11847 Results for: "3-[3-(Trifluoromethyl)phenoxy]azetidine+hydrochloride&pageNo=17&view=easy"

Supplier: ProSci Inc.

The gene encodes the DMRT1 protein is found in a cluster with two other members of the gene family, having in common a zinc finger-like DNA-binding motif (DM domain). The DM domain is an ancient, conserved component of the vertebrate sex-determining pathway that is also a key regulator of male development in flies and nematodes. This gene exhibits a gonad-specific and sexually dimorphic expression pattern. Defective testicular development and XY feminization occur when this gene is hemizygous. This suggested that DMRT1 may be required for testis development.This gene is found in a cluster with two other members of the gene family, having in common a zinc finger-like DNA-binding motif (DM domain). The DM domain is an ancient, conserved component of the vertebrate sex-determining pathway that is also a key regulator of male development in flies and nematodes. This gene exhibits a gonad-specific and sexually dimorphic expression pattern. Defective testicular development and XY feminization occur when this gene is hemizygous. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.

Supplier: Bioss

The matrix metalloproteinases (MMPs) are a family of at least eighteen secreted and membrane bound zincendopeptidases. Collectively, these enzymes can degrade all the components of the extracellular matrix, including fibrillar and non fibrillar collagens, fibronectin, laminin and basement membrane glycoproteins. In general, a signal peptide, a propeptide, and a catalytic domain containing the highly conserved zinc binding site characterizes the structure of the MMPs. In addition, fibronectin like repeats, a hinge region, and a C terminal hemopexin like domain allow categorization of MMPs into the collagenase, gelatinase, stomelysin and membrane type MMP subfamilies. All MMPs are synthesized as proenzymes, and most of them are secreted from the cells as proenzymes. Thus, the activation of these proenzymes is a critical step that leads to extracellular matrix breakdown. MMPs are considered to play an important role in wound healing, apoptosis, bone elongation, embryo development, uterine involution, angiogenesis and tissue remodeling, and in diseases such as multiple sclerosis, Alzheimer's, malignant gliomas, lupus, arthritis, periodontis, glumerulonephritis, atherosclerosis, tissue ulceration, and in cancer cell invasion and metastasis.MMP17 has been reported to be elevated in several tumor cell lines, and is constituitively produced by some normal cell lines. Treatment of cells with Concanavolin A or the phorbol ester TPA stimulates production of MMP17 in some cell types, and the enzyme can be recovered in cell lysates. Shed forms of MMP17 have also been reported.

Supplier: Bioss

The matrix metalloproteinases (MMPs) are a family of at least eighteen secreted and membrane bound zincendopeptidases. Collectively, these enzymes can degrade all the components of the extracellular matrix, including fibrillar and non fibrillar collagens, fibronectin, laminin and basement membrane glycoproteins. In general, a signal peptide, a propeptide, and a catalytic domain containing the highly conserved zinc binding site characterizes the structure of the MMPs. In addition, fibronectin like repeats, a hinge region, and a C terminal hemopexin like domain allow categorization of MMPs into the collagenase, gelatinase, stomelysin and membrane type MMP subfamilies. All MMPs are synthesized as proenzymes, and most of them are secreted from the cells as proenzymes. Thus, the activation of these proenzymes is a critical step that leads to extracellular matrix breakdown. MMPs are considered to play an important role in wound healing, apoptosis, bone elongation, embryo development, uterine involution, angiogenesis and tissue remodeling, and in diseases such as multiple sclerosis, Alzheimer's, malignant gliomas, lupus, arthritis, periodontis, glumerulonephritis, atherosclerosis, tissue ulceration, and in cancer cell invasion and metastasis.MMP17 has been reported to be elevated in several tumor cell lines, and is constituitively produced by some normal cell lines. Treatment of cells with Concanavolin A or the phorbol ester TPA stimulates production of MMP17 in some cell types, and the enzyme can be recovered in cell lysates. Shed forms of MMP17 have also been reported.

Supplier: EPPENDORF

The robust Reference® 2 is the successor to the Reference® pipette and features a new design, reduced weight and unique one-button operation.

Supplier: HELLMA

The Hellma® calibration standards comply with all necessary standards and regulations and thus offer the highest quality for recalibrating your spectrometer.

Supplier: Thermo Fisher Scientific

Based on Core Enhanced Technology, using 4 µm solid core particles, these columns allow users of conventional HPLC methods to enjoy performance far beyond that of columns packed with 5, 4 or even 3 μm fully porous particles. Very high separation efficiencies, using standard HPLC instruments and conditions, provide increased peak resolution and lower limits of detection. An ultra-stable packed bed results in exceptionally robust columns that demonstrate excellent retention and response reproducibility.

