- Antibody type:Primary
- Antigen name:Cytokeratin HMW
- Antigen symbol:KRT76
- Clonality:Monoclonal
- Clone:Clone AE-3
- Conjugation:Unconjugated
- Host:Mouse
- ImmunoChemistry:Yes
- ImmunoFluorescence:Yes
- Isotype:IgG1 kappa
- Reactivity:Rabbit,Monkey,Chicken,Human,Bovine,Dog,Rat,Mouse
- Western blot:Yes
- Gene ID:654392
- Antigen synonyms:Keratin|Type-II Keratin Kb9|KRT2P|Cytokeratin-2P (CK-2P|Keratin 2p (K2P)|type II Cytoskeletal 2 oral|HUMCYT2A|K76|Keratin-76|KRT2B
- Storage buffer:PBS/0,05% azide
- Concentration:1 mg/mL
- Purification:BSA-free
- Size:50 μL
- Pk:50 µl
This MAb recognizes basic (Type II or HMW) cytokeratins, which include 67 kDa (CK1); 64 kDa (CK3); 59 kDa (CK4); 58 kDa (CK5); 56 kDa (CK6); 52 kDa (CK8). Twenty human keratins are resolved with two-dimensional gel electrophoresis into acidic (pI 6.0) subfamilies. The acidic keratins have molecular weights (MW) of 56.5, 55, 51, 50, 50 , 48, 46, 45, and 40 kDa. MAb AE3 recognizes the 65-67, 64, 59, 58, 56, and 52 kDa keratins of basic subfamily. Many studies have shown the usefulness of keratins as markers in cancer research and tumor diagnosis. AE1/AE3 is a broad spectrum anti pan-keratin antibody cocktail, which differentiates epithelial tumors from non-epithelial tumors e.g. squamous vs. adenocarcinoma of the lung, liver carcinoma, breast cancer, and esophageal cancer.
Type: Primary
Antigen: KRT76
Clonality: Monoclonal
Clone: AE-3
Conjugation: Purified, BSA-free
Epitope:
Host: Mouse
Isotype: IgG1 kappa
Reactivity: Chicken, Cow, Dog, Human, Monkey, Mouse, Rabbit, Rat