Specifications
- Antibody type:Primary
- Antigen name:DnaJ Hsp40 homolog, subfamily A, member 1
- Antigen symbol:HSP 40-4/HDJ2/DNAJA1
- Clonality:Polyclonal
- Conjugation:Unconjugated
- Host:Rabbit
- ImmunoChemistry:Yes
- Isotype:IgG
- Reactivity:Human,Rat,Mouse
- Western blot:Yes
- Form:liquid
- Antigen synonyms:subfamily A|HDJ-2|DJ 2|DNAJ2|Heat shock 40 kDa protein 4|heat shock protein DNAJ like 2|OTTHUMP00000021193.|HSJ-2|Heat shock protein J2|HSPF4|DNJA1_HUMAN|DjA1|HDJ2|Neural precursor cell expressed developmentally down regulated 7|DJ2|HSDJ|member 1|NEDD7|HSJ2|hDJ 2|DnaJ protein homolog 2|DnaJ Hsp40 homolog|Human DnaJ protein 2|DnaJ homolog subfamily A member 1|Dnaja1
- Storage buffer:Aqueous buffered solution containing 100ug/ml BSA, 50% glycerol and 0,09% sodium azide. Store at -20°C for 12 months.
- Concentration:1 ug/ul
- Shipping temperature:4 °C
- Purification:Purified by Protein A.
- Size:100 μg
- Pk:100 µl
Specifications
About this item
DnaJ-like proteins interact with HSP 70 molecular chaperones and function to facilitate protein folding and mitochondrial protein import. HSP 40-4, also known as HDJ2, is the human DnaJ homolog that functions as a co-chaperone with a cysteine-rich zinc finger domain. The cellular redox enzyme thioredoxin interacts with HSP 40-4, and oxidation and reduction reversibly regulate HSP 40-4 function in response to the changing redox states of the cell. The zinc finger domain of HSP 40-4 may act as a redox sensor of chaperone-mediated protein-folding machinery, since HSP 40-4 inactivation leads to the oxidation of cysteine thiols and a simultaneous release of coordinated zinc. Loss of the HSP 40-4 protein may be linked to severe defects in spermatogenesis that involve aberrant androgen signaling.
WB(1:100-1000), IHC-P(1:100-500), IF(IHC-P)(1:50-200)
Type: Primary
Antigen: HSP 40-4/HDJ2/DNAJA1
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: Human, Mouse, Rat