The United States Pharmacopeia (USP)<467> residual solvents is a widely used compendial method intended for identifying and quantifying residual solvents in drug substances, drug products, and excipients.

In an attempt to better mirror the International Conference on Harmonization (ICH)guidelines, the USP has adopted a more comprehensive methodology in residual solvent testing-the current USP30/NF25. The ICH publishes a guideline (Q3C) listing the acceptable amounts of solvent residues that can be present. In the ICH guideline, residual solvents are summarised by class according to their toxicity.