- Antibody type:Primary
- Antigen name:TRPM8
- Clonality:Polyclonal
- Conjugation:Alexa Fluor® 680
- Host:Rabbit
- ImmunoChemistry:Yes
- ImmunoFluorescence:Yes
- Isotype:IgG
- Reactivity:Human,Rat,Mouse
- Western blot:Yes
- Environmentally Preferable:
- Epitope:81-180/1104
- Form:Liquid
- Gene ID:79054
- Antigen synonyms:Trp p8|Trpm8|Transient receptor potential cation channel subfamily M member 8|Transient receptor potential p8|TRPP8|LTrpC6 antibody Short form of the TRPM8 cationic channel|transient receptor potential-p8|MGC2849|LTrpC-6|TRPM8_HUMAN|Long transient receptor potential channel 6|Trp-p8
- Modification:Unmodified
- Storage buffer:Aqueous buffered solution containing 0,01 M TBS (pH 7,4) with 1% BSA, 0,03% Proclin300 and 50% Glycerol
- Storage temperature:Store at ‒20 °C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
- Concentration:1 µg/µl
- Shipping temperature:4 °C
- Immunogen:KLH conjugated synthetic peptide derived from human TRPM8
- Purification:Purified by Protein A
- Pack type:Vial
- Pk:100 µl
Receptor-activated non-selective cation channel involved in detection of sensations such as coolness, by being activated by cold temperature below 25 degrees Celsius. Activated by icilin, eucalyptol, menthol, cold and modulation of intracellular pH. Involved in menthol sensation. Permeable for monovalent cations sodium, potassium, and cesium and divalent cation calcium. Temperature sensing is tightly linked to voltage-dependent gating. Activated upon depolarisation, changes in temperature resulting in graded shifts of its voltage-dependent activation curves. The chemical agonists menthol functions as a gating modifier, shifting activation curves towards physiological membrane potentials. Temperature sensitivity arises from a tenfold difference in the activation energies associated with voltage-dependent opening and closing.
Type: Primary
Antigen: TRPM8
Clonality: Polyclonal
Clone:
Conjugation: ALEXA FLUOR® 680
Public Immunogen Range: 81-180/1104
Host: Rabbit
Isotype: IgG
Reactivity: Human; Mouse; Rat