PL Cl-Trt-Cl supports peptide synthesis using the Fmoc approach. This resin can be used for the synthesis of a wide range of organic acids, and has also been used for the synthesis of amines, phenols and other alcohols.

It benefits from ease of attachment of the first amino acid residue and was originally designed as a particularly acid-sensitive resin for the production of fully protected peptide fragments. In this mode, cleavage of peptides can be accomplished by very mild acidolysis, leaving any tert-butyl side chain protection intact. This enables the isolation and subsequent assembly of protected fragments to produce much larger peptides.