30484 Results for: "2-(Difluoromethoxy)iodobenzene&pageNo=20&view=list"

Supplier: STEMCELL Technologies

Granulocyte-macrophage colony-stimulating factor (GM-CSF) promotes the proliferation and differentiation of hematopoietic progenitor cells and the generation of neutrophils, eosinophils, and macrophages. In synergy with other cytokines such as stem cell factor, IL-3, erythropoietin, and thrombopoietin, it also stimulates erythroid and megakaryocyte progenitor cells (Barreda et al.). GM-CSF is produced by multiple cell types, including stromal cells, Paneth cells, macrophages, dendritic cells (DCs), endothelial cells, smooth muscle cells, fibroblasts, chondrocytes, and Th1 and Th17 T cells (Francisco-Cruz et al.). The receptor for GM-CSF (GM-CSFR) is composed of two subunits: the cytokine-specific α subunit (GMRα; CD116) and the common subunit βc (CD131) shared with IL-3 and IL-5 receptors (Broughton et al.). GM-CSFR is expressed on hematopoietic cells, including progenitor cells and immune cells, as well as non-hematopoietic cells. Recombinant human GM-CSF (rhGM-CSF) promotes the production of myeloid cells of the granulocytic (neutrophils, eosinophils and basophils) and monocytic lineages in vivo. It has been tested for mobilization of hematopoietic progenitor cells and for treating chemotherapy-induced neutropenia in patients. GM-CSF is able to stimulate the development of DCs that ingest, process, and present antigens to the immune system (Francisco-Cruz et al.).

Supplier: STEMCELL Technologies

Ciliary neurotrophic factor (CNTF) is a neurotrophic factor that belongs to the four-helix bundle cytokine family and is structurally related to interleukin 6 (IL-6), interleukin 11 (IL-11), leukemia inhibitory factor (LIF), and oncostatin M (OSM). CNTF binds to its receptor CNFTRα and induces formation of a heterodimer of the signal transducing IL-6 receptor gp130 and LIF receptor (LIFR)-β, which triggers JAK/STAT, ERK, and PI3K signaling cascades (Schuster et al.). CNTF plays an important role in neurogenesis and the differentiation of neural stem cells and has been suggested to possess a therapeutic role in treating neurological disorders (Ding et al.; Oppenheim et al.). CNTF has also been shown to protect rod photoreceptors from light-induced damage and have therapeutic effects on retinal degenerative diseases caused by genetic defect or damage induced by toxins, autoantibodies, or strong light (Pernet et al.; Rhee et al.). Another therapeutic role of CNTF has been reported in protecting oligodendrocytes from death induced by apoptosis (Louis et al.). Additionally, CNTF is commonly used to differentiate human pluripotent stem cell (hPSC)-derived neural progenitor cells into astrocytes (Krencik and Zhang). This product is animal component-free.

Supplier: STEMCELL Technologies

Vascular endothelial growth factor (VEGF) is a heparin-binding homodimeric glycoprotein involved in vasculogenesis and angiogenesis. VEGF binds to FLT1 (VEGFR-1) and KDR (VEGFR-2), and activates Raf/MEK/ERK and PI3K/AKT pathways (Ferrara et al.). VEGF exists in multiple isoforms that result from alternative splicing of VEGF mRNA in the terminal exon. Proximal splice-site selection in exon 8 results in pro-angiogenic VEGFxxx isoforms (xxx is the number of amino acids), whereas distal splice-site selection results in anti-angiogenic VEGFxxxb isoforms (Nowak et al.). VEGF plays an important role in neurogenesis both in vitro and in vivo (Storkebaum et al.). It has neurotrophic effects on neurons of the central nervous system, and it promotes growth and survival of dopaminergic neurons and astrocytes. VEGF also promotes growth and survival of vascular endothelial cells, monocyte chemotaxis, and colony formation by granulocyte-macrophage progenitor cells (Ferrara et al.). Various splice variants of VEGF exist, with different functions. For example, it has been shown that VEGF isoform VEGF-164(165) and not VEGF-120(121) induces inflammation, stimulates intracellular adhesion molecule (ICAM)-1 expression on endothelial cells, and induces chemotaxis of monocytes (Usui et al.).

Supplier: OMEGA BIO-TEK

The E.Z.N.A.® Plasmid Maxi Kit is the maxi scale system to deliver high-quality plasmid DNA using the spin column format, without costly accessories. The HiBind® DNA Maxi column facilitates the binding, washing, and elution steps, thus enabling multiple samples to be simultaneously processed. Although yields vary according to plasmid copy number, E.coli strain, and conditions of growth, 50 to 200 ml of overnight culture in LB medium typically produces 0,5 to 1 mg of high copy number plasmid DNA. Up to 500 ml of culture may be processed when working with low copy number plasmid. The product is suitable for automated fluorescent DNA sequencing (typical reads exceed 800 bp), restriction enzyme digestion, transfection of mammalian cells, transcription invitro, and other applications.

Supplier: Sartorius Balances

The Cubis® II laboratory balances are modular, therefore they allow to choose between applications and configurations which suit the best to the needs. These balances can be configured at the level of display, draftshields, software applications and hardware functions.

Supplier: MACHEREY-NAGEL

TLC precoated plates CEL 300-25 size: 10x20 cm pack of 50 1 * 50 items

Supplier: Sartorius Balances

The Cubis® II laboratory balances are modular, therefore they allow to choose between applications and configurations which suit the best to the needs. These balances can be configured at the level of display, draftshields, software applications and hardware functions.

