELL Technologies

Interleukin 10 (IL-10) is the founding member of the IL-10 family of class II cytokines. All of the IL-10 cytokine family members have a four-helix bundle consisting of α-helical folds. Upon binding to its receptor, IL-10 activates signaling through JAK1 and STAT3. It is produced by dendritic cells, macrophages, and CD4+ T cells, as well as mast cells, NK cells, neutrophils, and B cells, under specific stimulating conditions (Saraiva and O'Garra). IL-10 can inhibit the expression of pro-inflammatory cytokines and promote healing processes, and is important for the function of regulatory T cells. IL-10 also enhances B cell proliferation, immunoglobulin secretion, and class II MHC expression, while IL-10 produced by macrophages inhibits activation of neighboring macrophages, thus allowing a level of self-regulation (Ouyang et al.).

Supplier: witeg Labortechnik

FLASK 50ML CLAISENUPPSATS 1 * 1 items

Supplier: HOFMANN GLASTECHNIK

Flansch, braun graduiert, Marke bei 10/20/30/40 + 45 ltr. 1 * 1 ST

Supplier: MORGAN ADVANCED MATERIALS HALD

ALSINTTUBE 60X50X1000MM 1 * 1 items

Supplier: Amarell

Thermometer similar to IP 44 C, solid stem, white backed, 15+121:0,5°C, red special liquid, durable pigment, suitable for government calibration 1 * 1 items

Supplier: Amarell

Precision therm., straight stem, -5+100:0,2C, capillary tube specially coated inside, with non-wetting blue special liquid, upper part 350x11mm, lower part 100x7-8mm, null

Supplier: Socorex Isba

SOC VERNIER 50ÁL 1 * 1 items

Supplier: LAMAPLAST

BIN 50L GREEN 1 * 1 items

Supplier: Thermo Fisher Scientific

L-Arginine hydrochloride for SILAC

Supplier: ProSci Inc.

Mouse Interleukin 36 beta (IL-36B)is a member of the IL-1 family of proteins. It is a cytokine that binds to and signals through the IL1RL2/IL-36R receptor which in turn activates NF-kappa-B and MAPK signalling pathways in target cells linked to a pro-inflammatory response. IL-36B is synthesised in several cells including resting and activated monocytes, and B cells. The receptor for IL-36 beta is thought to be a combination of IL-1 Rrp2 and IL-1 RAcP. Interleukin 36 beta is one part of the IL-36 signalling system that is thought to be present in epithelial barriers and to take part in local inflammatory response; similar to the IL-1 system with which it shares the coreceptor IL1RAP. Interleukin 36 beta are involved in a number of fundamental biological processes such as stimulating production of interleukin-6 and interleukin-8 in synovial fibrobasts, articular chondrocytes and mature adipocytes, inducing expression of a number of antimicrobial peptides including beta-defensin 4 and beta-defensin 103 as well as a number of matrix metalloproteases , inducing the production of proinflammatory cytokines in bone marrow-derived dendritic cells (BMDCs), including IL-12, Il-1 beta, IL-6, TNF-alpha and IL-23, and activating p38 MAPK phosphorylation in BMDCs.Moreover, interleukin 36 beta may be involved in skin inflammatory response by acting on keratinocytes, dendritic cells, and indirectly on T cells to drive tissue infiltration, cell maturation and cell proliferation. It plays an important role in dendritic cell maturation by stimulating the surface expression of CD80, CD86 and MHC class II and inducing the production of IFN-gamma, IL-4 and IL-17 by T helper 1 (Th1) cells, cultured CD4+ T cells and splenocytes.

Supplier: ProSci Inc.

Interleukin-15 receptor subunit alpha, also known as Il15ra, is a high-affinity receptor for interleukin-15. Il15ra associates as a heterotrimer with the IL-2 receptor beta and gamma subunits (Common gamma chain, or gamma c) to initiate signal transduction. It can signal both in cis and trans where IL15R from one subset of cells presents IL15 to neighboring IL2RG-expressing cells. Il15ra is expressed in special cells including a wide variety of Tand B cells and non-lymphoid cells. Human Il15ra shares 45% amino acid sequence homology with the mouse form of the receptor. Eight isoforms of IL-15 R alpha mRNA have been identified, resulting from alternative splicing events involving different exons.Interleukin 15 (IL-15) is a cytokine that regulates T cell and natural killer cell activation and proliferation. IL-15 binds to the alpha subunit of the IL15 receptor (IL-15RA) with high affinity. IL-15 also binds to the beta and gamma chains of the IL-2 receptor, but not the alpha subunit of the IL2 receptor. IL-15 is structurally and functionally related to IL-2. Both cytokines share some subunits of receptors, allowing them to compete for and negatively regulate each other's activity. The number of CD8+ memory T cells is controlled by a balance between IL-15 and IL-2. Despite their many overlapping functional properties, IL-2 and IL-15 are, in fact, quite distinct players in the immune system. IL-15 is constitutively expressed by a wide variety of cell types and tissues, including monocytes, macrophages and DCs.

Supplier: MACHEREY-NAGEL

Receiver Plates 50µm hydrophilized (4) 1 * 1 KIT

Supplier: NICKEL ELECTRO

PLATINUM CRUCIBLE 50ML 1 * 1 items

Supplier: IKA

SHAFT FOR IKA S50N 1 * 1 items

Supplier: VACUUBRAND

Pirani-Controller CVC 3000 Set with KF DN 16, for example for RE/RZ 2.5 and RE/RZ 6 with VSP 3000, Vacuum-Valve VV-B 15C, T-Connection, SW DN 15 and more connection parts 1 * 1 SET

Supplier: CHRIST MARTIN

[EN]BASIC PACKAGE RVC 2-33 IR 1 * 1 ST

Supplier: VWR Collection

This user friendly portable instrument with robust IP 67 rated housing provides high resolution and accuracy for precise measurements of pH, mV, conductivity and oxygen in field applications (can only be used to measure any two of these at the same time). Complete with waterproof USB output for connection to a computer. GLP compliant.

Supplier: KLEINFELD

ELECTRIC HEATING JACKETT TYPE EM D 1 * 1 items

Supplier: QVF LABORTECHNIK

SOLVENT FLOW APPARATUS W/ 500ML VESSEL 1 * 1 items

Supplier: Palintest

Starter Pack Calcium Hardness 1 * 1 Each

Supplier: FRITSCH

Sample divider laborette 27, without dividing head, 115 V 1 * 1 items

Supplier: Merck

4-Nitrophenyl phosphate disodium salt hexahydrate has been used in enzyme-linked immunosorbent assay (ELISA) as a substrate for streptavidin-Alkaline Phosphatase. It has also been used as a substrate in control assay for comparing 4-aminophenyl phosphate/diethanolamine (APP/DEA) assay for alkaline phosphatase.

Supplier: QUARTZTECHNISCHE WERKSTATTEN

PISTON 50ML ERLENMEYER QUARTZGLASS 1 * 1 items

Supplier: TRESTON

DIVIDER D-10 4010/5010 1 * 1 items

Supplier: LAMAPLAST

BIN 50L YELLOW 1 * 1 items

Supplier: LAMAPLAST

BIN 50L BLUE 1 * 1 items