112306 Results for: "2-Thiazolecarbonyl+chloride&pageNo=10&view=easy"

Supplier: Portwest

A highly innovative and functional jacket that provides seven wearer combinations. This extremely versatile jacket is highly adaptable to all weather conditions and is certified to the highest in waterproof and breathable standards.

Supplier: ProSci Inc.

Interleukin-2 (IL-2) is a 133 amino acid glycoprotein with one intramolecular disulphide bond and variable glycosylation. It is secreted by activated T cells and induces proliferation and maturation of activated T cells, natural killer cells and lymphokine activated killer cells. IL-2 also stimulates proliferation of antibody-producing B cells, activates neutrophils and induces mononuclear cells to secrete IFN-gamma and TNF-alpha and -beta. Moreover, studies have shown that IL-2 is required for activation-induced apoptosis, an important homeostatic mechanism in the immune system, which is involved in the maintenance of peripheral tolerance to self-antigens. IL-2 promotes T cell proliferation and particularly naive T cells. IL-2 signalling on activated T cells is effected through a quaternary high-affinity receptor complex consisting of IL-2, IL-2Ralpha (CD25), IL-2Rbeta and IL-2Rgamma. Naive T cells are relatively insensitive to IL-2 as they only express small amounts of IL-2Rbeta and IL-2Rgamma. They only acquire sensitivity after CD25 expression, which captures the cytokine and presents it to the IL-2Rbeta and IL-2Rgamma receptors. IL-2 Superkine (Fc) is an artificial variant of IL-2 containing mutations at positions L80F / R81D / L85V / I 86V / I92F. These mutations are located in the molecule's core that acts to stabilize the structure and to give it a receptor-binding conformation mimicking native IL-2 bound to CD25. These mutations effectively eliminate the functional requirement of IL-2 for CD25 expression and elicit proliferation of T cells. Compared to IL-2, the IL-2 superkine induces superior expansion of cytotoxic T cells, leading to improved antitumor responses in vivo, and elicits proportionally less toxicity by lowering the expansion of Tregulatory cells and reducing pulmonary oedema.

Supplier: ProSci Inc.

Receptors for the Fc region of immunoglobin G (Fc gamma R) are divided into three classes and Fc gamma RIII is a multifunctional, low/intermediate affinity receptor. In humans, Fc gamma RIII is expressed as two distinct forms (Fc gamma RIIIA and Fc gamma RIIIB) that are encoded by two different but highly homologous genes in a cell type-specific manner. Fc gamma RIIIB is a low-affinity, GPI-linked receptor expressed by neutrophils and eosinophils, whereas Fc gamma RIIIA is an intermediate affinity polypeptide-anchored transmembrane glycoprotein expressed by a subset of T lymphocytes, natural killer (NK) cells, monocytes, and macrophages. The Fc gamma RIIIA receptor is involved in phagocytosis, secretion of enzymes, inflammatory mediators, antibody-dependent cellular cytotoxicity (ADCC), mast cell degranulation, and clearance of immune complexes. Fc gamma RIIIA has an immunoreceptor tyrosine-based activation motif (ITAM) in its cytoplasmic domain and delivers an activation signal in the immune responses. Aberrant expression or mutations in this gene is implicated in susceptibility to recurrent viral infections, systemic lupus erythematosus, and alloimmune neonatal neutropenia. In humans, it is a 50 -70 kD type I transmembrane activating receptor. The Fc gamma RIIIA cDNA encodes 254 amino acid including a 16aa signal sequence, 191 amino acid ECD with two C2-type Ig-like domains, five potential N-glycosylation sites, a 22 amino acid transmembrane sequence and a 25 amino acid cytoplasmic domain.

Supplier: Thermo Fisher Scientific

For customers in cell and gene therapy and vaccine production, the CryoMed with OPC UA provides precise, repeatable freezing results that protect samples from intracellular freezing. The CryoMed features OPC UA serial communication (ethernet) capabilities, comes standard factory certifications, provides enhanced data traceability via a touch screen user interface and offers customizable freezing profiles while supporting 21 CFR part 11 and GMP needs.

