Imject® Maleimide-activated mcKLH and PEGylated mcKLH enable conjugation of sulfhydryl-containing peptide haptens to elicit an immune response and antibody production against the hapten.

• Used to achieve the highest antigen conjugation efficiency
• Cysteine reactive chemistry enables controlled orientation of your antigen
• High solubility minimises loss during conjugation

The mcKLH is maleimide-activated using a heterobifunctional crosslinker that contains an N-hydroxysuccinimide (NHS) ester and a maleimide group. The PEGylated mcKLH is activated with NHS-PEG₂-Maleimide, creating a more soluble maleimideactivated mcKLH. Maleimide groups react with free sulfhydryls, forming stable thioether bonds.