About this item
This MAb recognizes the 56.5 kDa (CK10); 50 kDa (CK14); 50 kDa (CK15); 48 kDa (CK16); 40 kDa (CK19) keratins of the acidic (Type I or LMW) subfamily. Twenty human keratins are resolved with two-dimensional gel electrophoresis into acidic (pI 6.0) subfamilies. The acidic keratins have molecular weights (MW) of 56.5, 55, 51, 50, 50', 48, 46, 45, and 40 kDa. MAb AE3 recognizes the 65-67, 64, 59, 58, 56, and 52 kDa keratins of basic subfamily. Many studies have shown the usefulness of keratins as markers in cancer research and tumor diagnosis. AE1/AE3 is a broad spectrum anti pan-keratin antibody cocktail, which differentiates epithelial tumors from non-epithelial tumors e.g. squamous vs. adenocarcinoma of the lung, liver carcinoma, breast cancer, and esophageal cancer.
Type: Primary
Antigen: KRT77
Clonality: Monoclonal
Clone: AE-1
Conjugation: CF647
Epitope:
Host: Mouse
Isotype: IgG1 kappa
Reactivity: Chicken, Cow, Dog, Human, Monkey, Mouse, Rabbit, Rat, Turtle
Specifications
- Catalog No:
- BNC470253-100
- BNC470253-500
- Antigen symbol:
- KRT77
- KRT77
- Antigen name:
- Cytokeratin LMW
- Cytokeratin LMW
- Antigen synonyms:
- K77|Keratin|KRT1B|Type-II Keratin Kb39|Keratin-77|type II cytoskeletal 1b|K1B|CK-1B|Keratin 1B|Cytokeratin-1B
- K77|Keratin|KRT1B|Type-II Keratin Kb39|Keratin-77|type II cytoskeletal 1b|K1B|CK-1B|Keratin 1B|Cytokeratin-1B
- Antibody type:
- Primary
- Primary
- Clonality:
- Monoclonal
- Monoclonal
- Conjugation:
- CF® 647
- CF® 647
- Clone:
- Clone AE-1
- Clone AE-1
- Reactivity:
- Turtle, Rabbit, Monkey, Chicken, Human, Bovine, Dog, Rat, Mouse
- Turtle, Rabbit, Monkey, Chicken, Human, Bovine, Dog, Rat, Mouse
- Host:
- Mouse
- Mouse
- Gene ID:
- 334989
- 334989
- Isotype:
- IgG1 kappa
- IgG1 kappa
- Western blot:
- Yes
- Yes
- ImmunoChemistry:
- Yes
- Yes
- ImmunoFluorescence:
- Yes
- Yes
- Concentration:
- 0,1 mg/ml
- 0,1 mg/ml
- Storage buffer:
- PBS/0,1% BSA/0,05% azide
- PBS/0,1% BSA/0,05% azide