Human Recombinant IL-17A (from E. coli)
About this item
Interleukin 21 (IL-21) is a member of the common-gamma chain family of cytokines that are involved in immunoregulation. IL-21 is normally expressed by activated CD4+ T cells and is aberrantly expressed in Hodgkin lymphoma cells. The IL-21 receptor (IL-21R) activates the JAK/STAT signaling pathway and is expressed on T, B, and natural killer (NK) cells.
- High quality
- Low endotoxin
- Affordable
Within the B cell lineage, IL-21 is a switch factor regulating IgG1 and IgG3 antibody production. IL-21 also cooperates with IL-4 for the production of multiple antibody classes in B cells. IL-21 has pleiotropic effects on the proliferation, differentiation, and effector functions of B, T, NK, and dendritic cells.
Elevated levels of IL-17A are associated with rheumatoid arthritis, airway inflammation, allograft rejection, inflammatory bowel disease, psoriasis, cancer, and multiple sclerosis. Human, mouse, and rat IL-17A show activity on mouse cells.
Delivery information: Certificate of analysis (COA) is supplied with each product shipped detailing purity, formulation, biological activity, endotoxin levels, reconstitution instructions and recommended storage conditions.
Caution: For research use only.
5 Options Available Below
Product Details & Documents
Interleukin 21 (IL-21) is a member of the common-gamma chain family of cytokines that are involved in immunoregulation. IL-21 is normally expressed by activated CD4+ T cells and is aberrantly expressed in Hodgkin lymphoma cells. The IL-21 receptor (IL-21R) activates the JAK/STAT signaling pathway and is expressed on T, B, and natural killer (NK) cells.
- High quality
- Low endotoxin
- Affordable
Within the B cell lineage, IL-21 is a switch factor regulating IgG1 and IgG3 antibody production. IL-21 also cooperates with IL-4 for the production of multiple antibody classes in B cells. IL-21 has pleiotropic effects on the proliferation, differentiation, and effector functions of B, T, NK, and dendritic cells.
Elevated levels of IL-17A are associated with rheumatoid arthritis, airway inflammation, allograft rejection, inflammatory bowel disease, psoriasis, cancer, and multiple sclerosis. Human, mouse, and rat IL-17A show activity on mouse cells.
Delivery information: Certificate of analysis (COA) is supplied with each product shipped detailing purity, formulation, biological activity, endotoxin levels, reconstitution instructions and recommended storage conditions.
Caution: For research use only.
Specifications for Product Family
Specifications
Specifications
- Catalog No:
- SHBT100-87-5UG
- SHBT100-87-25UG
- SHBT100-87-100UG
- SHBT100-87-500UG
- SHBT100-87-1MG
- Protein/peptide name:
- IL-17A
- IL-17A
- IL-17A
- IL-17A
- IL-17A
- Protein synonyms:
- IL-17|CTLA-8
- IL-17|CTLA-8
- IL-17|CTLA-8
- IL-17|CTLA-8
- IL-17|CTLA-8
- Protein/peptide type:
- Recombinant
- Recombinant
- Recombinant
- Recombinant
- Recombinant
- Protein function:
- Cytokine
- Cytokine
- Cytokine
- Cytokine
- Cytokine
- Species:
- Human
- Human
- Human
- Human
- Human
- Source:
- E. coli
- E. coli
- E. coli
- E. coli
- E. coli
- Conjugation:
- Unconjugated
- Unconjugated
- Unconjugated
- Unconjugated
- Unconjugated
- Gene ID:
- Q16552
- Q16552
- Q16552
- Q16552
- Q16552
- Sequence:
- MIVKAGITIP RNPGCPNSED KNFPRTVMVN LNIHNRNTNT NPKRSSDYYN RSTSPWNLHR NEDPERYPSV IWEAKCRHLG CINADGNVDY HMNSVPIQQE ILVLRREPPH CPNSFRLEKI LVSVGCTCVT PIVHHVA
