Specifications
- Pk:50 µG
- Protein/peptide type:Recombinant
- Source:E. coli
- Species:Human
- Tag sequence:His Tag
- Storage conditions:Stable for at least 1 year after receipt when stored at −20 °C. Working aliquots are stable for up to 3 months when stored at −20 °C.
- Protein synonyms:Interleukin-21
- Protein/peptide name:IL-21 mutant
- Purity:>90% (SDS-PAGE)
- Sequence:32-162
- Formulation:Lyophilized from 0.2um-filtered solution in PBS.
Specifications
About this item
Interleukin-21 (IL-21) is a key factor in the transition between innate and adaptive immune responses secreted by activated T cells. The IL-21 receptor (IL-21R) is expressed in lymphoid tissue, in particular by NK, B, T and dendritic cells, macrophages and endothelial cells. Recent evidence suggests that IL-21 plays a supportive role in the proliferation of T and B cells and influences the cytolytic activity of natural killer cells. IL-21 has been shown to up-regulate genes associated with innate immunity and to inhibit the differentiation of naive T helper cells. IL-21 specifically inhibits IFN-gamma production from developing TH1 cells and is preferentially expressed by TH2 cells. Furthermore IL-21 has been identified as a growth and survival factor for human myeloma cells. IL-21/IL-21R interactions have a unique role in sequentially activating both innate and adaptive immune responses against poorly immunogenic tumours, leading to tumour rejection that is perforin dependent but IFN-gamma independent.
Fusion-Tag: His Tag
This recombinant proteins is for research use only.