Human Recombinant IL-1RA (from E. coli)
Supplier: Shenandoah Biotechnology
About this item
Interleukin-1 receptor antagonist (IL-1RA) binds the interleukin 1 receptor (IL-1R) to antagonize interleukin 1 alpha and beta signaling. IL-1RA is secreted by immune cells, epithelial cells, hepatocytes, and adipocytes to inhibit IL-1-induced inflammation. IL-1RA therapy is used to treat auto-inflammatory diseases such as diabetes and rheumatoid arthritis.
- High quality
- Low endotoxin
- Affordable
IL-1RA is secreted by immune cells, epithelial cells, hepatocytes, and adipocytes to inhibit IL-1-induced inflammation. IL-1RA therapy is used to treat auto-inflammatory diseases such as diabetes and rheumatoid arthritis.
: A COA is supplied with each product shipped detailing purity, formulation, biological activity, endotoxin levels, reconstitution instructions and recommended storage conditions.
: For research use only.
5 Options Available Below
Product Details & Documents
Interleukin-1 receptor antagonist (IL-1RA) binds the interleukin 1 receptor (IL-1R) to antagonize interleukin 1 alpha and beta signaling. IL-1RA is secreted by immune cells, epithelial cells, hepatocytes, and adipocytes to inhibit IL-1-induced inflammation. IL-1RA therapy is used to treat auto-inflammatory diseases such as diabetes and rheumatoid arthritis.
- High quality
- Low endotoxin
- Affordable
IL-1RA is secreted by immune cells, epithelial cells, hepatocytes, and adipocytes to inhibit IL-1-induced inflammation. IL-1RA therapy is used to treat auto-inflammatory diseases such as diabetes and rheumatoid arthritis.
: A COA is supplied with each product shipped detailing purity, formulation, biological activity, endotoxin levels, reconstitution instructions and recommended storage conditions.
: For research use only.
Specifications for Product Family
Specifications
Specifications
- Catalog No:
- SHBT100-195-20UG
- SHBT100-195-100UG
- SHBT100-195-250UG
- SHBT100-195-500UG
- SHBT100-195-1MG
- Protein/peptide name:
- IL-1RA
- IL-1RA
- IL-1RA
- IL-1RA
- IL-1RA
- Protein synonyms:
- IL-1F3|IL1RN
- IL-1F3|IL1RN
- IL-1F3|IL1RN
- IL-1F3|IL1RN
- IL-1F3|IL1RN
- Protein/peptide type:
- Recombinant
- Recombinant
- Recombinant
- Recombinant
- Recombinant
- Protein function:
- Cytokine
- Cytokine
- Cytokine
- Cytokine
- Cytokine
- Species:
- Human
- Human
- Human
- Human
- Human
- Source:
- E. coli
- E. coli
- E. coli
- E. coli
- E. coli
- Conjugation:
- Unconjugated
- Unconjugated
- Unconjugated
- Unconjugated
- Unconjugated
- Gene ID:
- P18510
- P18510
- P18510
- P18510
- P18510
- Sequence:
- MRPSGRKSSK MQAFRIWDVN QKTFYLRNNQ LVAGYLQGPN VNLEEKIDVV PIEPHALFLG IHGGKMCLSC VKSGDETRLQ LEAVNITDLS ENRKQDKRFA FIRSDSGPTT SFESAACPGW FLCTAMEADQ PVSLTNMPDE GVMVTKFYFQ EDE
- MRPSGRKSSK MQAFRIWDVN QKTFYLRNNQ LVAGYLQGPN VNLEEKIDVV PIEPHALFLG IHGGKMCLSC VKSGDETRLQ LEAVNITDLS ENRKQDKRFA FIRSDSGPTT SFESAACPGW FLCTAMEADQ PVSLTNMPDE GVMVTKFYFQ EDE
- MRPSGRKSSK MQAFRIWDVN QKTFYLRNNQ LVAGYLQGPN VNLEEKIDVV PIEPHALFLG IHGGKMCLSC VKSGDETRLQ LEAVNITDLS ENRKQDKRFA FIRSDSGPTT SFESAACPGW FLCTAMEADQ PVSLTNMPDE GVMVTKFYFQ EDE
- MRPSGRKSSK MQAFRIWDVN QKTFYLRNNQ LVAGYLQGPN VNLEEKIDVV PIEPHALFLG IHGGKMCLSC VKSGDETRLQ LEAVNITDLS ENRKQDKRFA FIRSDSGPTT SFESAACPGW FLCTAMEADQ PVSLTNMPDE GVMVTKFYFQ EDE