- MIVKAGITIP RNPGCPNSED KNFPRTVMVN LNIHNRNTNT NPKRSSDYYN RSTSPWNLHR NEDPERYPSV IWEAKCRHLG CINADGNVDY HMNSVPIQQE ILVLRREPPH CPNSFRLEKI LVSVGCTCVT PIVHHVA
- MIVKAGITIP RNPGCPNSED KNFPRTVMVN LNIHNRNTNT NPKRSSDYYN RSTSPWNLHR NEDPERYPSV IWEAKCRHLG CINADGNVDY HMNSVPIQQE ILVLRREPPH CPNSFRLEKI LVSVGCTCVT PIVHHVA
- MIVKAGITIP RNPGCPNSED KNFPRTVMVN LNIHNRNTNT NPKRSSDYYN RSTSPWNLHR NEDPERYPSV IWEAKCRHLG CINADGNVDY HMNSVPIQQE ILVLRREPPH CPNSFRLEKI LVSVGCTCVT PIVHHVA
- MIVKAGITIP RNPGCPNSED KNFPRTVMVN LNIHNRNTNT NPKRSSDYYN RSTSPWNLHR NEDPERYPSV IWEAKCRHLG CINADGNVDY HMNSVPIQQE ILVLRREPPH CPNSFRLEKI LVSVGCTCVT PIVHHVA
- Protease-free:
- N
- N
- N
- N
- N
- Animal-free:
- N
- N
- N
- N
- N
- Nuclease-free:
- N
- N
- N
- N
- N
- Carrier-free:
- Y
- Y
- Y
- Y
- Y
- Endotoxin-free:
- N
- N
- N
- N
- N
- Endotoxin level:
- Low
- Low
- Low
- Low
- Low
- Endotoxin content:
- Endotoxin LAL (EU/µg) ≤0.1
- Endotoxin LAL (EU/µg) ≤0.1
- Endotoxin LAL (EU/µg) ≤0.1
- Endotoxin LAL (EU/µg) ≤0.1
- Endotoxin LAL (EU/µg) ≤0.1
- UniProtKB:
- Q16552
- Q16552
- Q16552
- Q16552
- Q16552
- Biological activity:
- Bioactivity assay: Production of IL-6 from mouse 3T3 cells, ED50 ≤10 ng/ml, bioactivity ≥1,0×10⁵ units/mg
- Bioactivity assay: Production of IL-6 from mouse 3T3 cells, ED50 ≤10 ng/ml, bioactivity ≥1,0×10⁵ units/mg
- Bioactivity assay: Production of IL-6 from mouse 3T3 cells, ED50 ≤10 ng/ml, bioactivity ≥1,0×10⁵ units/mg
- Bioactivity assay: Production of IL-6 from mouse 3T3 cells, ED50 ≤10 ng/ml, bioactivity ≥1,0×10⁵ units/mg
- Bioactivity assay: Production of IL-6 from mouse 3T3 cells, ED50 ≤10 ng/ml, bioactivity ≥1,0×10⁵ units/mg
- Purity:
- ≥95%
- ≥95%
- ≥95%
- ≥95%
- ≥95%
- Grade:
- RUO
- RUO
- RUO
- RUO
- RUO
- Formulation:
- 0,1% Trifluoroacetic Acid (TFA)
- 0,1% Trifluoroacetic Acid (TFA)
- 0,1% Trifluoroacetic Acid (TFA)
- 0,1% Trifluoroacetic Acid (TFA)
- 0,1% Trifluoroacetic Acid (TFA)
- Molecular weight:
- 15,7/31,3 kDa
- 15,7/31,3 kDa
- 15,7/31,3 kDa
- 15,7/31,3 kDa
- 15,7/31,3 kDa
- Reconstitution instructions:
- Sterile water at 0,1 mg/ml
- Sterile water at 0,1 mg/ml
- Sterile water at 0,1 mg/ml
- Sterile water at 0,1 mg/ml
- Sterile water at 0,1 mg/ml
- Storage conditions:
- −20 °C
- −20 °C
- −20 °C
- −20 °C
- −20 °C
- Shipping temperature:
- RT
- RT
- RT
- RT
- RT
- Tested applications:
- Bioassay
- Bioassay
- Bioassay
- Bioassay
- Bioassay
Specifications
Product Family Options
Product Information
- Pack typePkAvailabilityPrice
- Specifications:
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Specifications
Cat. No.SHBT100-87-5UGProtein/peptide nameIL-17AProtein synonymsIL-17|CTLA-8Protein/peptide typeRecombinantProtein functionCytokineSpeciesHumanSourceE. coliConjugationUnconjugatedGene IDQ16552SequenceMIVKAGITIP RNPGCPNSED KNFPRTVMVN LNIHNRNTNT NPKRSSDYYN RSTSPWNLHR NEDPERYPSV IWEAKCRHLG CINADGNVDY HMNSVPIQQE ILVLRREPPH CPNSFRLEKI LVSVGCTCVT PIVHHVAProtease-freeNAnimal-freeNNuclease-freeNCarrier-freeYEndotoxin-freeNEndotoxin levelLowEndotoxin contentEndotoxin LAL (EU/µg) ≤0.1UniProtKBQ16552Biological activityBioactivity assay: Production of IL-6 from mouse 3T3 cells, ED50 ≤10 ng/ml, bioactivity ≥1,0×10⁵ units/mgPurity≥95%GradeRUOFormulation0,1% Trifluoroacetic Acid (TFA)Molecular weight15,7/31,3 kDaReconstitution instructionsSterile water at 0,1 mg/mlStorage conditions−20 °CShipping temperatureRTTested applicationsBioassay - Specifications:
More
Specifications
