You searched for: Proteins and Peptides
Proteins are used in routine laboratory procedures such as binding enzymes or coupling peptides to carrier proteins. These kits, mixture solutions, and collagen matrices fulfill a myriad of essential laboratory functions for developing relationships between proteins and other cellular components. The stimulating proteins offered have various amino acid arrangements and functions to fulfill any sample manipulation for testing purposes in any field.
Human recombinant integrin alpha V beta 8 (from HEK293)
Supplier: ACRO Biosystems
Human recombinant integrin alpha V beta 8 (from HEK293)
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Human recombinant integrin alpha V beta 8 (from HEK293)
Supplier: ACRO Biosystems
Human recombinant integrin alpha V beta 8 (from HEK293)
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Human recombinant IgG1 Fc (from HEK293 cells)
Supplier: ACRO Biosystems
Human recombinant IgG1 Fc (from HEK293 cells)
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Human recombinant CD30 ligand (from HEK293)
Supplier: ACRO Biosystems
Human recombinant CD30 ligand (from HEK293)
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Human recombinant VEGF R3 (from HEK293)
Supplier: ACRO Biosystems
Human recombinant VEGF R3 (from HEK293)
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Human recombinant MIS RII (from HEK293 cells)
Supplier: ACRO Biosystems
Human recombinant MIS RII (from HEK293 cells)
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Human recombinant Glypican 3 (from HEK293), Acro Biosystems
Supplier: ACRO Biosystems
Human recombinant Glypican 3 (from HEK293), Acro Biosystems
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Human recombinant integrin alpha 2b beta 3 (from HEK293)
Supplier: ACRO Biosystems
Human recombinant integrin alpha 2b beta 3 (from HEK293)
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Cynomolgus recombinant Fc gamma RIII / CD16 (from HEK293)
Supplier: ACRO Biosystems
Cynomolgus recombinant Fc gamma RIII / CD16 (from HEK293)
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Annexin V, APC
Supplier: STEMCELL Technologies
A cellular protein for detection of apoptotic cells, APC-conjugated.
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Human recombinant NRG1 Beta 1 (from HEK293 cells)
Supplier: ACRO Biosystems
Human NRG1 Beta 1 Protein, Fc Tag.
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Mouse recombinant CD8 alpha (from HEK293 cells), biotin
Supplier: ACRO Biosystems
Mouse recombinant CD8 alpha (from HEK293 cells), biotin
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Mouse recombinant Siglec-15 (from HEK293 cells)
Supplier: ACRO Biosystems
Mouse recombinant Siglec-15 (from HEK293 cells)
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Human recombinant Fc gamma RIIB/ CD32b (from HEK293 cells)
Supplier: ACRO Biosystems
Human recombinant Fc gamma RIIB/ CD32b (from HEK293 cells)
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Human recombinant FAP (from HEK293 cells), FITC (Fluorescein Isothiocyanate)
Supplier: ACRO Biosystems
Human recombinant FAP (from HEK293 cells), FITC (Fluorescein Isothiocyanate)
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Human recombinant IL-1 RAcP (from HEK293 cells), Fc Tag
Supplier: ACRO Biosystems
Human recombinant IL-1 RAcP (from HEK293 cells), Fc Tag
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Human recombinant siglec-15 (from HEK293 cells)
Supplier: ACRO Biosystems
Human Siglec-15 / CD33L3 Protein, Mouse IgG2a Fc Tag.
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Human transferrin (from Orzya sativa)
Supplier: Biorbyt
Recombinant human transferrin produced in plant is non-glycosylated, polypeptide chain containing 679 amino acids.
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Cynomolgus monkey recombinant Fc gamma RIIA/CD32a (from HEK293 cells)
Supplier: ACRO Biosystems
Cynomolgus Fc gamma RIIA / CD32a Protein, His Tag (SPR & BLI & HPLC verified).
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Influenza (HLA Class I Control) Peptide Pool
Supplier: STEMCELL Technologies
Influenza (HLA class I control) peptide pool is a lyophilised mixture of 17 peptides from the influenza virus. The pool consists of defined HLA class I-restricted T cell epitopes, and can be used as an antigen-specific positive control to stimulate T cells.
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CMV (pp65) Peptide Pool
Supplier: STEMCELL Technologies
The CMV (pp65) peptide pool is a lyophilised mixture of 138 peptides from the 65 kDa phosphoprotein (pp65) of human cytomegalovirus (CMV; strain AD169). pp65 has been shown to counteract the induction of interferon response by preventing the activation of interferon response factor 3 (IRF-3). pp65 is also important in inducing transcription of viral immediate-early promoter. The pool consists of 15-mer peptides with 11-amino-acid overlaps that cover amino acids 1 to 561 on pp65.
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EBV (EBNA-1) Peptide Pool
Supplier: STEMCELL Technologies
The EBV (EBNA-1) Peptide pool is a lyophilised mixture of 158 peptides from Epstein-Barr nuclear antigen 1 (EBNA-1) of Epstein-Barr virus (EBV; strain B95-8). EBNA-1 plays a critical role in the stable latent infection by EBV and may contribute to the survival of EBV-infected cells through its interaction with ubiquitin carboxyl-terminal hydrolase 7 (USP7). The pool consists of 15-mer peptides with 11-amino-acid overlaps that cover amino acids 1 to 641 on EBNA-1.
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Candida (MP65) Peptide Pool
Supplier: STEMCELL Technologies
Stimulating T cells with Candida (MP65) peptide pool releases downstream cytokines and upregulates activation markers, enabling antigen-specific T cells to be detected or isolated for analysis. Candida peptide pool is a lyophilised mixture of 92 peptides from the mannoprotein MP65 of Candida albicans (yeast), and consists of 15-mer peptides with 11-amino-acid overlaps that cover amino acids 1 to 379 on MP65. MP65 contributes to cell wall integrity and epithelia adherence (Sandini et al.), and is a potent T cell immunogen (Gomez et al.). Viral peptide pools are useful for a broad range of applications, including vaccine development, immunological research, and diagnostic assay development.
