Specifications
- Antibody type:Primary
- Antigen name:WD repeat-containing protein 48
- Antigen symbol:WDR48
- Clonality:Polyclonal
- Conjugation:Unconjugated
- Flow cytometry:Yes
- Host:Rabbit
- ImmunoChemistry:Yes
- Reactivity:Human
- Western blot:Yes
- Epitope:Amino Acid Range = 603-630
- Form:Liquid
- Gene ID:Q8TAF3
- Antigen synonyms:WDR48
- Modification:None
- Storage buffer:Supplied in PBS with 0,09% (W/V) sodium azide
- Molecular weight:76 kDa
- Storage temperature:Store at 4 °C for three months and –20 °C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
- Concentration:0,4 mg/ml
- Shipping temperature:4 °C
- Immunogen:This WDR48 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 603-630 amino acids from the C-terminal region of human WDR48.
- Purification:This antibody is purified through a protein A column, followed by peptide affinity purification.
- Size:400 µl
- Pk:400 µl
Specifications
About this item
Regulator of deubiquitinating complexes. Acts as a strong activator of USP1 by enhancing the USP1-mediated deubiquitination of FANCD2; USP1 being almost inactive by itself. Also activates deubiquitinating activity of complexes containing USP12 and USP46, respectively. Activates deubiquitination by increasing the catalytic turnover without increasing the affinity of deubiquitinating enzymes for the substrate. In case of infection by Herpesvirus saimiri, may play a role in vesicular transport or membrane fusion events necessary for transport to lysosomes. Induces lysosomal vesicle formation via interaction with Herpesvirus saimiri tyrosine kinase-interacting protein (TIP). Subsequently, TIP recruits tyrosine-protein kinase LCK, resulting in down-regulation of T-cell antigen receptor TCR. May play a role in generation of enlarged endosomal vesicles via interaction with TIP. In case of infection by papillomavirus HPV11, promotes the maintenance of the viral genome via its interaction with HPV11 helicase E1.
For WB starting dilution is: 1:1000. For IHC-P starting dilution is: 1:50~100. For FACS starting dilution is: 1:10~50.
Type: Primary
Antigen: WDR48
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope:
Host: Rabbit
Isotype: Rabbit Ig
Reactivity: Human