"Bioss"

Supplier: Bioss

Possible negative regulator of polyubiquitination.

Supplier: Bioss

Protocadherins are a large family of cadherin-like cell adhesion proteins that are involved in the establishment and maintenance of neuronal connections in the brain. There are three protocadherin gene clusters, designated a, b and g, all of which contain multiple tandemly-arranged genes. PCDHB10 (protocadherin b10), also known as PCHB10 or PCDH-b10, is an 800 amino acid protein that is one of 16 proteins in the protocadherin b cluster. Unlike the a and g gene clusters, whose genes are spliced to downstream constant-region exons during transcription, members of the b cluster (such as PCDHB10) do not use constant-region exons to produce mRNAs. As a result, each protocadherin b gene encodes the transmembrane, extracellular and short cytoplasmic domains of the protein. Localized to the cell membrane, PCDHB10 is a single-pass type I membrane protein that contains six cadherin domains.

Supplier: Bioss

The ILK protein is important in different biological pathways such as cell adhesion, anchorage-dependent cell cycle progression, oncogenic transformation, and growth factor signaling. The kinase activity of ILK is low in non-activated cells; its activity is stimulated by cell-ECM interactions and by certain growth factors. 3 Negative regulation of ILK is mediated by two phosphatases: PTEN, a tumor suppressor lipid sphatase, and ILKAP, a PP2C protein phosphatase. In tumor cells that do not express PTEN protein, ILK is constitutively active.

Supplier: Bioss

The protein encoded by this gene is a member of the MAP kinase family. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. The activation of this kinase requires its phosphorylation by upstream kinases. Upon activation, this kinase translocates to the nucleus of the stimulated cells, where it phosphorylates nuclear targets. Two alternatively spliced transcript variants encoding the same protein, but differing in the UTRs, have been reported for this gene.

Supplier: Bioss

The proteasome represents a large protein complex that exists inside all eukaryotes and archaea, and in some bacteria. The main function of proteasomes is to degrade unnecessary or damaged proteins by proteolysis. The most common form of the proteasome, known as the 26S Proteasome, contains one 20S Proteasome core particle structure and two 19S regulatory caps. The 20S Proteasome core is hollow and forms an enclosed cavity, where proteins are degraded, as well as openings at the two ends to allow the target protein to enter. The 20S Proteasome core particle contains many subunits, depending on the organism. All of the subunits fall into one of two types: alpha subunits, which are structural, serve as docking domains for the regulatory particles and exterior gates blocking unregulated access to the interior cavity; or beta subunits, which are predominantly catalytic. The outer two rings in the proteasome consist of seven ?subunits each, and the inner two rings each consist of seven beta subunits.

Supplier: Bioss

CBLL1, also known as HAKAI (meaning destruction? in Japanese), or RNF188 (RING finger protein 188), is a 491 amino acid protein that contains one C2H2-type zinc finger and one RING-type zinc finger. CBLL1 is believed to function as an E3 ubiquitin-protein ligase that accepts a ubiquitin residue from an E2 ubiquitin-conjugating enzyme and immediately transfers that residue to a protein that is targeted for degradation. More specifically, upon activation of c-Src, CBLL1 interacts with and ubiquitinates tyrosine-phosphorylated E-cadherin, thereby targeting the E-cadherin complex for endocytosis and disrupting epithelial cell-cell contacts. Via its role as an E-cadherin regulator, CBLL1 participates in cell adhesion and may also be involved in the regulation of epithelial-mesenchymal transitions.

Supplier: Bioss

KLH conjugated synthesised phosphopeptide derived from human Pin1 around the phosphorylation site of Ser71.

Supplier: Bioss

STATHMIN 1 (SER24) POLYCLONAL ANTIBODY, ALEXA FLUOR® 680 CONJUGATED, HOST: RABBIT, CROSS REACTIVE SPECIES: HUMAN, MOUSE, RAT, APPLIC ATION: IF(IHC-P), CONCENTRATION: 1UG/UL, VOLUME: 100UL 1 * 100 µl

Supplier: Bioss

TSPAN15 POLYCLONAL ANTIBODY, ALEXA FLUOR® 750 CONJUGATED, HOST: RABBIT, CROSS REACTIVE SPECIES: HUMAN, MOUSE, RAT, APPLICATION: FCM, IF(IHC-P), CONCENTRATION: 1UG/UL, VOLUME: 100UL 1 * 100 µl

Supplier: Bioss

ANTI-HUMAN SEZ6 (ABBV-011 BIOSIMILAR)

Supplier: Bioss

CLEC4A - PE-Cy5.5 1 * 100 µl

Supplier: Bioss

DAT1 POLYCLONAL ANTIBODY, ALEXA FLUOR® 750 CONJUGATED, HOST: RABBIT, CROSS REACTIVE SPECIES: HUMAN, MOUSE, RAT, APPLICATION: IF(IHC- P), CONCENTRATION: 1UG/UL, VOLUME: 100UL 1 * 100 µl

Supplier: Bioss

ANTI-HUMAN ENPP3 CD203C (AGS-16C3F BIOSI 1 * 1 mg

Supplier: Bioss

AIF1 Polyclonal Antibody, AbBy Fluor® 405 Conjugated 1 * 100 µl

Supplier: Bioss

AMIGO3 POLYCLONAL ANTIBODY, ALEXA FLUOR® 680 CONJUGATED, HOST: RABBIT, CROSS REACTIVE SPECIES: HUMAN, APPLICATION: IF(IHC-P), CONCEN TRATION: 1UG/UL, VOLUME: 100UL 1 * 100 µl

Supplier: Bioss

HBSAG(H2F4) MONOCLONAL ANTIBODY, ALEXA FLUOR® 680 CONJUGATED, HOST: MOUSE, CROSS REACTIVE SPECIES: VIRUS, APPLICATION: IF(IHC-P), CO NCENTRATION: 1UG/UL, VOLUME: 100UL 1 * 100 µl