Supplier: ANTIBODIES.COM

Mouse IL-17A ELISA kit is a high sensitivity sandwich Enzyme-Linked Immunosorbent Assay (sELISA) designed for the in vitro quantitative determination of mouse IL-17A in serum, plasma, and other biological fluids.

Supplier: Q BIOANALYTIC

OneCup it‘s so easy! The OneCup assay comes along with a minimum of pipetting steps. Everything is included in the mix. You only need to combine 20 μl of the mix with 2 μl of your DNA sample and everything is ready. You have a minimum of hands-on time and avoid mistakes during pipetting. You can run the test on all common block cyclers. Application: Detection of Salmonella in food samples and environmental samples subsequent to a pre-enrichment step according to DIN EN ISO 20837 and 20838. In combination with an appropriate pre-enrichment and DNA preparation the test complies with the official method of the German food and feed law §64. ASU L00.00-98. Test principle: The test is dedicated to detect DNA of Salmonella in a sample using Real-Time PCR in compliance with the ISO method mentioned below. The kit uses the TaqMan® principle. Thus the requirements of the ISO standard, that an amplification product has to be confirmed by a hybridization step, is fulfilled. Each reactions contains an internal amplification control. Therefore, false negative results due to inhibition of the reaction can be excluded. The test included the UNG enzyme to prevent re-amplification of contaminating amplicons.

Supplier: THERMO MATRIX TECHNOLOGIES

Matrix™ tri-coded tubes combine the 2D matrix code with an improved linear and human-readable barcode.

Supplier: Portwest

These multi use high visible bodywarmer vests are specially designed for those who will not compromise on style, comfort, protection and performance. These garments are designed to keep warm, dry and visible in all conditions. The 300D Oxford Industry High Visibility provides comprehensive range of single and combination garments in a highly durable and cleverly designed innovative styles.

Supplier: ANTIBODIES.COM

Human IL-17A ELISA kit is a high sensitivity sandwich Enzyme-Linked Immunosorbent Assay (sELISA) designed for the in vitro quantitative determination of human IL-17A in serum, plasma, and other biological fluids.

Supplier: ANTIBODIES.COM

Mouse ISG15 ELISA Kit is a sandwich Enzyme-Linked Immunosorbent Assay (sELISA) designed for the in vitro quantitative determination of mouse ISG15 in serum, plasma, tissue homogenates, and other biological fluids.

Supplier: HUBER

Huber Unichillers offer better efficiency, stable pressure and delivery performance with a constant cooling water temperature compared to traditional tap water cooling.

Supplier: ProSci Inc.

Ubiquitin-Like Protein ISG15 (ISG15) is a ubiquitin-like protein that becomes conjugated to many cellular proteins upon activation by interferon-alpha and -beta. Several functions have been ascribed to the encoded protein, including chemotactic activity towards neutrophils, direction of ligated target proteins to intermediate filaments, cell-to-cell signalling, and antiviral activity during viral infections. While conjugates of this protein have been found to be noncovalently attached to intermediate filaments, this protein is sometimes secreted. ISG15 becomes conjugated to a diverse set of proteins after IFN-alpha/beta stimulation or microbial challenge. The functions or biochemical consequences ISG15 conjugation to proteins are not yet known, but it appears that this modification does not target proteins for proteasomal degradation. ISG15 shows specific chemotactic activity towards neutrophils and activates them to induce release of eosinophil chemotactic factors. Upon interferon treatment, ISG15 can be detected in both free and conjugated forms and is secreted from monocytes and lymphocytes where it can function as a cytokine. In the cell, ISG15 co-localises with intermediate filaments and ISGylation may modulate the JAK-STAT pathway or certain aspects of neurological disease.

Supplier: Sartorius Balances

Cubis® II MCE analytical balances with essential user interface offer a maximum weighing capacity between 120 and 520 g in combination with readability of 0.1 mg.

Supplier: Sartorius Balances

Cubis® II MCE high-capacity toploading balances with essential user interface offer a maximum load between 11,2 and 70,2 kg and readability between 0,1 and 1 g provide the ideal model for every application.

