112293 Results for: "2-Thiazolecarbonyl+chloride&pageNo=10&view=easy"

Supplier: STEMCELL Technologies

Neurotrophin-3 (NT-3) is a neurotrophic factor and a member of the nerve growth factor (NGF) family of proteins that includes neuron growth factor (NGF), brain-derived neurotrophic factor (BDNF), and neurotrophin-4/5. NT-3 signals a number of trophic effects through its transducing receptor tyrosine kinase TrkC. NT-3 is known to promote survival, development, and differentiation of neurons, and modulates transmitter release at several types of synapses in the peripheral and central nervous systems (Chalazonitis 1996). NT-3 has been shown to have an important role in the overall development of enteric neurons, which are crucial for gut peristalsis (Chalazonitis 2004). Studies in rats have shown the potential of NT-3 in dorsal column axonal regeneration (Bradbury et al.). NT-3 was shown to protect neurons against amyloid-β toxicity (Lesne et al.). NT-3 has applications in neuronal differentiation protocols to generate β-tubulin III+ peripheral neurons from neural crest stem cells (Menendez et al.) and oligodendrocyte precursor cells from human embryonic stem (ES) and induced pluripotent stem (iPS) cells (Douvaras et al.).

Supplier: MORGAN ADVANCED MATERIALS HALD

Alsint tiles square 200x200x10mm 1 * 1 items

Supplier: Merck

(TRIMETHYLSILYLMETHYL)LITHIUM 1.0M SOL 1 * 100 mL

Supplier: MORGAN ADVANCED MATERIALS HALD

Alsint tiles square,150x150x10mm 1 * 1 items

Supplier: AMETEK

[EN]CIRCULATOR BATH 28L MX CONTROL STAND 1 * 1 ST

Supplier: HAMILTON BONADUZ

calibrate with certificate 1 * 1 items

Supplier: Abnova

Recombinant protein, fpr1 (np_002020.1) recombinant protein without tag. 1 * 2 µG

Supplier: GERING

SACCHARIMETER 0-5: 0.05 BRIX + TH-TP27 1 * 1 items

Supplier: RAININ

[EN]PIPETTE MR-100 POS-D POSITIVE DISPLA

Supplier: Socorex Isba

MICROPIPETTE DILUTION ACURA810 1-0,1ML 1 * 1 items

Supplier: IKA

PLATE IN CERAMICS FOR VMS-C7 1 * 1 items

Supplier: DWK Life Sciences

FLASK ANTIBIOTIC MOISTURE CONTENT 1 * 1 items

Supplier: ZEISS

BINOCULAR PHOTOTUBE 20/23 100:0/0:100 1 * 1 items

Supplier: Merck

RPMI-1640 MEDIUM, WITH L-GLUTAMINE, WITHOUT SODIUM BICARBONATE. CELL CULTURE TESTED 1 * 1 Each

Supplier: Amarell

Viscometer-Therm., ähnlich Vogel-Ossag, ähnlich DIN 12785, 0+35:0,1°C, enclosed scale, capillary tube specially coated inside, with non-wetting blue special liquid, 470mm long, lower part solid stem 200x5mm, 208mm immersion, Richter-top finish, null

Supplier: TRESTON

Middle plate 90-130/100 L=150 1 * 1 items

Supplier: TRESTON

Middle plate 90-130/100 L=300 1 * 1 items

Supplier: STEMCELL Technologies

Interleukin 21 (IL-21) is a pleiotropic cytokine that is composed of four α-helical bundles and primarily produced by natural killer T (NKT) cells, T follicular helper (Tfh) cells, and Th17 cells (Spolski and Leonard 2008). IL-21 signals via heterodimers of the IL-21 receptor (IL-21R) and the IL2RG-encoded common cytokine receptor γ-chain (Parrish-Novak et al.; Ozaki K et al. 2000), and utilizes the JAK/STAT, MAPK, and PI3K pathways (Spolski and Leonard 2014). IL-21 has been shown to have a critical role in regulating immunoglobulin production and differentiation of the pro-inflammatory Th17 population of cells (Ozaki et al. 2002; Nurieva et al.). Additionally, IL-21 specifically sustains CD8+ T cell effector activity and provides a mechanism of CD4+ T cell help during chronic viral infection (Elsaesser et al.). IL-21 signaling was also found critical for the development of type 1 diabetes in NOD mice (Sutherland et al.) and control of T cell autoimmunity by regulatory B cells (Yoshizaki et al.). This product is animal component-free.

