7-Ethyl-10-hydroxycamptothecin ≥98%
SN-38 is the active metabolite of irinotecan, a derivative of the alkaloid camptothecin and acts as a potent inhibitor of DNA topoisomerase I. SN-38 is a more potent topopisomerase I inhibitor and more cytotoxic to HT-29 colon cancer cells (IC50 = 8.8 nM) compared to irinotecan (IC50 >100 nM).
- SN-38 is in a form of crystalline solid
- λmax at 224, 267, 331, 368, 383 nm
: 10-hydroxy-7-ethylcamptothecin, (S)-4,11-Diethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione, 7-Ethyl-10-hydroxy-20(S)-Camptothecin, SN-38, NK 012
- :86639-52-3
- :C₂₂H₂₀N₂O₅
- :MFCD00871873
- :392.40 g/mol
- :Freezer
- :2811
- :6.1,III
SN-38 is the active metabolite of irinotecan, a derivative of the alkaloid camptothecin and acts as a potent inhibitor of DNA topoisomerase I. SN-38 is a more potent topopisomerase I inhibitor and more cytotoxic to HT-29 colon cancer cells (IC50 = 8.8 nM) compared to irinotecan (IC50 >100 nM).
- SN-38 is in a form of crystalline solid
- λmax at 224, 267, 331, 368, 383 nm
: 10-hydroxy-7-ethylcamptothecin, (S)-4,11-Diethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione, 7-Ethyl-10-hydroxy-20(S)-Camptothecin, SN-38, NK 012
- :86639-52-3
- :C₂₂H₂₀N₂O₅
- :MFCD00871873
- :392.40 g/mol
- :Freezer
- :2811
- :6.1,III
Product Family Options
- Pk