Supplier: Avantor

Avantor® ACE® Method Development Kits (MDK) are designed to maximize selectivity, offering a powerful and reliable approach to UHPLC/HPLC method development. Based upon an ultra-inert, high efficiency silica, Avantor® ACE® phases incorporate the latest developments in LC stationary phase design, providing chromatographers with more choices for alternative selectivity, without compromising stability or robustness. A complete range of kits for all requirements is available, including porous, solid core, HILIC and bioanalytical 300 Å column kits. These kits group together the essential column chemistries for method development and are available in a wide range of column formats.

Supplier: VWR Collection

These coats are made from Protect Xtra fabric which is a further development of the Protect fabric consisting of 100% polyester weave with conductive yarn (warp). This fabric has been especially designed for use in critical areas (e.g. operating rooms, sterile environments). Thanks to the PTFE finish, the coats provide very good splash protection against liquids and other contamination. The fabric has good tensile strength and provides very good resistance to microbial penetration.

Supplier: Avantor

Avantor® ACE® Method Development Kits (MDK) are designed to maximize selectivity, offering a powerful and reliable approach to UHPLC/HPLC method development. Based upon an ultra-inert, high efficiency silica, Avantor® ACE® phases incorporate the latest developments in LC stationary phase design, providing chromatographers with more choices for alternative selectivity, without compromising stability or robustness. A complete range of kits for all requirements is available, including porous, solid core, HILIC and bioanalytical 300 Å column kits. These kits group together the essential column chemistries for method development and are available in a wide range of column formats.

Supplier: Avantor

No matter what your requirements are for volumetric systems, HYDRA-POINT™ Karl Fischer reagents make water determination easy and trouble-free. They are pyridine-free and specially formulated for existing application procedures to give you consistent, reliable results for all types of samples.

Supplier: VWR Collection

VWR® Rigid PCR Plates feature a rugged polycarbonate frame, providing a solid and flat surface that guarantees seamless interaction with automated liquid handling platforms. With a firm grip assured, robots can confidently place VWR® Rigid PCR Plates with utmost precision, eliminating any concerns of misalignment.

Supplier: Sartorius Balances

Cubis® II MCA semi-micro balances with advanced user interface offer readability of 10 µg and a maximum weighing capacity up to 220 g. Used for weighing small sample amounts down to the µg-range.

Supplier: Quantabio

PerfeCTa® qPCR ToughMix® is a 2X concentrated ready to use reaction cocktail for PCR amplification of DNA templates that overcomes many known inhibitors of PCR often present in crude samples extracted from environmental specimens, plant tissues or animal tissues. It is a versatile and robust Real-Time qPCR reagent that provides maximum sensitivity and PCR efficiency with a variety of fluorogenic probe chemistries, including TaqMan® hydrolysis probes. PerfeCTa® qPCR ToughMix® contains all required reaction components, except primers, probe(s) and DNA template. The light blue colour of the AccuVue™ tracer dye simplifies reaction assembly in white, or clear plates and helps to minimise pipetting or mixing errors. It does not interfere with qPCR performance or affect the stability of the product.

Supplier: Sartorius Balances

Cubis® II MCA analytical balances with advanced user interface offer maximum weighing capacity between 120 and 520 g in combination with readability of 0.1 mg.

Supplier: Sartorius Balances

Cubis® II MCA high-capacity toploading balances with advanced user interface offer a maximum load between 11,2 and 70,2 kg and readability between 0,1 and 1 g provide the ideal model for every application.

Supplier: Sartorius

High quality pipettes with new, innovative design and technology, combining safety, ergonomics, efficiency in pipetting, with easy calibration and maintenance. They include built-in replaceable tip cone filters, which prevent pipette contamination and damage.

Supplier: Corning

These thermoconductive modules provide reproducible and standardised temperature control to biological samples while on the bench.

Supplier: Whatman products (Cytiva)

Mixed cellulose ester, WME range, circles, gridded. Whatman mixed cellulose ester membranes are composed of cellulose acetate and cellulose nitrate. These membranes are characterized by a smoother and more uniform surface than pure nitrocellulose filters.

Supplier: GA

Thermal transfer cryogenic labels that will firmly adhere to both ambient and already frozen surfaces (as low as -80 °C) without the need for thawing, cure time, or any other special treatment prior to long-term storage in liquid nitrogen (–196 °C).

Supplier: Greiner Bio-One

VACUETTE® tubes contain sodium citrate solutions in concentrations of 3,2% or 3,8% and are used for assays in haemostaseology. The mixing of 9 parts blood to 1 part sodium citrate takes place immediately after the blood is drawn by inverting the tube, causing anticoagulation through the binding of calcium.