2466 Results for: "STEMCELL Technologies"

Supplier: STEMCELL Technologies

Immunomagnetic isolation of untouched human eosinophils.

Supplier: STEMCELL Technologies

The SARS-CoV-2 (Nucleocapsid protein) Peptide pool is a lyophilised mixture of 102 peptides from the nucleocapsid protein of SARS-CoV-2. Nucleocapsid protein is one of four structural proteins that interacts with RNA to form the nucleocapsid. It also interacts with membrane protein (protein M) in the packaging of positive-strand viral genome RNA during virion assembly. The pool consists of 15-mer peptides with 11-amino-acid overlaps that cover amino acids 1 to 419 on SARS-CoV-2 nucleocapsid protein.

Supplier: STEMCELL Technologies

Mouse monoclonal IgG2a, antibody against human CD3, unconjugated.

Supplier: STEMCELL Technologies

Enhanced green fluorescent protein (eGFP)-tagged Cas9 nuclease for the generation of double-strand breaks in CRISPR-Cas9 genome editing.

Supplier: STEMCELL Technologies

Fluorescent lipophilic dye used to quantify mitochondrial membrane potential and assess cell viability.

Supplier: STEMCELL Technologies

Cell culture medium for passaging and long-term expansion of human alveolar epithelial type II (ATII) cells as organoids.

Supplier: STEMCELL Technologies

Sensitive fluorescent dye that detects superoxide production in mitochondria - 500 tests.

Supplier: STEMCELL Technologies

Interleukin 1 receptor antagonist (IL-1RA) is a member of the IL-1 family that binds to IL-1 receptors but does not induce any intracellular signaling (Arend et al.). IL-1RA is a natural regulator of IL-1’s biological activity. It binds to the IL-1 receptors with similar affinity as IL-1, thereby inhibiting the proinflammatory activities of IL-1ɑ and IL-1ꞵ (Kinne et al.). In particular, mesenchymal stem cells have been shown to enhance tissue repair in an IL-1RA-dependent manner through the suppression of IL-1ꞵ production in dermal macrophages and enhanced expansion of immunosuppressive regulatory T cells in the skin (Harrell et al.). IL-1RA has also been shown to help in the treatment of rheumatoid arthritis (Cutolo), sepsis, asthma (Mao et al.), and inflammatory bowel diseases (Dosh et al.). This product is animal component-free.

Supplier: STEMCELL Technologies

Culture medium kit for growth, and establishment of human pancreatic organoids.

Supplier: STEMCELL Technologies

Immunomagnetic isolation of basophils directly from whole blood

Supplier: STEMCELL Technologies

Fast and easy isolation of human extracellular vesicles using immunomagnetic positive selection.

Supplier: STEMCELL Technologies

Immunomagnetic positive selection of human CD33+ cells (e.g. myeloid cells).

Supplier: STEMCELL Technologies

Immunomagnetic positive selection of F4/80+ cells from mouse splenocytes, lung tissue, and peritoneal lavage.

Supplier: STEMCELL Technologies

Culture medium for long-term expansion and maintenance of human liver organoids.

Supplier: STEMCELL Technologies

Mouse monoclonal IgG1 antibody against human, mouse, rat acetylated alpha-tubulin (acetyl K40).

Supplier: STEMCELL Technologies

HBV (HLA Class I Control) Peptide pool is a lyophilised mixture of 9 peptides from the hepatitis B virus (HBV). The pool consists of defined HLA class I-restricted T cell epitopes, and can be used as an antigen-specific positive control to stimulate T cells.

Supplier: STEMCELL Technologies

Mouse monoclonal IgG1 antibody against human angiotensin-converting enzyme 2 (ACE2).

Supplier: STEMCELL Technologies

Fluorescent dyes used to label and track lysosomes in live cells - 500 tests.

Supplier: STEMCELL Technologies

Mouse monoclonal IgG1, antibody against human, chimpanzee CD4, PE-conjugated.

Supplier: STEMCELL Technologies

Hamster (Armenian) monoclonal IgG, antibody against mouse, CD152 (CTLA-4), PE-conjugated.

Supplier: STEMCELL Technologies

Mouse monoclonal IgG2b, antibody against human, chimpanzee, CD45RA, PE-conjugated.

Supplier: STEMCELL Technologies

SARS-CoV-2 Recombinant Spike Protein, aa319-541 is expressed in Pichia pastoris and is one of four structural proteins encoded by the SARS-CoV-2 genome. The Spike Protein plays a key role in attachment to host cells allowing invasion through clathrin-mediated endocytosis. The spike protein can be cleaved by host cell proteases after aa685 to yield the N-terminal S1 subunit, and C-terminal S2 region. The S1 subunit is responsible for interacting with the host cell receptor (angiotensin-converting enzyme II) through a receptor-binding domain that is highly conserved with SARS-CoV. The S1 subunit has two conformations: a ‘down’ conformation in which the receptor is inaccessible, and an ‘up’ conformation in which the receptor is accessible. These conformational changes are key for monoclonal antibody drugs and vaccine development. At the amino terminus of the polypeptide chain, SARS-CoV-2 Recombinant spike protein contains a polyhistidine tag and a SUMOstar site.

Supplier: STEMCELL Technologies

Human Recombinant Angiotensin-Converting Enzyme 2 (ACE2) Protein, aa18-740, is expressed in HEK293 cells. ACE2 activity results in vasodilation by degrading vasoconstrictor angiotensin II to produce vasodilator angiotensin. Decreased expression of this enzyme is associated with cardiovascular disease and possibly also glomerular injury in diabetic nephropathy. ACE2 contains a peptidase domain at the N-terminus and a single transmembrane helix. ACE2 is also the primary human receptor for the surface spike glycoprotein of SARS-CoV-2 and SARS-CoV. This receptor is expressed in human lung and small intestine epithelia as well as the heart, kidney, and testes. The peptidase domain of ACE2 binds to the protein-binding domain of the S1 protein subunit of the spike protein; this binding results in a cleavage site becoming exposed. Cleavage, or ‘protein priming’, is done by TMPRSS2, a cellular serine protease, and by cathepsins. This cleavage activates the S2 subunit of the spike protein, allowing the fusion of the viral membrane to the host cell membrane. At the carboxy terminus, Human Recombinant ACE2 Protein contains a TEV site and a human IgG1 Fc tag.

Supplier: STEMCELL Technologies

FRET-based peptide substrate for detection of protease activity of coronaviruses - 100 tests.

Supplier: STEMCELL Technologies

Culture supplement for the differentiation of human naïve CD4+ T cells into Th2 cells.

Supplier: STEMCELL Technologies

Immunomagnetic isolation of untouched human T cells.

Supplier: STEMCELL Technologies

Ready-to-use marker dye for loading DNA samples into agarose gel wells and tracking migration during electrophoresis.

Supplier: STEMCELL Technologies

Rat monoclonal IgG2a antibody against human, mouse, cat CD45R (B220), Pacific Blue™-conjugated.

Supplier: STEMCELL Technologies

Mouse monoclonal IgM antibody against human, chimpanzee CD66b, Pacific Blue™-conjugated.

Supplier: STEMCELL Technologies

Rat monoclonal IgG2b antibody against human, mouse, rhesus CD11b, Pacific Blue™-conjugated.