Anti-CD41 Mouse Monoclonal Antibody [clone: HIP8] (FITC)

Supplier: STEMCELL Technologies

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Supplier: STEMCELL Technologies

About this item

Mouse monoclonal IgG1 antibody against human, rhesus, cynomolgus CD41, FITC-conjugated.

Megakaryocytes
Platelets

The HIP8 antibody reacts with the ~125 kDa GPIIbα subunit of human CD41, a heterodimeric integrin expressed primarily on platelets, megakaryocytes, monocytes, and acute megakaryoblastic leukemia cells. The GPIIbα subunit is linked to a smaller ~25 kDa subunit (GPIIbβ) by a single disulfide bond. Three isoforms of CD41 that are generated by alternative splicing have been identified, one of which is expressed only by cancerous cells. CD41 associates non-covalently with CD61 (integrin b3) in a calcium-dependent manner to form the CD41/CD61 (or GPIIb/IIIa) complex, which has been identified as a receptor for several ligands, including fibrinogen, fibronectin, vitronectin, and thrombin. Binding to the CD41/CD61 complex involves an RGD tripeptidyl sequence in the ligand, and both ligand occupancy and ligand-mediated receptor clustering are functionally important in the integrin-mediated response. The HIP8 antibody reportedly blocks platelet aggregation and inhibits the activation of platelets by several compounds.

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Type:
Antigen: CD41
Clonality: Monoclonal
Clone: HIP8
Conjugation: FITC
Epitope:
Host: Mouse
Isotype: IgG1 kappa
Reactivity: Baboon;Capuchin monkey;Chimpanzee;Cynomolgus monkey;Human;Pig;Rhesus monkey

Specifications

Catalog No:
STMC60114FI
STMC60114FI.1

Antigen name:
CD41
CD41

Clonality:
Monoclonal
Monoclonal

Conjugation:
FITC (Fluorescein Isothiocyanate)
FITC (Fluorescein Isothiocyanate)

Clone:
HIP8
HIP8

Reactivity:
Baboon, Capuchin monkey, Pig, Cynomolgus monkey, Rhesus monkey, Chimpanzee, Human
Baboon, Capuchin monkey, Pig, Cynomolgus monkey, Rhesus monkey, Chimpanzee, Human