30614 Results for: "Assays&pageNo=20&view=list"

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Mouse Recombinant IFN-gamma

Supplier: STEMCELL Technologies

Interferon-gamma (IFN-γ), also known as type II interferon, is produced by T and NK cells, and in smaller amounts by dendritic cells and macrophages. IFN-γ is controlled by cytokines such as IL-12 and IL-18 secreted in response to infection (Schroder et al.). IFN-γ binds to a receptor complex and initiates signal transduction via the JAK/STAT pathway; this culminates in the transcription and activation of many genes that control a diverse array of immunological functions (De Weerd and Nguyen; Krause et al.). IFN-γ stimulates the antimicrobial and anti-tumor activity of macrophages, NK cells, and neutrophils (Billiau and Matthys) by promoting the activation of microbial effector functions such as production of reactive oxygen species, NO intermediates, complement, etc. (Schroder et al.). IFN-γ enhances MHC class I and II expression in dendritic cells and mononuclear phagocytes, as well as the production of IL-12 by dendritic cells. In B cells, IFN-γ stimulates survival and growth in both mouse and human cells, and redirects B cells from proliferation towards differentiation. IFN-γ favors the development of Th1 vs Th2 cells and stimulates monocyte differentiation and function (Schroder et al.).

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16 COMPONENTS MIX 1 * 5 Ampoul

Supplier: CUSTOM MADE CHEMICALS LAB

16 COMPONENTS MIX 1 * 5 Ampoul

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FILTER HPLC PEEK IN LINE WITH 2.0UM 1 * 10 items

Supplier: MICROSOLV

FILTER HPLC PEEK IN LINE WITH 2.0UM 1 * 10 items

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SUPER HT PAP PEN2 1 EA 1 * 1 Each

Supplier: Biotium

SUPER HT PAP PEN2 1 EA 1 * 1 Each

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Storage system 100/50/200 light grey,Standard part 1 * 1 items

Supplier: TRESTON

Storage system 100/50/200 light grey,Standard part 1 * 1 items

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SACCHARIMETER PLATO 14-21 0,1 20C 1 * 1 items

Supplier: GERING

SACCHARIMETER PLATO 14-21 0,1 20C 1 * 1 items

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Mouse Recombinant GM-CSF (E. coli expressed)

Supplier: STEMCELL Technologies

Granulocyte-macrophage colony-stimulating factor (GM-CSF) promotes the proliferation and differentiation of hematopoietic progenitor cells and the generation of neutrophils, eosinophils, and macrophages. In synergy with other cytokines such as stem cell factor, IL-3, erythropoietin, and thrombopoietin, it also stimulates erythroid and megakaryocyte progenitor cells (Barreda et al.). GM-CSF was first purified from the culture of mouse lung tissue after lipopolysaccharide treatment. GM-CSF is produced by multiple cell types, including stromal cells, Paneth cells, macrophages, dendritic cells (DCs), endothelial cells, smooth muscle cells, fibroblasts, chondrocytes, and Th1 and Th17 cells (Francisco-Cruz et al.). The receptor for GM-CSF (GM-CSFR) is composed of two subunits: the cytokine-specific α subunit (GMRα; CD116) and the common subunit βc (CD131) shared with IL-3 and IL-5 receptors (Broughton et al.). GM-CSFR is expressed on hematopoietic cells, including progenitor cells and immune cells, as well as non-hematopoietic cells. GM-CSF is able to stimulate the development of DCs that ingest, process, and present antigens to the immune system (Francisco-Cruz et al.).