Supplier: STEMCELL Technologies

Interleukin 21 (IL-21) is a pleiotropic cytokine that is composed of four α-helical bundles and primarily produced by natural killer T (NKT) cells, T follicular helper (Tfh) cells, and Th17 cells (Spolski and Leonard 2008). IL-21 signals via heterodimers of the IL-21 receptor (IL-21R) and the IL2RG encoded common cytokine receptor γ-chain (Parrish-Novak et al.; Ozaki K et al. 2000), and utilizes the JAK/STAT, MAPK, and PI3K pathways (Spolski and Leonard 2014). IL-21 has been shown to have a critical role in regulating immunoglobulin production and differentiation of the pro-inflammatory Th17 population of cells (Ozaki et al. 2002; Nurieva et al.). Additionally, IL-21 specifically sustains CD8+ T cell effector activity and provides a mechanism of CD4+ T cell help during chronic viral infection (Elsaesser et al.). IL-21 signaling was also found critical for the development of type 1 diabetes in NOD mice (Sutherland et al.) and control of T cell autoimmunity by regulatory B cells (Yoshizaki et al.).

Supplier: Merck

CITRATE CONCENTRATED SOLUTION BIOREAGENT, SUITABLE FOR COAGULATION ASSAYS, 4 % (W/V) 1 * 1 Each

Supplier: STEMCELL Technologies

Interleukin 15 (IL-15) is a four-alpha helix bundle cytokine with many similar properties to IL-2. The IL-15 receptor is a heterotrimeric receptor composed of IL-15Ra (the high-affinity receptor for IL-15), as well as IL-2/15Rb (CD122) and common gamma chain (CD132). IL-15 binds to IL-15Rα receptor and can then be presented in trans to IL-2/15Rb and common gamma chain on other cells. Trans-presentation is thought to be the major mechanism by which IL-15-mediated responses occur in mice, although may not be necessary in humans (Castillo et al.). The cytoplasmic domains of IL-2/15Rb and common gamma chain mediate signaling to activate JAK/STAT and PI3K pathways. IL-15 supports the survival and proliferation of naïve CD4+ and CD8+ T cells, and promotes homeostasis of memory T cells. IL-15 also promotes the survival and differentiation of NK cells and regulates their cytolytic activity (Ma et al.). This product is animal component-free.

Supplier: STEMCELL Technologies

Interleukin 1 beta (IL-1β) is synthesised as an inactive precursor protein or pro-IL-1β. This precursor is cleaved intracellularly by caspase 1 (IL-1β convertase) to form the active form of the protein that is later secreted (Allan et al.). IL-1β binds to IL-1 receptor and activates intracellular signaling via the MAPK or NF-kB pathway. IL-1β is released by monocytes, tissue macrophages, and dendritic cells in response to infection or injury and induces expression of acute-phase proteins. It also promotes the infiltration of inflammatory and immunocompetent cells from the circulation into the extravascular space and affected tissues, by stimulating the expression of adhesion molecules on endothelial cells. IL-1β also affects other immune cells; for example, it co-stimulates T cell functions together with antigen or mitogen. It also stimulates Th17 differentiation and B cell proliferation in an IL-6-dependent manner. Mice deficient in IL-1β do not show phenotypical differences from wild-type mice; however, they have a reduced response to inflammation, suggesting that IL-1β plays a key role in inflammatory diseases (Dinarello).

Supplier: Abnova

Recombinant protein, adrb2 (np_000015.1) recombinant protein without tag. 1 * 2 µG

Supplier: SARSTEDT

Demeter-Pipette 1,1ml 1 * 1.000 items

Supplier: SciLabware

BOTTLE REAGENT WIDE NECK 10L 1 * 1 items

Supplier: TRESTON

Hook R10, L33 (5pcs),L33 (5pcs) 1 * 1 items

Supplier: TOSOH Bioscience

COLUMN TSKGEL GUARD SUPERHZ-H 10µM 1 * 1 items

Supplier: Abnova

Recombinant protein, gpr55 (np_005674.2) recombinant protein without tag. 1 * 2 µG

Supplier: HIRSCHMANN

Suction tube . 400 mm for em-dispenser up to 10ml 1 * 1 items

Supplier: SAMCO

PASTEUR PIPETTE 7,7 mL, POLYETHYLENE 1 * 500 items