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Human Recombinant EPO (CHO-expressed)
Supplier: STEMCELL Technologies
The principal physiological regulator of erythropoiesis, Erythropoietin (EPO) is a glycoprotein growth factor that is produced primarily in the kidney in response to hypoxia or anemia. EPO promotes erythropoiesis by binding to a homodimeric cell surface receptor that activates JAK2/STAT5, PI3K/AKT, and MAPK pathways, and stimulates the proliferation and differentiation of erythroid progenitor cells (Jelkmann. Transfus Med Hemother, 2013; Kuhrt and Wojchowski. Blood, 2015).
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Human Recombinant Noggin (CHO-expressed)
Supplier: STEMCELL Technologies
Noggin binds to and antagonizes bone morphogenetic protein (BMP) ligands of the transforming growth factor beta (TGF-β) family. Noggin supports maintenance of undifferentiated human embryonic stem cells in vitro, and can be used to prevent spontaneous differentiation in the short term (Chaturvedi et al.). Noggin is essential for development of structures derived from ectoderm embryonic somite, skeletal patterning, and neurogenesis in vivo. It also influences chondrogenesis, osteogenesis, and joint formation (Krause et al.), and promotes dopaminergic differentiation of embryonic stem cells and subsequent survival of dopamine neurons (Chiba et al.).
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Human Recombinant EGF
Supplier: STEMCELL Technologies
Epidermal growth factor (EGF) is characterized by high affinity binding to various EGF receptors (EGFRs) and the production of mitogenic responses (Carpenter and Cohen). EGF promotes EGFR dimerization, resulting in activation of downstream pathways including PI3K, ERK1/2, JAK/STAT, β-catenin, and calcium signaling. EGF is secreted by the gut-associated salivary and Brunner’s glands, is found in a variety of body fluids, and stimulates cell proliferation and differentiation in rodent and neonatal human intestine (Wright et al.). Central nervous system stem cells also proliferate in response to the EGF stimulus (Reynolds and Weiss).
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SARS-CoV-2 Recombinant Spike Protein, aa16-685 (HEK293-expressed), FLAG and His tags
Supplier: STEMCELL Technologies
SARS-CoV-2 Recombinant Spike Protein, aa16-685 is expressed in HEK293 cells and is one of four structural proteins encoded by the SARS-CoV-2 genome. The Spike Protein plays a key role in attachment to host cells, allowing invasion through clathrin-mediated endocytosis. The Spike Protein can be cleaved by host cell proteases after aa685 to yield the N-terminal S1 subunit and C-terminal S2 region. The S1 subunit is responsible for interacting with the host cell receptor (angiotensin-converting enzyme II) through a receptor-binding domain that is highly conserved with SARS-CoV. The S1 subunit has two conformations: a ‘down’ conformation in which the receptor is inaccessible, and an ‘up’ conformation in which the receptor is accessible. These conformational changes are key for monoclonal antibody drugs and vaccine development. SARS-CoV-2 Recombinant Spike Protein contains a polyhistidine tag at the amino terminus; it also contains a FLAG tag at the carboxy terminus.
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Human Recombinant VEGF-121
Supplier: STEMCELL Technologies
Vascular endothelial growth factor (VEGF-121) is a naturally-occurring VEGF-A splice variant involved in embryonic vasculogenesis and angiogenesis. VEGF binds to VEGFR-1 and VEGFR-2, and activates Raf/MEK/ERK and PI3K/AKT pathways. VEGF-121 is released as a freely diffusible protein by a variety of normal and transformed cells. It plays an important role in neurogenesis both in vitro and in vivo (Storkebaum et al.). It has neurotrophic effects on neurons of the central nervous system and promotes growth and survival of dopaminergic neurons and astrocytes. VEGF also promotes growth and survival of vascular endothelial cells, monocyte chemotaxis, and colony formation by granulocyte-macrophage progenitor cells (Ferrara et al.).
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Human Recombinant Amphiregulin
Supplier: STEMCELL Technologies
Amphiregulin is a member of the epidermal growth factor (EGF) family. It binds to several receptors including EGFR/ErbB1, HER2/ErbB2, HER3/ErbB3, and HER4/ErbB4, which activates Ras/Raf/MAPK and PI3K/AKT pathways. This results in cell proliferation, apoptosis resistance, and invasive behaviour (Normanno et al.). The expression of amphiregulin is induced by tissue injury and inflammation. Amphiregulin promotes mammary development, trophoblast growth, lung and kidney branching morphogenesis, and keratinocyte proliferation. It stimulates the growth of most cell types, including normal and transformed mammary epithelial cells, and malignant cells of the colon, prostate, cervix, and pancreas (Berasain and Avila).
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Human Recombinant IGF-I
Supplier: STEMCELL Technologies
Insulin-like growth factor 1 (IGF-I) is a polypeptide that belongs to the family of insulin-like growth factors that are similar in molecular structure to proinsulin. IGF-I binds to the IGF-I receptor and is a potent activator of the PI3K/AKT pathway and also activates ERK1/2 signaling. IGF-I is required for embryonic development, and it is produced mainly in the liver in response to a hepatocyte growth hormone. In the absence of insulin, IGF-I is necessary for the maintenance of human pluripotent stem cells (Wang et al.). Together with IL-3, IGF-I stimulates differentiation and proliferation of myeloid cells and has been shown to regulate lymphopoiesis by stimulating proliferation and differentiation of T and B cells in lymphoid organs (Heemskerk et al.).