22614 Results for: "Difluoromethanesulphonyl+chloride&pageNo=11&view=list"

Supplier: Bioss

Tumor suppressor serine/threonine-protein kinase that controls the activity of AMP-activated protein kinase (AMPK) family members, thereby playing a role in various processes such as cell metabolism, cell polarity, apoptosis and DNA damage response. Acts by phosphorylating the T-loop of AMPK family proteins, thus promoting their activity: phosphorylates PRKAA1, PRKAA2, BRSK1, BRSK2, MARK1, MARK2, MARK3, MARK4, NUAK1, NUAK2, SIK1, SIK2, SIK3 and SNRK but not MELK. Also phosphorylates non-AMPK family proteins such as STRADA, PTEN and possibly p53/TP53. Acts as a key upstream regulator of AMPK by mediating phosphorylation and activation of AMPK catalytic subunits PRKAA1 and PRKAA2 and thereby regulates processes including: inhibition of signaling pathways that promote cell growth and proliferation when energy levels are low, glucose homeostasis in liver, activation of autophagy when cells undergo nutrient deprivation, and B-cell differentiation in the germinal center in response to DNA damage. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton. Required for cortical neuron polarization by mediating phosphorylation and activation of BRSK1 and BRSK2, leading to axon initiation and specification. Involved in DNA damage response: interacts with p53/TP53 and recruited to the CDKN1A/WAF1 promoter to participate in transcription activation. Able to phosphorylate p53/TP53; the relevance of such result in vivo is however unclear and phosphorylation may be indirect and mediated by downstream STK11/LKB1 kinase NUAK1. Also acts as a mediator of p53/TP53-dependent apoptosis via interaction with p53/TP53: translocates to the mitochondrion during apoptosis and regulates p53/TP53-dependent apoptosis pathways. In vein endothelial cells, inhibits PI3K/Akt signaling activity and thus induces apoptosis in response to the oxidant peroxynitrite (in vitro). Regulates UV radiation-induced DNA damage response mediated by CDKN1A.

Supplier: Bioss

Tumor suppressor serine/threonine-protein kinase that controls the activity of AMP-activated protein kinase (AMPK) family members, thereby playing a role in various processes such as cell metabolism, cell polarity, apoptosis and DNA damage response. Acts by phosphorylating the T-loop of AMPK family proteins, thus promoting their activity: phosphorylates PRKAA1, PRKAA2, BRSK1, BRSK2, MARK1, MARK2, MARK3, MARK4, NUAK1, NUAK2, SIK1, SIK2, SIK3 and SNRK but not MELK. Also phosphorylates non-AMPK family proteins such as STRADA, PTEN and possibly p53/TP53. Acts as a key upstream regulator of AMPK by mediating phosphorylation and activation of AMPK catalytic subunits PRKAA1 and PRKAA2 and thereby regulates processes including: inhibition of signaling pathways that promote cell growth and proliferation when energy levels are low, glucose homeostasis in liver, activation of autophagy when cells undergo nutrient deprivation, and B-cell differentiation in the germinal center in response to DNA damage. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton. Required for cortical neuron polarization by mediating phosphorylation and activation of BRSK1 and BRSK2, leading to axon initiation and specification. Involved in DNA damage response: interacts with p53/TP53 and recruited to the CDKN1A/WAF1 promoter to participate in transcription activation. Able to phosphorylate p53/TP53; the relevance of such result in vivo is however unclear and phosphorylation may be indirect and mediated by downstream STK11/LKB1 kinase NUAK1. Also acts as a mediator of p53/TP53-dependent apoptosis via interaction with p53/TP53: translocates to the mitochondrion during apoptosis and regulates p53/TP53-dependent apoptosis pathways. In vein endothelial cells, inhibits PI3K/Akt signaling activity and thus induces apoptosis in response to the oxidant peroxynitrite (in vitro). Regulates UV radiation-induced DNA damage response mediated by CDKN1A.

Supplier: Basan

SUP.DESINF.PLAST.40X11CM SANS ARTICULATI 1 * 1 items

Supplier: MACHEREY-NAGEL

Filter paper circles MN 611 11cm diameter, pack of 100. 1 * 100 items

Supplier: MACHEREY-NAGEL

Filter paper circles MN 918 11cm diameter, pack of 100. 1 * 100 items

Supplier: MACHEREY-NAGEL

RS 232 connection cable 9-pin., female/female, crossed, (2-3/3-2) PC connection of NANOCOLOR 500 D, 400 D, 350 D, 300 D, 250 D, PF-1 1, PF-10, Lumi 10 and NANOCOLOR heating blocks 1 * 1 items

Supplier: Sartorius

Tubing for pressure-sided connection to the microsart e.jet transfer pump the required length depends on the distance between transfer pump and drain. length: 10 m. 1 * 1 items

