Genomics

Genomics, the study of genome structure, function, evolution, mapping and editing, lets scientists learn more about human molecular biology. Genomics research creates enormous potential to reshape drug development and paves the way to personalized medicine. Avantor^® offers a wide range of genomics tools and solutions, whether you are advancing gene therapies and personalized medicine or working on next-generation sequencing and genome editing.

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We can help you stock your genomics laboratory.

Nucleic acid purification and measurement

Purified DNA samples can be generated by lysing (bursting or cutting) a cell or cell structure, removing contaminants from the lysate and isolating the DNA. Purifying DNA samples extends their shelf life and reduces the probability of error in ensuing research results.

Avantor^® can help you source high-quality nucleic acid purification systems that are simple to operate and generate rapid results. Here are some choices below.

Automated purification systems

Get the automated nucleic acid purification systems you need for your lab.

Automated nucleic acid sample QC

Automated electrophoresis systems for nucleic acid sample QC.

Microplate readers

Robust, compact and high-value microplate readers for your biological assays.

Nucleic acid purification kits and reagents

Reagents and kits to isolate DNA and/or RNA from different samples for downstream applications.

Sample disruption and homogenization

Our manual and automated benchtop homogenizers have user-friendly control systems for straightforward processing.

Surface decontamination

A selection of cleaning agents to remove, inactivate or destroy contaminants.

Amplification

Amplification is a technique used to increase the quantity of a specific DNA sequence, making it easier to study and analyze when only a small amount of original DNA is available. DNA amplification is used in clinical diagnostics, genetics research and forensic science. Polymerase chain reaction (PCR), an amplification method used to replicate DNA sequences, is widely used because it can generate millions of copies in a short period of time.

Amplifying DNA allows researchers to observe gene variations, mutations and expression patterns to gain insight into disease mechanisms, hereditary traits and potential therapeutic approaches. Avantor^® offers a wide range of products that help you perform successful DNA amplification for your lab’s research.

Centrifuge for PCR plates

See our broad range of centrifuges for PCR applications and more.

End-point PCR enzymes and kits

We offer a variety of end-point PCR reagents and kits.

Filter tips

Filters block aerosol contaminants to protect both the equipment and samples.

Microplate sealing films and foils

We have a broad range of microplate sealing films and foils to reduce evaporation during reactions.

Nucleotides

Shop our wide selection of high-purity nucleotides.

PCR and qPCR plates

We offer a wide variety of PCR plates.

PCR and qPCR thermal cyclers

See our thermal cyclers for PCR and qPCR applications.

PCR tubes

Discover our large selection of high-quality PCR tubes.

PCR workstations

PCR workstation enclosures provide the contamination-free environment required for detecting the most sensitive DNA protocols.

Primers and probes

Selected primers and probes for cDNA synthesis, sequencing and hybridization applications.

qPCR/RT-qPCR enzymes and kits

Get the reagents you need for qPCR at Avantor^®.

Racks for PCR tubes

Racks to store PCR tubes and prepare your PCR samples.

RT-PCR and cDNA synthesis reagents

Reagents and kits for reverse transcription PCR and cDNA synthesis.

Sequencing in genomic life sciences

Sequencing is the “gold standard” method for identifying unspecified genomic DNA variants.

Two common DNA sequencing techniques are shotgun and high-throughput sequencing. Shotgun sequencing (also known as Sanger sequencing) is the more traditional approach and is designed for sequencing chromosomes or long DNA strands of more than 1000 base pairs. This process breaks a DNA strand into short fragments of 100 to 1000 base pairs and then rapidly reassembles them using a computer program to reconstruct the original strand sequence.

High-throughput sequencing is also known as next-generation sequencing (NGS). It allows for the simultaneous sequencing of both DNA and RNA, and its ability to rapidly and affordably generate large amounts of genetic data has revolutionized genomics research.

