You searched for: Proteins and Peptides

Supplier: Abcam

Recombinant human coronavirus SARS-CoV-2 Spike Glycoprotein S1 (mut W152C + L452R + D614G) (Active) is a SARS-CoV-2 full length protein, in the 1 to 685 aa range, expressed in HEK 293, with >90% purity, <1 EU/µg endotoxin level and suitable for SDS-PAGE, FuncS.

Supplier: SELENOZYME

The human GPX2 selenoprotein is encoded by the GPX2 gene and has potent hydrogen peroxide reducing activity using glutathione.
We provide the human GPX2 enzyme with approx. 20% Sec contents, mixed with inactive forms containing Sec-to-Lys and Sec-to-Gln substitutions, at more than 95% purity in aliquots at amounts from 0,5 to 5 units.

Supplier: SELENOZYME

The human GPX1 selenoprotein is encoded by the GPX1 gene and has potent hydrogen peroxide reducing activity using glutathione.
We provide the human GPX1 enzyme with approx. 20% Sec contents, mixed with inactive forms containing Sec-to-Lys and Sec-to-Gln substitutions, at more than 95% purity in aliquots at amounts from 0,5 to 5 units.

Supplier: Abcam

Recombinant mouse Alpha-synuclein protein aggregate Type 1 (Active) is a Mouse Full Length protein, in the 1 to 140 aa range with >95% purity, <5 EU/ml endotoxin level and suitable for SDS-PAGE, Functional studies, IHC, EM and ICC. The predicted molecular weight of ab246002 protein is 14,5 kDa. Suitable for Thioflavin T Fluorescence assay. Save time and ensure accurate results. Use our mouse Alpha-synuclein(SNCA) protein aggregate Type 1 protein as a control. Optimal protein bioactivity and stability.

Supplier: Abcam

Recombinant human CXCL10/IP10 protein (Active) is a Human Full Length protein, in the 22 to 98 aa range with ≥95% purity, ≤0,005 EU/µg endotoxin level and suitable for SDS-PAGE, Functional studies, mass spectrometry and HPLC. The predicted molecular weight of ab280332 protein is 8,7 kDa. Save time and ensure accurate results - use CXCL10/IP10 protein as a control - Optimal protein bioactivity, stability and reproducibility - Available in different sizes to fit the experimental needs.

Supplier: Enzo Life Sciences

Fluorogenic substrate for furin/SPC1/PACE/PCSK3 and other subtilisin/kexin-like proprotein convertases such as Kex2, SPC2/PC2/PCSK2, SPC3/PCSK1, PACE4/SPC4/PCSK6, SPC5/PC4/PCSK4, SPC6/PC5/PC6/PCSK5, and SPC7/LPC/PC7/PC8/PCSK7. Can be used on live cells. Ex: 340-360 nm, Em: 440-460 nm.

Supplier: Enzo Life Sciences

Fluorogenic substrate for TACE (ADAM17) (between Ala-Val), as well as MMP-3, MMP-7, MMP-12, and MMP-17, but not for ADAM19, MMP-13, nor MMP-14. Similar substrates are also cleaved by ADAM10, ADAM8 and ADAM9, and MMP-1, -2, and -9. This quenched substrate is useful for TACE inhibitor screening and kinetic analysis. Ex: 328 nm, Em: 393 nm, although the following Ex/Em have been used: 320-340/400-420. Also available: OMNIMMP® Fluorogenic Control peptide (BML-P127).

Supplier: Abcam

Recombinant Human Prostate Specific Antigen protein is a Human Full Length protein in the 25 to 261 aa range with ≥95% purity, ≤0,005 EU/µg endotoxin level and suitable for SDS-PAGE, mass spectrometry and HPLC. The predicted molecular weight of ab283430 protein is 26,15 kDa. Save time and ensure accurate results - use our Human Prostate Specific Antigen (PSA) protein as a control - Available in different sizes to fit your experimental needs.

Supplier: Abcam

AGE-BSA is modified bovine serum albumin (BSA) to create Advanced glycation end products (AGE)-BSA with >98% purity and suitable for SDS-PAGE. The predicted molecular weight of ab51995 protein is 66,5 kD. Save time and ensure accurate and specific results by using AGE- BSA protein as a control - Fluorescence of AGE-BSA: excitation/emission =370/440 nm - Cited in over 20 publications.

Supplier: Abcam

Recombinant human Hsp90 beta protein (Active) is a Human Full Length protein, in the 1 to 724 aa range, expressed in Baculovirus infected BTI-TN-5B1-4, with >90% purity and suitable for western blot, SDS-PAGE, ELISA, Functional studies and more.The predicted molecular weight of ab80033 protein is 90 kDa. Save time and ensure accurate results - use our Hsp90 beta protein as a control - Optimal protein bioactivity, stability and reproducibility - Available in different sizes to fit your experimental needs.

