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Human recombinant FGF23 (from HEK293 cells)
Human recombinant FGF23 (from HEK293 cells)
  PRSI90-116
 :  ProSci Inc.
 :  
Human recombinant FGF23 (from HEK293 cells)
  PRSI90-116
 :  ProSci Inc.
 :  

 

  • Pk:
    50 µG
  • Protein/peptide type:
    Recombinant
  • Source:
    HEK293 cells
  • Species:
    Human
  • Tag sequence:
    Fc Tag
  • Storage conditions:
    Working aliquots are stable for up to 3 months when stored at −20 °C.
  • Biological activity:
    Activates ERK and FRS2alpha phosphorylation in Klotho expressing cells.
  • Protein synonyms:
    Tumor-derived Hypophosphatemia-inducing Factor|Fibroblast Growth Factor 23
  • Protein/peptide name:
    FGF23
  • Purity:
    >90% (SDS-PAGE)
  • Sequence:
    1-251
  • Formulation:
    0.2um-filtered solution in PBS.

 

 

FGF-23 (Fibroblast growth factor 23) is a regulator of phosphate homeostasis. It upregulates EGR1 expression in the presence of KLBy. Acts directly on the parathyroid to decrease PTH secretion. Regulates the vitamin-D metabolism. Negatively regulates osteoblast differentiation and matrix mineralisation. Defects in FGF-23 are the cause of autosomal dominant hypophosphataemic rickets (ADHR) and of hyperphosphatemic familial tumoral calcinosis (HFTC).

Fusion-Tag: Fc Tag

This recombinant proteins is for research use only.