Anti-DDX58 Mouse Monoclonal Antibody (Biotin) [clone: Alme-1]
Catalog # PRSI36-103
Supplier: ProSci Inc.
Specifications
- Antibody type:Primary
- Antigen name:DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
- Antigen symbol:DDX58
- Clonality:Monoclonal
- Clone:Alme-1
- Conjugation:Biotin
- Host:Mouse
- ImmunoChemistry:Yes
- ImmunoPrecipitation:Yes
- Isotype:IgG1
- Reactivity:Human,Mouse
- Western blot:Yes
- Form:Liquid
- Gene ID:23586
- Antigen synonyms:Probable ATP-dependent RNA Helicase DDX58|DEAD-box Protein 58|RIG-1|Retinoic Acid-inducible Gene 1 Protein
- Storage buffer:In PBS containing 0.02% sodium azide.
- Storage temperature:Stable for at least 1 year after receipt when stored at -20˚C.
- Concentration:0.5 mg/ml
- Shipping temperature:-20°C
- Immunogen:Recombinant human RIG-I (aa 201-713).
- Purification:>95% (SDS-PAGE)
- Size:100 μg
- Pk:100 µG
Specifications
About this item
RIG-I and MDA5 are highly conserved helicases involved in the innate immune response to virus. RIG-I is a member of the DEAD-box RNA helicases and is activated by cytoplasmic dsRNA and 5’-ppp RNA produced during the viral replication. The protein is characterized by a N-terminal region with two caspase recruitment domains (CARD) and a C-terminal region harboring potential ATP-dependent RNA helicase activity. RIG-I recruits the CARD adaptor inducing IFN-beta (Cardif) in a CARD-CARD-dependent manner resulting in NF-kappaB and IRF3 activation.
Type: Primary
Antigen: DDX58
Clonality: Monoclonal
Clone: Alme-1
Conjugation: Biotin
Epitope:
Host: Mouse
Isotype: IgG1
Reactivity: Human, Mouse