Product to be used as a negative control for ErbB 2 Affibody® Molecule Imaging Agent.

The product (denoted Z03638) is an engineered variant of the Taq Polymerase binder Z01155, where 11 amino acids in the scaffold have been changed in order to resemble the Affibody® Imaging Agents.

It contains a unique C-terminal cysteine for directed chemical modifications. However, tail-to-tail dimers are spontaneously generated via a disulfide bridge between the C-terminal cysteines. Prior to coupling via the C-terminal cysteine, the Affibody® molecule needs to be reduced to expose the reactive cysteine residue. Recommended reducing condition is 20 mM DTT at a pH above 7.5 and incubation at room temperature for 2 hours. Remove excess DTT by passage through a desalting column, not by dialysis.

All products are FOR RESEARCH USE ONLY. PRODUCTS ARE NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES. Customer is granted a limited use non-exclusive licence for its own internal research. Any control manufacturer supplies with a product is limited to use only to validate the relevant product. By using the product, customers agree not to attempt to reverse engineer or otherwise perform any compositional, structural, functional or other analyses directed to learning the methodology, formulae, sequences, processes, make-up or production of any of the products or portions thereof.