Specifications
- Pk:100 µG
- Protein/peptide type:Recombinant
- Source:CHO cells
- Species:Human
- Tag sequence:Fc Tag
- Storage conditions:Stable for at least 1 year after receipt when stored at −20 °C. Working aliquots are stable for up to 3 months when stored at −20 °C.
- Protein synonyms:Tumor Necrosis Factor Receptor Superfamily Member 6B|TNFRSF6B|Decoy Receptor 3|M68
- Protein/peptide name:DcR3
- Purity:>98% (SDS-PAGE)
- Sequence:24-300
- Formulation:Lyophilized from 0.2um-filtered solution in PBS.
Specifications
About this item
Decoy receptor 3 (DcR3; TNFRSF6B; M68) is a member of the TNF receptor superfamily. DcR3 shares sequence identity with OPG (31%), TNF-RII (29%) and Fas (17%) and is expressed in a variety of different tissues and at high levels in many malignant tumours. Ligands of DcR3 include Fas ligand, homologous to lymphotoxin showing inducible expression and competing with HSV glycoprotein D for herpes virus entry mediator (a receptor expressed by T lymphocytes), TNF-like molecule 1A and heparan sulfate proteoglycans. DcR3 modulates the function of T cells, dendritic cells and macrophages. DcR3/Fc fusion proteins can bind to human and mouse B cells and suppress the activation of B cells.
Fusion-Tag: Fc Tag
This recombinant proteins is for research use only.