Supplier: MACHEREY-NAGEL

Extraction thimbles MN 645 W Format:20x80mm (Inner diameterxHeight) pack of 25. 1 * 25 items

Supplier: MACHEREY-NAGEL

Vessel PTFE pressure 20ml for decomposition with safety expansion reservoir incl. set of sealing discs/safety diaphragms NANOCOLOR. 1 * 1 items

Supplier: Amarell

Alcoholometer, EUROPA classII, measuring range:80-90:0.1%vol, without thermometer, length:360mm, reference temperature: 20C, suitab le for government verification. 1 * 1 items

Supplier: Biotium

EvaGreen® Dye and high-performance dye-based qPCR master mixes containing EvaGreen® qPCR dye, Cheetah™ HotStart Taq Polymerase, and Forget-Me-Not™ tracking dye. Available with 2-colour tracking or pre-mixed with low or high ROX.

Supplier: Amarell

Alcoholometer, EUROPA classII, measuring range:70-80:0.1%vol, without thermometer, length:360mm, reference temperature: 20C, suitab le for government verification. 1 * 1 items

Supplier: Amarell

Alcoholometer, EUROPA classII, measuring range:60-70:0.1%vol, without thermometer, length:360mm, reference temperature: 20C, suitab le for government verification. 1 * 1 items

Supplier: Corning

RECTANGULAR BOTTLE 500ML HDPE NA GRADUATED H200 Ø20 + TAMPER-EVIDENT SCREW CAP WITH SHAPED SEAL WH 1 * 170 items

Supplier: Amarell

Alcoholometer, EUROPA classII, measuring range:50-60:0.1%vol, without thermometer, length:360mm, reference temperature: 20C, suitab le for government verification. 1 * 1 items

Supplier: Amarell

Alcoholometer, EUROPA classII, measuring range:90-100:0.1%vol, without thermometer, length:360mm, reference temperature: 20C, suita ble for government verification. 1 * 1 items

Supplier: Corning

250ML PE RECTANGULAR & GRADUATED BOTTLE, 25G, Ø20, WHITE CAP SEPARATED 1 * 312 items

Supplier: Amarell

Alcoholometer, EUROPA classII, measuring range:40-50:0.1%vol, without thermometer, length:360mm, reference temperature: 20C, suitab le for government verification. 1 * 1 items

Supplier: BIGNEAT

HPL Flat Base, 800mm wide 1 * 1 items

Supplier: Corning

RECTANGULAR BOTTLE 250ML HDPE NA GRADUATED H155 Ø20 & TAMPER-EVIDENT SCREW CAP WITH SHAPED SEAL WH 1 * 312 items

Supplier: Cytiva

illustra™ ExoProStar™ contains illustra™ Alkaline Phosphatase and Exonuclease 1, formulated to work together to remove unincorporated primers and nucleotides from amplification reactions in preparation for sequencing, cloning, genotyping or further DNA modification reactions.

Supplier: HIRSCHMANN

Flask volumetric, capacity 20ml, class A, amber graduated, poly stoppered, tolerance 0.04ml, height 110mm, NS-ground 10/19, graduati on color white, conformity certified,DIN/ISO product with single certificate. 1 * 1 items

Supplier: MP Biomedicals

SPINeasy® DNA Kit for Yeast is a high-performance genomic DNA (gDNA) extraction kit which is developed based on silica-membrane spin-column technology. This kit enables quick isolation of gDNA from yeast cells, typically in less than 30 minutes.

Supplier: Corning

RECTANGULAR BOTTLE 500ML PP NATURAL GRADUATED H200 Ø20 & TAMPER EVIDENT RED SCREW CAP WITH SHAPED SEAL, IND. WRAPP., IONISED 1 * 100 items

Supplier: Corning

Microplate 96 well polystyrene black with clear flat bottom poly-D-lysine treated with lid aseptically manufactured sterile 1 * 100 items

Supplier: MACHEREY-NAGEL

Reagent case-new design-for determination of temperature, pH 4-9, alkalinity, oxygen, total hardness, ammonium, nitrite, phosphate w ith ECO- and titration test kits VISOCOLOR. 1 * 1 SET

Supplier: MP Biomedicals

SPINeasy® DNA Kit for Microbiome employs a novel method for isolating microbial genomic DNA from various samples. Due to its highly effective lysis capability and silica-membrane spin-column technology, the SPINeasy® DNA Kit for Microbiome can be used for bacterial, body fluids and environmental samples such as soil and stool.

Supplier: OMEGA BIO-TEK

The Mag-Bind® Endo-free Plasmid Mini Kit is designed to deliver high-quality, plasmid DNA with endotoxin levels <0,1 EU/μg for use in eukaryotic transfections and other sensitive in vitro applications.

Supplier: MP Biomedicals

The Fast DNA® SPIN Kit is used with the FastPrep®-24 or FastPrep® FP120 instrument to lyse and subsequently isolate DNA from up to 200 mg of almost any sample in less than 30 minutes.

Supplier: BIOO SCIENTIFIC

The CRISPRclean® stranded total RNA prep with rRNA depletion (HMR + pan bacteria) is a total RNA library prep leveraging a CRISPR-powered workflow facilitating the detection of lower expressing and biologically relevant transcripts from complex samples.