Supplier: Shenandoah Biotechnology

Acidic fibroblast growth factor (FGF-acidic), also known as FGF-1, is a potent inducer of DNA synthesis, cell proliferation, and has chemotactic activities. FGF-acidic regulates cardiogenesis through protein kinase C signaling. FGF-acidic also functions as an insulin sensitizer and mediates adipose tissue remodeling. High serum levels of FGF-acidic are associated with type 2 diabetes mellitus (T2DM), suggesting a pathogenic role of FGF-acidic during T2DM.

Supplier: Abcam

Recombinant Rabies Virus Glycoprotein (His tag) is a Rabies virus (strain ERA) Fragment protein, in the 20 to 459 aa range, expressed in Escherichia coli, with >90% purity and suitable for SDS-PAGE. The predicted molecular weight of protein is 65,6 kDa. - Save time and ensure accurate results - use recombinant Rabies Virus Glycoprotein (RABV G) as a control - Contains N-terminal 6x His-SUMO-tag.

Supplier: Abcam

Recombinant human TGF beta 1 protein (Active) is a human Full Length TGF-beta 1 protein, in the 279 to 390 aa range with >98% purity, <1 EU/µg endotoxin level and suitable for Cell Culture, Functional studies, western blot, HPLC and SDS-PAGE. The predicted molecular weight of ab50036 recombinant protein is 25 kDa. Save time and ensure accurate results.using our recombinant TGF-beta 1 cytokine protein.Optimal protein bioactivity, stability and reproducibility.Available in different sizes to fit your experimental needs.Cited in over 60 publications.

Supplier: Abcam

Streptavidin (HRP) is a Full Length native Streptavidin protein expressed in Streptomyces avidiniiand conjuated with Horseradish peroxidase (HRP). ab7403 has >95% purity and suitable for western blot, ELISA, IHC, ICC, Dot blot and more. - Used to detect biotin-conjugated primary antibodies - Has less non-specific binding and less background signal compared to avidin - Cited in over 170 publications.

Supplier: ProSci Inc.

DNA Fragmentation Factor Subunit Alpha (DFFA). DFFA exists as a heterodimer (DFF) with DFFB. DFF is activated once DFFA is cleaved by Caspase-3. The cleaved fragments of DFFA detach from DFFB (the active component of DFF), which in turn triggers DNA fragmentation as well as chromatin condensation during apoptosis. A reduced level of DFFA detected in ovarian endometriosis may be a part of an apoptosis-resistant mechanism enhancing the disease progression.

Supplier: Shenandoah Biotechnology

Cytokines for cell culture of human DIPG and other glioma cells. A glioma is a generic term used to describe tumors that arise from the glia tissue of the brain that supports and surrounds neurons. Diffuse Intrinsic Pontine Glioma (DIPG) is a pediatric brain tumor that originates in the brainstem. Cells isolated from these childhood tumors are successfully cultured ex vivo with EGF, FGF-basic (or FGF-2), and PDGFs (AA and BB).

Supplier: ProSci Inc.

Angiopoietin-related protein 4（ANGPTL4）is a secreted protein and contains 1 fibrinogen C-terminal domain. The protein may act as a regulator of angiogenesis and modulate tumorigenesis. It inhibits proliferation, migration, and tubule formation of endothelial cells and reduces vascular leakage. ANGPTL4 may exert a protective function on endothelial cells through an endocrine action. It is directly involved in regulating glucose homeostasis, lipid metabolism, and insulin sensitivity (By similarity). In response to hypoxia, the unprocessed form of the protein accumulates in the subendothelial extracellular matrix (ECM). The matrix-associated and immobilized unprocessed form limits the formation of actin stress fibers and focal contacts in the adhering endothelial cells and inhibits their adhesion. It also decreases motility of endothelial cells and inhibits the sprouting and tube formation.

Supplier: ProSci Inc.

CTLA-4 (Cytotoxic T-Lymphocyte Antigen 4) is also known as CD152 (Cluster of differentiation 152), is a protein receptor that downregulates the immune system. CTLA4 is a member of the immunoglobulin superfamily, which is expressed on the surface of Helper T cells and transmits an inhibitory signal to T cells. The protein contains an extracellular V domain, a transmembrane domain, and a cytoplasmic tail. Alternate splice variants, encoding different isoforms. CTLA4 is similar to the T-cell co-stimulatory protein, CD28, and both molecules bind to CD80 and CD86, also called B7-1 and B7-2 respectively, on antigen-presenting cells. CTLA4 transmits an inhibitory signal to T cells, whereas CD28 transmits a stimulatory signal. Intracellular CTLA4 is also found in regulatory T cells and may be important to their function. Fusion proteins of CTLA4 and antibodies (CTLA4-Ig) have been used in clinical trials for rheumatoid arthritis.