Cat. No.SHBT100-87-25UGProtein/peptide nameIL-17AProtein synonymsIL-17|CTLA-8Protein/peptide typeRecombinantProtein functionCytokineSpeciesHumanSourceE. coliConjugationUnconjugatedGene IDQ16552SequenceMIVKAGITIP RNPGCPNSED KNFPRTVMVN LNIHNRNTNT NPKRSSDYYN RSTSPWNLHR NEDPERYPSV IWEAKCRHLG CINADGNVDY HMNSVPIQQE ILVLRREPPH CPNSFRLEKI LVSVGCTCVT PIVHHVAProtease-freeNAnimal-freeNNuclease-freeNCarrier-freeYEndotoxin-freeNEndotoxin levelLowEndotoxin contentEndotoxin LAL (EU/µg) ≤0.1UniProtKBQ16552Biological activityBioactivity assay: Production of IL-6 from mouse 3T3 cells, ED50 ≤10 ng/ml, bioactivity ≥1,0×10⁵ units/mgPurity≥95%GradeRUOFormulation0,1% Trifluoroacetic Acid (TFA)Molecular weight15,7/31,3 kDaReconstitution instructionsSterile water at 0,1 mg/mlStorage conditions−20 °CShipping temperatureRTTested applicationsBioassay - Specifications:
More
Specifications
Cat. No.SHBT100-87-100UGProtein/peptide nameIL-17AProtein synonymsIL-17|CTLA-8Protein/peptide typeRecombinantProtein functionCytokineSpeciesHumanSourceE. coliConjugationUnconjugatedGene IDQ16552SequenceMIVKAGITIP RNPGCPNSED KNFPRTVMVN LNIHNRNTNT NPKRSSDYYN RSTSPWNLHR NEDPERYPSV IWEAKCRHLG CINADGNVDY HMNSVPIQQE ILVLRREPPH CPNSFRLEKI LVSVGCTCVT PIVHHVAProtease-freeNAnimal-freeNNuclease-freeNCarrier-freeYEndotoxin-freeNEndotoxin levelLowEndotoxin contentEndotoxin LAL (EU/µg) ≤0.1UniProtKBQ16552Biological activityBioactivity assay: Production of IL-6 from mouse 3T3 cells, ED50 ≤10 ng/ml, bioactivity ≥1,0×10⁵ units/mgPurity≥95%GradeRUOFormulation0,1% Trifluoroacetic Acid (TFA)Molecular weight15,7/31,3 kDaReconstitution instructionsSterile water at 0,1 mg/mlStorage conditions−20 °CShipping temperatureRTTested applicationsBioassay - Specifications:
More
Specifications
Cat. No.SHBT100-87-500UGProtein/peptide nameIL-17AProtein synonymsIL-17|CTLA-8Protein/peptide typeRecombinantProtein functionCytokineSpeciesHumanSourceE. coliConjugationUnconjugatedGene IDQ16552SequenceMIVKAGITIP RNPGCPNSED KNFPRTVMVN LNIHNRNTNT NPKRSSDYYN RSTSPWNLHR NEDPERYPSV IWEAKCRHLG CINADGNVDY HMNSVPIQQE ILVLRREPPH CPNSFRLEKI LVSVGCTCVT PIVHHVAProtease-freeNAnimal-freeNNuclease-freeNCarrier-freeYEndotoxin-freeNEndotoxin levelLowEndotoxin contentEndotoxin LAL (EU/µg) ≤0.1UniProtKBQ16552Biological activityBioactivity assay: Production of IL-6 from mouse 3T3 cells, ED50 ≤10 ng/ml, bioactivity ≥1,0×10⁵ units/mgPurity≥95%GradeRUOFormulation0,1% Trifluoroacetic Acid (TFA)Molecular weight15,7/31,3 kDaReconstitution instructionsSterile water at 0,1 mg/mlStorage conditions−20 °CShipping temperatureRTTested applicationsBioassay - Specifications:
More
Specifications
Cat. No.SHBT100-87-1MGProtein/peptide nameIL-17AProtein synonymsIL-17|CTLA-8Protein/peptide typeRecombinantProtein functionCytokineSpeciesHumanSourceE. coliConjugationUnconjugatedGene IDQ16552SequenceMIVKAGITIP RNPGCPNSED KNFPRTVMVN LNIHNRNTNT NPKRSSDYYN RSTSPWNLHR NEDPERYPSV IWEAKCRHLG CINADGNVDY HMNSVPIQQE ILVLRREPPH CPNSFRLEKI LVSVGCTCVT PIVHHVAProtease-freeNAnimal-freeNNuclease-freeNCarrier-freeYEndotoxin-freeNEndotoxin levelLowEndotoxin contentEndotoxin LAL (EU/µg) ≤0.1UniProtKBQ16552Biological activityBioactivity assay: Production of IL-6 from mouse 3T3 cells, ED50 ≤10 ng/ml, bioactivity ≥1,0×10⁵ units/mgPurity≥95%GradeRUOFormulation0,1% Trifluoroacetic Acid (TFA)Molecular weight15,7/31,3 kDaReconstitution instructionsSterile water at 0,1 mg/mlStorage conditions−20 °CShipping temperatureRTTested applicationsBioassay