- MRPSGRKSSK MQAFRIWDVN QKTFYLRNNQ LVAGYLQGPN VNLEEKIDVV PIEPHALFLG IHGGKMCLSC VKSGDETRLQ LEAVNITDLS ENRKQDKRFA FIRSDSGPTT SFESAACPGW FLCTAMEADQ PVSLTNMPDE GVMVTKFYFQ EDE
- Protease-free:
- N
- N
- N
- N
- N
- Animal-free:
- N
- N
- N
- N
- N
- Nuclease-free:
- N
- N
- N
- N
- N
- Carrier-free:
- Y
- Y
- Y
- Y
- Y
- Endotoxin-free:
- N
- N
- N
- N
- N
- Endotoxin level:
- Low
- Low
- Low
- Low
- Low
- Endotoxin content:
- Endotoxin LAL (EU/µg) ≤1
- Endotoxin LAL (EU/µg) ≤1
- Endotoxin LAL (EU/µg) ≤1
- Endotoxin LAL (EU/µg) ≤1
- Endotoxin LAL (EU/µg) ≤1
- UniProtKB:
- P18510
- P18510
- P18510
- P18510
- P18510
- Biological activity:
- Bioactivity assay: Inhibition of human IL-1 alpha induced proliferation of D10,G4,1 cells, ED50 ≤50 ng/ml, bioactivity ≥2,0×10⁴ units/mg
- Bioactivity assay: Inhibition of human IL-1 alpha induced proliferation of D10,G4,1 cells, ED50 ≤50 ng/ml, bioactivity ≥2,0×10⁴ units/mg
- Bioactivity assay: Inhibition of human IL-1 alpha induced proliferation of D10,G4,1 cells, ED50 ≤50 ng/ml, bioactivity ≥2,0×10⁴ units/mg
- Bioactivity assay: Inhibition of human IL-1 alpha induced proliferation of D10,G4,1 cells, ED50 ≤50 ng/ml, bioactivity ≥2,0×10⁴ units/mg
- Bioactivity assay: Inhibition of human IL-1 alpha induced proliferation of D10,G4,1 cells, ED50 ≤50 ng/ml, bioactivity ≥2,0×10⁴ units/mg
- Purity:
- ≥95%
- ≥95%
- ≥95%
- ≥95%
- ≥95%
- Grade:
- RUO
- RUO
- RUO
- RUO
- RUO
- Formulation:
- 10 mM sodium phosphate, pH 7,5
- 10 mM sodium phosphate, pH 7,5
- 10 mM sodium phosphate, pH 7,5
- 10 mM sodium phosphate, pH 7,5
- 10 mM sodium phosphate, pH 7,5
- Molecular weight:
- 17,3 kDa
- 17,3 kDa
- 17,3 kDa
- 17,3 kDa
- 17,3 kDa
- Reconstitution instructions:
- Sterile water at 0,1 mg/ml
- Sterile water at 0,1 mg/ml
- Sterile water at 0,1 mg/ml
- Sterile water at 0,1 mg/ml
- Sterile water at 0,1 mg/ml
- Storage conditions:
- −20 °C
- −20 °C
- −20 °C
- −20 °C
- −20 °C
- Shipping temperature:
- RT
- RT
- RT
- RT
- RT
- Tested applications:
- Bioassay
- Bioassay
- Bioassay
- Bioassay
- Bioassay
Specifications
Product Family Options
Product Information
- Pack typePkAvailabilityPrice
- Specifications:
More
Specifications
Cat. No.SHBT100-195-20UGProtein/peptide nameIL-1RAProtein synonymsIL-1F3|IL1RNProtein/peptide typeRecombinantProtein functionCytokineSpeciesHumanSourceE. coliConjugationUnconjugatedGene IDP18510SequenceMRPSGRKSSK MQAFRIWDVN QKTFYLRNNQ LVAGYLQGPN VNLEEKIDVV PIEPHALFLG IHGGKMCLSC VKSGDETRLQ LEAVNITDLS ENRKQDKRFA FIRSDSGPTT SFESAACPGW FLCTAMEADQ PVSLTNMPDE GVMVTKFYFQ EDEProtease-freeNAnimal-freeNNuclease-freeNCarrier-freeYEndotoxin-freeNEndotoxin levelLowEndotoxin contentEndotoxin LAL (EU/µg) ≤1UniProtKBP18510Biological activityBioactivity assay: Inhibition of human IL-1 alpha induced proliferation of D10,G4,1 cells, ED50 ≤50 ng/ml, bioactivity ≥2,0×10⁴ units/mgPurity≥95%GradeRUOFormulation10 mM sodium phosphate, pH 7,5Molecular weight17,3 kDaReconstitution instructionsSterile water at 0,1 mg/mlStorage conditions−20 °CShipping temperatureRTTested applicationsBioassay - Specifications:
More
Specifications
