BIOARRAY™ terminal labelling kit with Biotin-ddUTP has been developed for DNA probe array assays.

This method uses Bio-ddUTP and terminal deoxynucleotide transferase to catalyse the addition of a single biotin-ddUMP to the 3'-OH terminus of an amplified and fragmented target DNA molecule. A standard reaction will label up to 100 picomoles (equivalent to 1 µg of a 30-nucleotide sequence). When DNA fragments are labelled at the 3'-OH terminus, the sequence bias that occurs with either nick translation or random priming is eliminated.