10431 Results for: "Ethyl-4-Hydroxy-1-piperidinecarboxylate&pageNo=21"

Supplier: Tonbo Biosciences

The MOPC-21 immunoglobulin is useful as an isotype-matched control. The MOPC-21 immunolglobulin has an unknown binding specificity and is used as an isotype control for mouse IgG1 antibodies.

Supplier: AAT BIOQUEST

QXY21 is the same molecule to QSY-21 acid (ThermoFisher).

Supplier: Abcam

Rabbit monoclonal [E121-21] to STAT3.

Supplier: Abcam

Mouse monoclonal [N22/21] to SHANK1.

Supplier: STEMCELL Technologies

Fibroblast growth factor 21 (FGF-21) is a member of the FGF family. Using β-Klotho as a cofactor, FGF-21 signals through FGF receptor 1c and 4 to activate PI3K and MAPK pathways (Mattila and Härkönen; Kharitonenkov et al.). FGF-21 expression is regulated by tissue-specific peroxisome proliferator-activated receptors (PPARs). Upon PPAR-α stimulation FGF-21 is produced in the liver, and activation of PPAR-γ leads to FGF-21 production in adipose tissue. FGF-21 promotes insulin-independent glucose uptake and lipid accumulation in primary human adipocytes and in mouse 3T3-L1 cells. In pancreatic islets and INS-1 cells it inhibits glucose-mediated glucagon release and stimulates insulin production. FGF-21 does not induce proliferation in immortalized cell lines, unlike other FGFs (Kharitonenkov and Shanafelt). FGF-21 regulates thermogenesis in white and brown adipose tissue, and metabolic processes in cells of pancreatic origin (Kharitonenkov et al.).

Supplier: Abcam

Mouse IL-21 ELISA Kit

Supplier: Shenandoah Biotechnology

Interleukin 21 (IL-21) is a member of the common-gamma chain family of cytokines that are involved in immunoregulation. IL-21 is normally expressed by activated CD4+ T cells. The IL-21 receptor (IL-21R) activates the JAK/STAT signaling pathway and is expressed on T, B, and natural killer (NK) cells. Within the B cell lineage, IL-21 is a switch factor regulating IgG1 and IgG3 antibody production. IL-21 also cooperates with interleukin 4 (IL-4) for the production of multiple antibody classes in B cells. IL-21 has pleiotropic effects on the proliferation, differentiation, and effector functions of B, T, NK, and dendritic cells.

Supplier: ProSci Inc.

IL-21 receptor peptide is used for blocking the activity of IL-21 receptor antibody.

Supplier: STEMCELL Technologies

Interleukin 21 (IL-21) is a pleiotropic cytokine that is composed of four α-helical bundles and primarily produced by natural killer T (NKT) cells, T follicular helper (Tfh) cells, and Th17 cells (Spolski and Leonard 2008). IL-21 signals via heterodimers of the IL-21 receptor (IL-21R) and the IL2RG encoded common cytokine receptor γ-chain (Parrish-Novak et al.; Ozaki K et al. 2000), and utilizes the JAK/STAT, MAPK, and PI3K pathways (Spolski and Leonard 2014). IL-21 has been shown to have a critical role in regulating immunoglobulin production and differentiation of the pro-inflammatory Th17 population of cells (Ozaki et al. 2002; Nurieva et al.). Additionally, IL-21 specifically sustains CD8+ T cell effector activity and provides a mechanism of CD4+ T cell help during chronic viral infection (Elsaesser et al.). IL-21 signaling was also found critical for the development of type 1 diabetes in NOD mice (Sutherland et al.) and control of T cell autoimmunity by regulatory B cells (Yoshizaki et al.).

Supplier: Biorbyt

Mouse FGF-21 ELISA kit is designed for the quantification of mouse fibroblast growth factor 21 (FGF-21) in serum, plasma and cell culture supernate samples.

Supplier: US Biological

Anti-FGF-21 Rat Monoclonal Antibody [clone: FG224-7]

Supplier: US Biological

Anti-Cytochrome C Releasing Factor 21 Sheep Polyclonal Antibody

Supplier: Biorbyt

Human FGF-21 ELISA Kit for the quantitative detection of human Fibroblast growth factor 21 (FGF-21) in cell culture supernates, serum and plasma (heparin, EDTA).

Supplier: US Biological

Anti-ABCC5 Rat Monoclonal Antibody [clone: M6II-21]

Supplier: US Biological

Anti-G Protein Coupled Receptor 21 Rabbit Polyclonal Antibody

Supplier: US Biological

Anti-FIBROBLAST GROWTH FACTOR-21 Rabbit Polyclonal Antibody

Supplier: US Biological

Anti-FGF-21 Mouse Monoclonal Antibody [clone: FG348-1]

Supplier: US Biological

Anti-ABCC3 Mouse Monoclonal Antibody [clone: M3II-21]

Supplier: US Biological

Anti-FGF-21 Mouse Monoclonal Antibody [clone: FG204-3]

Supplier: ENZO LIFE SCIENCES

Anti-IgG1 Mouse Monoclonal Antibody [clone: MOPC-21]

Supplier: ENZO LIFE SCIENCES

Anti-IgG1 Mouse Monoclonal Antibody [clone: MOPC-21]

Supplier: US Biological

Anti-G Protein Coupled Receptor 21 Rabbit Polyclonal Antibody

Supplier: US Biological

Anti-Heat Shock Protein 21 Rabbit Polyclonal Antibody

Supplier: STEMCELL Technologies

Interleukin 21 (IL-21) is a pleiotropic cytokine that is composed of four α-helical bundles and primarily produced by natural killer T (NKT) cells, T follicular helper (Tfh) cells, and Th17 cells (Spolski and Leonard 2008). IL-21 signals via receptor heterodimerization of IL-21 receptor and IL-2 receptor subunit gamma (IL-2RG or CD132), both of which have a common gamma-chain subunit and activate the JAK/STAT, MAPK, and PI3K pathways (Parrish-Novak et al.; Ozaki et al. 2000; Spolski and Leonard 2014). IL-21 has been shown to have a critical role in regulating immunoglobulin production and differentiation of the pro-inflammatory Th17 population of cells (Ozaki et al. 2002; Nurieva et al.). Additionally, IL-21 specifically sustains CD8+ T cell effector activity and provides a mechanism of CD4+ T cell help during chronic viral infection (Elsaesser et al.). IL-21 signaling was also found critical for the development of type 1 diabetes in non-obese diabetic (NOD) mice (Sutherland et al.) and control of T cell autoimmunity by regulatory B cells (Yoshizaki et al.).

Supplier: US Biological

Anti-BNP Mouse Monoclonal Antibody [clone: 21-46]

Supplier: Abcam

Mouse monoclonal [BXP-21] to BCRP/ABCG2.

Supplier: Abcam

Mouse monoclonal [SP-DE4-21] to Substance P.

Supplier: Tonbo Biosciences

The MOPC-21 immunoglobulin is useful as an isotype-matched control. The MOPC-21 immunolglobulin has an unknown binding specificity and is used as an isotype control for mouse IgG1 antibodies.

Supplier: ANTIBODIES.COM

Rat IL-21 ELISA kit is a sandwich Enzyme-Linked Immunosorbent Assay (sELISA) designed for the in vitro quantitative determination of rat IL-21 in serum, plasma, tissue homogenates, and other biological fluids.

Supplier: Tonbo Biosciences

The MOPC-21 immunoglobulin is useful as an isotype-matched control. The MOPC-21 immunolglobulin has an unknown binding specificity and is used as an isotype control for mouse IgG1 antibodies.