Avantor^® offers sequencing supplies from industry leaders. Whether your lab uses shotgun or high-throughput sequencing, our tools and resources can help.

NGS systems

See our range of DNA/RNA sequencing devices.

Nanopore sequencing flow cells

Flow cells needed for nanopore sequencing devices.

NGS library prep kits and reagents

Kits and reagents for preparing DNA/RNA libraries for NGS.

Electrophoresis and detection

Electrophoresis is a technique for separating DNA, RNA or protein molecules. It moves molecules through a gel or other via an electric current, separating them based on size. Avantor^® offers a large selection of electrophoresis tools and solutions from trusted brands to ensure that your results are reliable.

Agarose

See our agarose selection for nucleic acid gel electrophoresis.

Blotting apparatus

Choose from various blotting apparatus for Southern, western, and northern blotting procedures.

Blotting papers

Shop our selection of blotting papers for blotting processes.

Electrophoresis buffers

These electrophoresis buffers offer the ultimate in convenience.

Ethidium bromide

Find the ethidium bromide format you need.

Gel stains

We offer a variety of electrophoresis stains for your needs.

Horizontal electrophoresis tanks

Shop our wide selection of horizontal gel electrophoresis systems.

Hybridization equipment

Choose from our selection of hybridization ovens with rapid heat-up capabilities and precise temperature control.

Markers and ladders

Molecular weight markers are ideal for verifying PCR products and for size analysis of digested DNA.

Photo documentation systems

Get highly reproducible quantitative data.

Power supplies

Select the power supply that you need for your electrophoresis and blotting applications.

Transilluminators

We offer a wide variety of transilluminators to meet your needs.

UV crosslinkers

Find the most popular UV crosslinkers.

DNA/RNA modification, cloning and delivery

Genetic modification and cloning are different ways of manipulating an organism’s DNA. From an original DNA sample, cloning creates an exact copy, while genetic modification alters the existing DNA to create a new, modified version.

Find everything your lab needs for DNA/RNA modification, cloning and delivery. From DNases to transfection reagents, Avantor® offers all the essential tools.

Cloning kits and vectors

See our wide selection of kits for cloning and ligation.

Competent cells

We offer a variety of competent cells for cloning and protein work.

DNases

See our extensive range of enzymes capable of degrading DNA for multiple applications.

Electroporators

See our selection of best-in-class electroporators.

Electroporation cuvettes

A comprehensive line of electroporation cuvettes to meet your needs.

Electroporation buffers

Increase transformation and transposition efficiency with high-quality electroporation buffers from Avantor^®.

Ligases

DNA and RNA ligases for cloning, mutagenesis and NGS.

Restriction enzymes

Get the restriction enzymes you need at Avantor^®.

RNases

See our offering of RNase enzymes for cleaving RNA molecules.

Transfection reagents

See our wide selection of transfection reagents.

Genomic Life Sciences: An Overview

Human genetics research has many applications in medicine, biotechnology, anthropology and other social sciences. Genomics combines DNA sequencing and bioinformatics methods to sequence, assemble and analyze the structure and function of genetic material.

Mapping a human genome — the complete set of genes or genetic material within a cell or organism — is time consuming and can produce a terabyte (TB) of unorganized data.

As technology advances and data becomes easier to store and comprehend, an increasing number of health care providers will use genomics to diagnose and treat patients, advancing the field of personalized medicine.

Genomics in the lab

Genomics research uses modern technologies to analyze the structure and function of an organism's complete DNA sequence.

This requires a variety of tools and techniques:

Electrophoresis and purification systems to isolate DNA templates
Polymerase chain reaction (PCR) and sequencing technologies for DNA sequencing and mapping
Microarray analysis and genotyping to determine to compare and contrast sequences
Mass spectrometry for oligonucleotide (short-chain DNA or RNA molecules) analysis
Next-generation sequencers are for analyzing whole genomes

Most scientific laboratories use some genomics tools for their research, clinical or forensic applications.