Human recombinant Gankyrin (from E. coli)
PRSI91-146
:
- Pk:50 µG
- Protein/peptide type:Recombinant
- Source:E. coli
- Species:Human
- Environmentally Preferable:
- Storage conditions:Store at −20 °C, stable for 6 months after receipt. Please minimize freeze-thaw cycles.
- Protein synonyms:PSMD10|Gankyrin|26S Proteasome Non-ATPase Regulatory Subunit 10|26S Proteasome Regulatory Subunit p28|p28(GANK)
- Protein/peptide name:Gankyrin
- Purity:> 95% as determined by reducing SDS-PAGE
- Molecular weight:24.43 kD
- Sequence:Met1-Gly226
- Formulation:Supplied as a 0.2 um filtered solution of 20mM PB, 150mM NaCl, 10% Glycerol, pH 7.4. Always centrifuge tubes before opening. Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100 ug/ml. Dissolve the lyophilized protein in ddH2O. Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
- Tested applications:For Biological assays
Gankyrin is a multicatalytic proteinase oncoprotein consists of 7 ankyrin repeats. Gankyrin overexpressed in most hepatocellular carcinomas. Gankyrin is involved in theregulation of the phosphorylation of the retinoblastoma protein by CDK4 to enhance the ubiquitinylation of p53 by MDM2. Gankyrin is also involved in progression of esophageal squamous cell carcinoma. Gankyrin plays an oncogenic role especially in early stages of human epatocarcinogenesis.
- This recombinant protein can be used for biological assays. For research use only.