Human recombinant HTRA2 (from cells)
Catalog # PRSI91-602
Supplier: ProSci Inc.
CAS Number:
Specifications
- Pk:50 µG
- Protein/peptide type:Recombinant
- Source:Cells
- Species:Human
- Tag sequence:C-6 His tag
- Storage conditions:Store at −20 °C, stable for 6 months after receipt. Please minimize freeze-thaw cycles.
- Protein synonyms:Omi stress-regulated endoprotease|Serine proteinase OMI|mitochondrial|Serine protease HTRA2|Serine protease 25|OMI|HtrA2|PRSS25|High temperature requirement protein A2
- Protein/peptide name:HTRA2
- Purity:> 95% as determined by reducing SDS-PAGE
- Molecular weight:36 kD
- Sequence:Ala134-Glu458
- Formulation:Supplied as a 0.2 um filtered solution of 20mM Tris,150mM NaCl,pH7.5. Always centrifuge tubes before opening. Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100 ug/ml. Dissolve the lyophilized protein in ddH2O. Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
- Tested applications:Bioassay
Specifications
About this item
High temperature requirement protein A2(HTRA2) is a single-pass membrane protein .It contains 1 PDZ (DHR) domain and belongs to the peptidase S1C family. HtrA2 can be released from the mitochondria during apoptosis and uses its four most N-terminal amino acids to mimic a caspase and be recruited by IAP caspase inhibitors such as XIAP and CIAP1/2. It promotes or induces cell death either by direct binding to and inhibition of BIRC proteins (also called inhibitor of apoptosis proteins, IAPs), leading to an increase in caspase activity, or by a BIRC inhibition-independent, caspase-independent and serine protease activity-dependent mechanism. The protein cleaves THAP5 and promotes its degradation during apoptosis.
- This recombinant protein can be used for biological assays. For research use only.
Fusion-Tag: C-6 His tag