Supplier: IKA

KNOB OPERATING FOR MF 10.2 1 * 1 items

Supplier: MEMMERT

CO2-contr.with CO2,rh-sensor,mod.153 Exchange-set, calibr.,steri.sensor 1 * 1 items

Supplier: VACUUBRAND

VACUU·LAN® module body B6: With front connection M35x1.5mm for operating parts C and rear 1 * 1 items

Supplier: Amarell

Precision thermometer, DIN, Mod-L25924, Brand-Amarell, Range : -5 to +100oC,270mm, Div: 0.5oC, VC 1 * 1 items

Supplier: BOCHEM

FORCEP SS 18/8 LENGTH 115MM BLUNT 1 * 1 items

Supplier: SARSTEDT

URISET 24 WITH LIGHT PROTECTION 1 * 30 items

Supplier: P D UMWELTSCHUTZ UND PRUEFGERA

Federklammer für Erlenmeyerkolben 100 ml 1 * 1 ST

Supplier: witeg Labortechnik

ROCKER 901 OIL-FREE ROTARY VANE PUMP 1 * 1 items

Supplier: Epredia

Microslide 90° frosted 20mm glass cello ISO 8037/1 1,0mm 1 * 2.000 items

Supplier: Epredia

Microslide Superfrost 90° CC yellow glass cello ISO 8037/1 1,0mm 1 * 2.000 items

Supplier: TIGER-VAC

PVC-Hose for CR-4D #323301B PVC,conductive, colour beige, 32mm x 3 m, Connector:chrome plated 1 * 1 Each

Supplier: CAMAG

GLASS COVER PLATE 143X143X4 FOR HDC 10X10 022.8500/30 1 * 1 items

Supplier: VICI JOUR RESEARCH

TUBING, PREMIUM, SS, 1/16'' OD X 1.00 MM 1 * 3 m

Supplier: Epredia

Microslide Superfrost 90° CC yellow glass cello ISO 8037/1 1,0mm 1 * 1.000 items

Supplier: BIOCISION

TU 3.8 EXT 3CD CP 48RK 10CA 1 * 1 items

Supplier: ROCHE

PHOSSTOP

Supplier: NEUBERT VOLUME GLASSWAERE

APPARATUS FOR DETERMINING ESSENTIAL OIL 1 * 1 items

Supplier: RAININ

Shaft 10µl Pipet-Lite EDP3-Plus EDP3-Basic 1 * 1 items

Supplier: TIGER-VAC

PVC-Hose for MV-1CR #212072 PVC, conductive, Colour beige, 32mm x 3,0 m, Connector: Stainless steel 1 * 1 Each

Supplier: VICI JOUR RESEARCH

FILTER SS ECONOMY MOBIL PHASE 10UM 1 * 2 items

Supplier: Epredia

Microslide Superfrost 45° white glass with box cello ISO 8037/1 1,0mm 1 * 2.000 items

Supplier: Simport Scientific

DEEP WELL PLATE 384 V BOTTOM SQUARE WELL 1 * 50 items

Supplier: Epredia

Microslide Superfrost 90° CC green glass with box cello ISO 8037/1 1,0mm 1 * 2.000 items

Supplier: WINDRUSH TECHNOLOGY

WR-Vakuumpumpe-FV-60-240 240 Volt, Hepa-Filter, 2,5 l /min. (Für 8´ u.12´ Wafer) 1 * 1 Pack.

Supplier: IUL Instruments SA

BAG BLENDER 400ML IRRADIATED 10X10 1 * 5.000 items

Supplier: Merck

RINK RESIN, 100-200 MESH, 1% CROSS-LINKE D,0.4-0.6 MMOL N/G 1 * 5 g