Recognizes a protein of 80 kDa-90 kDa, identified as CD36 (Workshop IV; Code P-26). Its epitope maps between aa155-183. It is expressed on platelets, monocytes and macrophages, microvascular endothelial cells, erythrocyte precursors, mammary epithelial cells, and some macrophage derived dendritic cells. CD36 acts as a receptor for thrombospondin (TSP), collagen types I, IV and V, P. falciparum malaria-infected erythrocytes, and sickle erythrocytes. It also functions as a scavenger receptor, mediating macrophage uptake of oxidized low-density lipoprotein (LDL) and recognition of apoptotic polymorphonuclear leukocytes (PMN). CD36 plays a role in platelet aggregation, macrophage foam cell development, inflammation, and the tissue ischemia observed in sickle cell disease and cerebral malaria. Note that 1-4% of Japanese and East Asia population lack CD36. This MAb blocks adhesion of P. falciparum parasitized red blood cells to CD36 and strongly inhibits collagen-induced platelet aggregation.
Type: Primary
Antigen: CD36
Clonality: Monoclonal
Clone: 185-1G2
Conjugation: CF405S
Epitope:
Host: Mouse
Isotype: IgG2a kappa
Reactivity: Human
- Catalog No:
- BNC040169-500
- BNC040169-100
- Antigen symbol:
- CD36
- CD36
- Antibody type:
- Primary
- Primary
- Clonality:
- Monoclonal
- Monoclonal
- Conjugation:
- CF® 405S
- CF® 405S
- Clone:
- Clone 185-1G2
- Clone 185-1G2
- Reactivity:
- Human
- Human
- Host:
- Mouse
- Mouse
- Gene ID:
- 120949
- 120949
- Isotype:
- IgG2a kappa
- IgG2a kappa
- ImmunoFluorescence:
- Yes
- Concentration:
- 0,1 mg/ml
- 0,1 mg/ml
- Storage buffer:
- PBS/0,1% BSA/0,05% azide
- PBS/0,1% BSA/0,05% azide