Human recombinant IL17A (from E. coli)
Catalog # PRSI40-521
Supplier: ProSci Inc.
CAS Number:
Specifications
- Pk:25 µG
- Protein/peptide type:Recombinant
- Source:E. coli
- Species:Human
- Biological activity:Assay 1: Determined by the dose-dependent induction of IL-6 in primary human foreskin fibroblast. The expected ED50is ≤ 2.0 ng/mL, corresponding to a specific activity of ≥ 5 x 105 units/mg.
Assay 2: Measured by its ability to induce IL-6 production by NHDF cells. - Protein synonyms:IL-17|IL17|CTLA8|IL-17A|Interleukin-17A|Cytotoxic T-lymphocyte-associated antigen 8
- Protein/peptide name:IL17A
- Purity:>98%
- Formulation:Lyophilized
Specifications
About this item
Human IL-17A is a homodimer of two 136 amino acid chains, secreted by activated T-cells that act on stromal cells to induce production of proinflammatory and hematopoietic bioactive molecules. Today, IL-17 represents a family of structurally-related cytokines that share a highly conserved C-terminal region but differ from one another in their N-terminal regions and in their distinct biological roles. The six known members of this family, IL-17A through IL-17F, are secreted as homodimers. IL-17A exhibits cross-species bioactivity between human and murine cells. Recombinant human IL-17A is a 31.0 kDa disulfide-linked homodimer of two 136 amino acid polypeptide chains.
- Murine IL-17A is a disulfide linked homodimer, secreted by activated T-cells that act on stromal cells to induce production of proinflammatory and hematopoietic bioactive molecules. Today, IL-17 represents a family of structurally-related cytokines that share a highly conserved C-terminal region but differ from one another in their N-terminal regions and in their distinct biological roles. The six known members of this family, IL-17A through IL-17F, are secreted as homodimers. IL-17A exhibits cross-species bioactivity between human and murine cells. Recombinant murine IL-17A is a 30.0 kDa disulfide-linked homodimer of two 133 amino acid polypeptide chains.
Store in working aliquots at -20°C. Avoid freeze/thaw cycles.