Supplier: Shenandoah Biotechnology

Placenta growth factor (PlGF) is a member of the vascular endothelial growth factor (VEGF) family and promotes endothelial cell growth and angiogenesis. PlGF is secreted as a homodimer and may also form a heterodimer with VEGF. PlGF is detected in the placenta, heart, lungs, thyroid, and adipose tissues. Circulating PlGF levels are correlated with colorectal and renal cancers, as well as atherosclerosis and ischemic heart disease. There are four alternatively spliced PlGF isoforms (PlGF-1, PlGF-2, PlGF-3, and PlGF-4), each with unique secretion patterns and heparin-binding affinities. PlGF-3 lacks a heparin-binding domain and signals through the VEGFR-1 receptor.

Supplier: Shenandoah Biotechnology

Placenta growth factor (PlGF) is a member of the vascular endothelial growth factor (VEGF) family and promotes endothelial cell growth and angiogenesis. PlGF is secreted as a homodimer and may also form a heterodimer with VEGF. PlGF is detected in the placenta, heart, lungs, thyroid, and adipose tissues. Circulating PlGF levels are correlated with colorectal and renal cancers, as well as atherosclerosis and ischemic heart disease. There are four alternatively spliced PlGF isoforms (PlGF-1, PlGF-2, PlGF-3, and PlGF-4), each with unique secretion patterns and heparin-binding affinities. PlGF-3 lacks a heparin-binding domain and signals through the VEGFR-1 receptor.

Supplier: ProSci Inc.

Tyrosine-protein phosphatase non-receptor type substrate 1 (SHPS1) is also known as CD172 antigen-like family member A (CD172a), Macrophage fusion receptor, MyD-1 antigen, Signal-regulatory protein alpha (SIRPA or SIRP alpha) or p84, is a member of the SIRP family, and also belongs to the immunoglobulin superfamily. SIRP alpha is Ubiquitous and highly expressed in brain. SIRPA / CD172a is immunoglobulin-like cell surface receptor for CD47 and acts as docking protein and induces translocation of PTPN6, PTPN11 and other binding partners from the cytosol to the plasma membrane. SIRPA / SHPS-1 supports adhesion of cerebellar neurons, neurite outgrowth and glial cell attachment and may play a key role in intracellular signaling during synaptogenesis and in synaptic function By similarity. SIRPA / MyD1 involved in the negative regulation of receptor tyrosine kinase-coupled cellular responses induced by cell adhesion, growth factors or insulin and mediates negative regulation of phagocytosis, mast cell activation and dendritic cell activation. CD47 binding prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells.

Supplier: Shenandoah Biotechnology

Cytokines for expansion and cell culture of human hematopoietic stem cells to progenitor cells. Hematopoietic stem cells are self renewing pluripotent cells often characterized by the expression of CD34. Studies have shown that decreased expression of CD34 tends to correlate with the decreased self renewal properties and pluripotent potential. Culturing CD34+ cells in a cytokine mixture of SCF, FLT-3 Ligand, IL-6 and IL-3 for short time periods allows rapid expansion of immature and more mature hematopoietic progenitor cells in cord blood or bone marrow preparations. If the goal is to only expand the most immature progenitor and stem cells, it is recommended that a combination of TPO, SCF and FLT-3 Ligand are used (Catalog: PB-500-03). Either cytokine combination can also be supplemented with other cytokines to promote specific lineages.

Supplier: ProSci Inc.

BH3-Interacting Domain Death Agonist (BID) is a member of the Bcl-2 protein family which regulates outer mitochondrial membrane permeability. BID is a pro-apoptotic member that causes cytochrome c to be released from the mitochondria intermembrane space into the cytosol. Interaction of Bid with Bak causes altered mitochondrial membrane permeability. BID contains only the BH3 domain, which is required for its interaction with the Bcl-2 family proteins and for its pro-death activity. BID is susceptible to proteolytic cleavage by caspases, calpains, Granzyme B and cathepsins. It is an integrating key regulator of the intrinsic death pathway that amplifies caspase-dependent and caspase-independent execution of neuronal apoptosis. Therefore pharmacological inhibition of BID provides a promising therapeutic strategy in neurological diseases where programmed cell death is prominent, and also offer a new strategy for the treatment of acute renal failure associated with ischemia-reperfusion. BID receives direct inputs from a key regulator of the cell cycle arrest/DNA repair machinery (ATM), and therefore is an excellent candidate to coordinate genotoxic stress responses and apoptotic cell death. BID is a novel pro-apoptosis Bcl-2 family protein that is activated by caspase 8 in response to Fas/TNF-R1 death receptor signals. Deletion of BID inhibits carcinogenesis in the liver, although this genetic alteration promotes tumorigenesis in the myeloid cells. This is likely related to the function of BID to promote cell cycle progression into S phase. BID could be also involved in the maintenance of genomic stability by engaging at mitosis checkpoint.

Supplier: Enzo Life Sciences

AMPK substrate

Supplier: Apollo Scientific

Recombinant Protein G

Supplier: Enzo Life Sciences

Mast cell degranulating peptide.

Supplier: Enzo Life Sciences

Mast cell degranulating peptide.

Supplier: Abcam

Protein A (Gold)

Supplier: Enzo Life Sciences

Insulin receptor substrate

Supplier: Apollo Scientific

Avidin