Cat. No.SHBT100-195-100UGProtein/peptide nameIL-1RAProtein synonymsIL-1F3|IL1RNProtein/peptide typeRecombinantProtein functionCytokineSpeciesHumanSourceE. coliConjugationUnconjugatedGene IDP18510SequenceMRPSGRKSSK MQAFRIWDVN QKTFYLRNNQ LVAGYLQGPN VNLEEKIDVV PIEPHALFLG IHGGKMCLSC VKSGDETRLQ LEAVNITDLS ENRKQDKRFA FIRSDSGPTT SFESAACPGW FLCTAMEADQ PVSLTNMPDE GVMVTKFYFQ EDEProtease-freeNAnimal-freeNNuclease-freeNCarrier-freeYEndotoxin-freeNEndotoxin levelLowEndotoxin contentEndotoxin LAL (EU/µg) ≤1UniProtKBP18510Biological activityBioactivity assay: Inhibition of human IL-1 alpha induced proliferation of D10,G4,1 cells, ED50 ≤50 ng/ml, bioactivity ≥2,0×10⁴ units/mgPurity≥95%GradeRUOFormulation10 mM sodium phosphate, pH 7,5Molecular weight17,3 kDaReconstitution instructionsSterile water at 0,1 mg/mlStorage conditions−20 °CShipping temperatureRTTested applicationsBioassay - Specifications:
More
Specifications
Cat. No.SHBT100-195-250UGProtein/peptide nameIL-1RAProtein synonymsIL-1F3|IL1RNProtein/peptide typeRecombinantProtein functionCytokineSpeciesHumanSourceE. coliConjugationUnconjugatedGene IDP18510SequenceMRPSGRKSSK MQAFRIWDVN QKTFYLRNNQ LVAGYLQGPN VNLEEKIDVV PIEPHALFLG IHGGKMCLSC VKSGDETRLQ LEAVNITDLS ENRKQDKRFA FIRSDSGPTT SFESAACPGW FLCTAMEADQ PVSLTNMPDE GVMVTKFYFQ EDEProtease-freeNAnimal-freeNNuclease-freeNCarrier-freeYEndotoxin-freeNEndotoxin levelLowEndotoxin contentEndotoxin LAL (EU/µg) ≤1UniProtKBP18510Biological activityBioactivity assay: Inhibition of human IL-1 alpha induced proliferation of D10,G4,1 cells, ED50 ≤50 ng/ml, bioactivity ≥2,0×10⁴ units/mgPurity≥95%GradeRUOFormulation10 mM sodium phosphate, pH 7,5Molecular weight17,3 kDaReconstitution instructionsSterile water at 0,1 mg/mlStorage conditions−20 °CShipping temperatureRTTested applicationsBioassay - Specifications:
More
Specifications
Cat. No.SHBT100-195-500UGProtein/peptide nameIL-1RAProtein synonymsIL-1F3|IL1RNProtein/peptide typeRecombinantProtein functionCytokineSpeciesHumanSourceE. coliConjugationUnconjugatedGene IDP18510SequenceMRPSGRKSSK MQAFRIWDVN QKTFYLRNNQ LVAGYLQGPN VNLEEKIDVV PIEPHALFLG IHGGKMCLSC VKSGDETRLQ LEAVNITDLS ENRKQDKRFA FIRSDSGPTT SFESAACPGW FLCTAMEADQ PVSLTNMPDE GVMVTKFYFQ EDEProtease-freeNAnimal-freeNNuclease-freeNCarrier-freeYEndotoxin-freeNEndotoxin levelLowEndotoxin contentEndotoxin LAL (EU/µg) ≤1UniProtKBP18510Biological activityBioactivity assay: Inhibition of human IL-1 alpha induced proliferation of D10,G4,1 cells, ED50 ≤50 ng/ml, bioactivity ≥2,0×10⁴ units/mgPurity≥95%GradeRUOFormulation10 mM sodium phosphate, pH 7,5Molecular weight17,3 kDaReconstitution instructionsSterile water at 0,1 mg/mlStorage conditions−20 °CShipping temperatureRTTested applicationsBioassay - Specifications:
More
Specifications
Cat. No.SHBT100-195-1MGProtein/peptide nameIL-1RAProtein synonymsIL-1F3|IL1RNProtein/peptide typeRecombinantProtein functionCytokineSpeciesHumanSourceE. coliConjugationUnconjugatedGene IDP18510SequenceMRPSGRKSSK MQAFRIWDVN QKTFYLRNNQ LVAGYLQGPN VNLEEKIDVV PIEPHALFLG IHGGKMCLSC VKSGDETRLQ LEAVNITDLS ENRKQDKRFA FIRSDSGPTT SFESAACPGW FLCTAMEADQ PVSLTNMPDE GVMVTKFYFQ EDEProtease-freeNAnimal-freeNNuclease-freeNCarrier-freeYEndotoxin-freeNEndotoxin levelLowEndotoxin contentEndotoxin LAL (EU/µg) ≤1UniProtKBP18510Biological activityBioactivity assay: Inhibition of human IL-1 alpha induced proliferation of D10,G4,1 cells, ED50 ≤50 ng/ml, bioactivity ≥2,0×10⁴ units/mgPurity≥95%GradeRUOFormulation10 mM sodium phosphate, pH 7,5Molecular weight17,3 kDaReconstitution instructionsSterile water at 0,1 mg/mlStorage conditions−20 °CShipping temperatureRTTested applicationsBioassay