TW-37 ≥98%

Small-molecule inhibitor of BCL-2 (Ki = 0,29 μM). Inhibits multiple BCL-2 family members including BCL-XL (Ki = 1,11 μM) and MCL-1 (Ki= 0,26 μM). Binds to the BCL-2 homology domain 3 (BH3) groove of BCL-2. Significant anti-proliferative and pro-apoptotic activity in lymphoma cells.

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