Recognizes a 53 kDa protein, which is identified as p53 suppressor gene product. It reacts with the mutant as well as the wild form of p53 under denaturing and non-denaturing conditions. Its epitope maps within the N-terminus (aa 20-25) of p53 oncoprotein. p53 is a tumor suppressor gene expressed in a wide variety of tissue types and is involved in regulating cell growth, replication, and apoptosis. It binds to MDM2, SV40 T antigen and human papilloma virus E6 protein. Positive nuclear staining with p53 antibody has been reported to be a negative prognostic factor in breast carcinoma, lung carcinoma, colorectal, and urothelial carcinoma. Anti-p53 positivity has also been used to differentiate uterine serous carcinoma from endometrioid carcinoma as well as to detect intratubular germ cell neoplasia. Mutations involving p53 are found in a wide variety of malignant tumors, including breast, ovarian, bladder, colon, lung, and melanoma.
Type: Primary
Antigen: TP53
Clonality: Monoclonal
Clone: BP53-12 DO-7
Conjugation: CF488A
Epitope:
Host: Mouse
Isotype: IgGs
Reactivity: Cow, Human, Monkey
- Catalog No:
- BNC880723-500
- BNC880723-100
- Antigen symbol:
- TP53
- TP53
- Antigen name:
- p53
- p53
- Antigen synonyms:
- Transformation Related Protein 53 (TRP53)|Tumor Protein p53|BCC7|Cellular Tumor Antigen p53|Tumor Suppressor p53|TP53|LFS1|Antigen NY-CO-13
- Transformation Related Protein 53 (TRP53)|Tumor Protein p53|BCC7|Cellular Tumor Antigen p53|Tumor Suppressor p53|TP53|LFS1|Antigen NY-CO-13
- Antibody type:
- Primary
- Primary
- Clonality:
- Monoclonal
- Monoclonal
- Conjugation:
- CF® 488A
- CF® 488A
- Clone:
- Clone BP53-12 DO-7
- Clone BP53-12 DO-7
- Reactivity:
- Monkey, Human, Bovine
- Monkey, Human, Bovine
- Host:
- Mouse
- Mouse
- Gene ID:
- 654481
- 654481
- Isotype:
- IgGs
- IgGs
- Western blot:
- Yes
- Yes
- ImmunoChemistry:
- Yes
- Yes
- ImmunoFluorescence:
- Yes
- Concentration:
- 0,1 mg/ml
- 0,1 mg/ml
- Storage buffer:
- PBS/0,1% BSA/0,05% azide
- PBS/0,1% BSA/0,05% azide