Mouse recombinant IL-2 non-lytic (from NS1 cells)
PRSI90-468
:
- Pk:10 µG
- Protein/peptide type:Recombinant
- Source:NS1 cells
- Species:Mouse
- Environmentally Preferable:
- Tag sequence:Fc Tag
- Storage conditions:Stable for at least 1 year after receipt when stored at −20 °C. Working aliquots are stable for up to 3 months when stored at −20 °C.
- Biological activity:Specific Activity: 1-1.5 x106 Units/mg, measured using CTLL indicator cells.
Shows the biological function of the IL-2 moiety and exerts a prolonged circulating half-life caused by the modified Fc domain. Blocks diabetogenic autoimmunity in nonobese diabetic mice. - Protein synonyms:Interleukin-2|Aldesleukin
- Protein/peptide name:IL-2 non-lytic
- Purity:>98% (SDS-PAGE)
- Sequence:21-169
- Formulation:Lyophilized from 0.2um-filtered solution in PBS.
Interleukin-2 (IL-2) is a 133 amino acid glycoprotein with one intramolecular disulfide bond and variable glycosylation. It is secreted by activated T cells and induces proliferation and maturation of activated T cells, natural killer cells, and lymphokine activated killer cells. IL-2 also stimulates proliferation of antibody-producing B cells, activates neutrophils, and induces mononuclear cells to secrete IFN-gamma and TNF-alpha and -beta. Moreover, studies have shown that IL-2 is required for activation-induced apoptosis, an important hemeostatic mechanism in the immune system, which is involved in the maintenance of peripheral tolerance to self-antigens.
Fusion-Tag: Fc Tag
This recombinant proteins is for research use only.