PYR-41

Supplier: Apollo Scientific

PYR-41

Supplier: Abcam

Ubiquitin-activating enzyme (E1) inhibitor (IC₅₀ =5 μM). Inhibits ubiquitination and proteasomal degradation. Additionally increases sumoylation of proteins and induces p53-mediated apoptosis.

Supplier: Thermo Fisher Scientific

PYR-41 is a cell permeable inhibitor of Ubiquitin activating enzyme (E1) with little or no activity against E3, E2, or caspase enzymatic activity.