Supplier: MACHEREY-NAGEL

Filter paper circles MN 960 11cm diameter, pack of 100. 1 * 100 items

Supplier: MACHEREY-NAGEL

Filter paper circles MN 875 11cm diameter, pack of 100. 1 * 100 items

Supplier: MACHEREY-NAGEL

Filter paper circles MN 605 11cm diameter, pack of 100. 1 * 100 items

Supplier: Merck

MONOCLONAL ANTI-HUMAN IGM (M-CHAIN SPECIFIC), ANTIBODY PRODUCED IN MOUSE 1 * 0,5 mL

Supplier: HUBER

connecting cable bracket board RS232 1 * 1 items

Supplier: MACHEREY-NAGEL

Filter paper circles MN 621 11cm diameter, pack of 100. 1 * 100 items

Supplier: MACHEREY-NAGEL

Filter paper circles MN 625 11cm diameter, pack of 100. 1 * 100 items

Supplier: Bioss

Tumor suppressor serine/threonine-protein kinase that controls the activity of AMP-activated protein kinase (AMPK) family members, thereby playing a role in various processes such as cell metabolism, cell polarity, apoptosis and DNA damage response. Acts by phosphorylating the T-loop of AMPK family proteins, thus promoting their activity: phosphorylates PRKAA1, PRKAA2, BRSK1, BRSK2, MARK1, MARK2, MARK3, MARK4, NUAK1, NUAK2, SIK1, SIK2, SIK3 and SNRK but not MELK. Also phosphorylates non-AMPK family proteins such as STRADA, PTEN and possibly p53/TP53. Acts as a key upstream regulator of AMPK by mediating phosphorylation and activation of AMPK catalytic subunits PRKAA1 and PRKAA2 and thereby regulates processes including: inhibition of signaling pathways that promote cell growth and proliferation when energy levels are low, glucose homeostasis in liver, activation of autophagy when cells undergo nutrient deprivation, and B-cell differentiation in the germinal center in response to DNA damage. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton. Required for cortical neuron polarization by mediating phosphorylation and activation of BRSK1 and BRSK2, leading to axon initiation and specification. Involved in DNA damage response: interacts with p53/TP53 and recruited to the CDKN1A/WAF1 promoter to participate in transcription activation. Able to phosphorylate p53/TP53; the relevance of such result in vivo is however unclear and phosphorylation may be indirect and mediated by downstream STK11/LKB1 kinase NUAK1. Also acts as a mediator of p53/TP53-dependent apoptosis via interaction with p53/TP53: translocates to the mitochondrion during apoptosis and regulates p53/TP53-dependent apoptosis pathways. In vein endothelial cells, inhibits PI3K/Akt signaling activity and thus induces apoptosis in response to the oxidant peroxynitrite (in vitro). Regulates UV radiation-induced DNA damage response mediated by CDKN1A.

Supplier: Avantor

Solve U/HPLC method development challenges systematically and efficiently using Avantor® ACE® columns and ChromSword 5.1 Lite method development software. The Avantor® ACE® ChromSword Method Development Kit includes six alternative selectivity Avantor® ACE® phases, a copy of ChromSword 5.1 Lite offline with a six month activation licence and a lot of technical information and support.

Supplier: FELDTMANN HELMUT

ORANGE SCHWARZ Norm: EN 388, EN 511 Träger: 100% Polyacryl, orange Beschichtung: Latexschaum, gesandet, schwarz - Premium-Qualität - Mittelstrick, nahtlos/ 10 G - mit Schlingenplüsch innen - Kälteschutz bis max. -30°C - Handrücken unbeschichtet - ges 1 * 60 PAAR

Supplier: Merck

MONOCLONAL ANTI-VEGF-RECEPTOR 1 (FLT-1) (CLONE FLT- 1 * 0,2 mL

Supplier: MORGAN ADVANCED MATERIALS HALD

CRUCIBLES MEDIUM FORM DIA 60MM NUMB 1 * 1 items

Supplier: Basan

LABEL75X45MM TABLE BACKGROUND WHITE 1 * 1 Roll

Supplier: Roth Carl

PIPETTENSPITZEN-MAKRO 1-5ML 250ST 1 * 250 ST

Supplier: HAMMACHER KARL

HSO 130-00 STUDENT CUTLERY 1 * 1 SET

Supplier: FELDTMANN HELMUT

WEISS Norm: EN 388 Träger: 60% Baumwolle/40% Polyester, weiß Beschichtung: Vinyl-Noppen, schwarz - Profi-Qualität - Grobstrick, nahtlos/ 7G - schwarze Grip-Noppen auf der Innenhandfläche und dem Handrücken - sehr gute Passform und sicherer Griff - at 1 * 240 PAAR

Supplier: IKA

Extremely powerful laboratory stirrers for highly viscous applications and intensive mixing of quantities up to 100 L (H₂O). Units automatically adjust the speed through microprocessor controlled technology within the speed range of speed range of 6 to 2000 min⁻¹ or 4 to 530 min⁻¹ (P4 models), all models have two speed ranges. Safety circuits ensure automatic cut off in anti-stall or overload conditions. The actual shaft speed and preset speed are constantly monitored and variations are adjusted automatically. This guarantees a constant speed even with changes in sample viscosities.

Supplier: Portwest

A highly innovative and functional jacket that provides seven wearer combinations. This extremely versatile jacket is highly adaptable to all weather conditions and is certified to the highest in waterproof and breathable standards.

Supplier: Portwest

The DX4 work trouser is ergonomically designed and uses the targeted placement of dynamic 4X stretch fabrics to give maximum range of movement when working. Triple stitching throughout for maximum durability.

Supplier: HONEYWELL SAFETY

Miller kernmantel edge forked shock absorbing lanyard 1,5 meters with twist lock karabiner and 2 GO55 1 * 1 items

Supplier: VELP SCIENTIFIC

The VELP RESPIROMETRIC sensor is designed to provide a smart, cloud-enabled solution to laboratories to perform multiple aerobic and anaerobic respiration tests. The RESPIROMETRIC sensor has a unique wireless control that transmits data directly to the PC through the wireless DataBox and RESPIROSoft™ software. The RESPIROMETRIC sensor has premium connectivity to the exclusive VELP Ermes Cloud Platform for remote control and remote assistance.

Supplier: Socorex Isba

Straw tip 1,1ml PP D=4mm L=190mm sterile (40x25 tips) 1 * 1.000 items

Supplier: EPPENDORF

Eppendorf epT.I.P.S.® Bulk packs offer a practical, high-volume solution with 'Eppendorf Quality' pipette tips, ensuring precise and reliable measurements for various lab applications, packaged economically for high-throughput settings.