1,9-Pyrazoloanthrone ≥99% JNK inhibitor

Potent and selective JNK1, -2, and -3 inhibitor (IC₅₀ = 0,11 μM). SP600125 is a reversible ATP-competitive inhibitor with 20-fold selectivity over a range of kinases. It dose-dependently inhibits the phosphorylation of c-Jun and the expression of infla mMatory genes COX-2, IL-2, IFNγ and TNFα. Neuroprotective in vivo.

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